Báo cáo khoa học: WFIKKN1 and WFIKKN2 bind growth factors TGFb1, BMP2 and BMP4 but do not inhibit their signalling activity docx
Báo cáo khoa học: WFIKKN1 and WFIKKN2 bind growth factors TGFb1, BMP2 and BMP4 but do not inhibit their signalling activity docx
... compilation ª 2010 FEBS WFIKKN1 and WFIKKN2 bind growth factors TGFb1, BMP2 and BMP4 but do not inhibit their signalling activity Gyo¨rgy Szla´ma, Katalin Konda´s, Ma´ria Trexler and La´szlo´PatthyInstitute ... 300 400 500 600 700 800Time (s)F BMP2 BMP4 BMP2 -WFIKKN1 BMP4 -WFIKKN1 BMP2 -WFIKKN2 BMP4 -WFIKKN2 Fig. 3. Effect of WFIKKN1 and WFIKKN2 on the binding of BMP2 and BMP4 to the ECD of BMPRIA monitored ... (s)RURURURURURURU RU RU RU WFIKKN1- BMP4 602203800 200 400 600 800BTime (s) WFIKKN2- BMP4 WFIKKN1- TGFβ 1WFIKKN2- TGF1 WFIKKN1- BMP2 WFIKKN2- BMP2 WFIKKN1- BMP3 WFIKKN2- BMP3 WFIKKN1- BMP8b WFIKKN2- BMP8bFig....
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Báo cáo khoa học: Nucleocytoplasmic shuttling of STAT transcription factors Thomas Meyer and Uwe Vinkemeier doc
... interactions [6], a DNA binding domain [7], alinker domain that participates in DNA binding [8], anSRC homology 2 (SH2) domain that mediates dimeriza-tion and receptor binding [9], and a carboxy-terminaltransactivation ... from the DNA binding domain of STAT1 harborsoverlapping e xport and import activities. Notably, the import activity is observed only in the native STAT dimer, whereas the exp ort activity is ... phosphorylation of the receptor. TheSTATs dock to these sites via their SH2 domains and become tyrosinephosphorylated conc omitan tly. The a ctivated STATs de tach and homo- or heterodim erize.Ó FEBS...
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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx
... b-strand 3Õ (i.e. theb-hairpin loop and part of the adjoining b-sheet) and Ôresidues in the loop connecting b-strand and a-helix and contiguous residues on the a-helix and the last part ofb-strand ... membrane binding and disruption. Note thatbasicity and hydrophobicity are not exclusive characteri-stics of this part of the molecule, but only loop 3-derivedpeptides have demonstrated activity. ... 7–16) and two antiparallel b-strands (residues20–25 and 33–39) [16]. The a-helix and the b1-strand areconnected by a distorted type II turn (loop 2), whereas theloop connecting both strands...
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Báo cáo khoa học: Lid L11 of the glutamine amidotransferase domain of CTP synthase mediates allosteric GTP activation of glutaminase activity docx
... the model of GTPbinding at the predicted site (Fig. 1A) at the interfacebetween the GATase domain and the synthase domain[13]. Amino acid residues in the synthase domain and residues of lid ... kinetics,the R359M, R359P and G360P enzymes were altered inboth GTP binding and activation. The R359M enzymedisplayed about fourfold and 10-fold decreases in kcat1 and kcat2, respectively, ... R359P and G360P were similar as kcat1 and kcat2were reduced about 10-fold and more than 25-fold,respectively, and KAfor GTP was increased by about10-fold. The determined kcat1 and kcat2for...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... subunitRII binding domain, the central domain (CD) and the microtubule-binding domain (Fig. 3A). To deter-mine the v-KIND-binding region in MAP2, we firstdivided MAP2 into five regions (Fig. 3A) and ... regulatory subunit RII binding domain (RII), the central domain (CD)1-3 and the microtubule-binding domain (MBD)] and corresponding GST fusion proteins were generated. (B), Pull-down assay (PD) of ... JNK1(such as downstream of v-KIND overexpression [12])enhances the activity of MAP2 to bind to microtubules and promote their assembly [18], and that the inhibitionof JNK1 (such as downstream...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... to caspase fragments and inhibit their peptide-specific activity, other proteolytic activity stilloccurs [15,51]. Moreover, cleavage is not necessary toactivate caspase-8 and probably its close ... apoptosis, and itsinhibitor ICAD. Nature 391, 43–50.18 Hanus J, Kalinowska-Herok M & Widlak P (2008)The major apoptotic endonuclease DFF40 ⁄ CAD is adeoxyribose-specific and double-strand-specific ... fromICAD in an active form [17]. CAD is a DNA-specific,double-strand-specific endonuclease, whose activity leads to the generation of double-stranded breaks ininternucleosomal chromatin regions [18]....
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... helix–span–helix DNA-binding and dimerization domain at their C-terminus, and a lessconserved proline-rich and glutamine-rich transactiva-tion domain at their N-terminus [8–10]. Most isoformsalso ... N-terminal trans-activation domain that is important for their role astranscriptional activators [9]. The AP-2 factors formhomodimers and heterodimers for their transcriptional activity. A multiple ... humans and mice. Orthologs ofsome AP-2s have also been found in frogs and fish, and homologs occur in invertebrates. All AP-2s have ahighly conserved basic helix–span–helix DNA-binding and dimerization...
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Tài liệu Báo cáo khoa học: RMI1 deficiency in mice protects from diet and genetic-induced obesity pptx
... disorders [6]. Withthis method, it is possible to mutate the mouse genomerandomly on a large scale, and then isolate and identify the mutated gene. Several other genes havebeen identified by ... between RMI1 and energy homeostasis as wellas the contribution of RMI1 to the regulation of E2Fexpression, which is a well-documented cell cycle-related molecule.ResultsIn vivo phenotype-driven ... were kept for 14 weeks, and monitored for body weight changes and food intake.Initially, the male RMI1+ ⁄ ) mice weighed less than their male RMI1+ ⁄ + littermates, and those fed a nor-mal...
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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... miR-23a promotes growth activity of MGC803 cells. MGC803 cells weretransfected with miR-23a ASO or pri-23avector, and cell growth activity wasdetected through the MTT (A) and colonyformation ... slows PC-3 and LNCaP cell growth, demonstrating its antiproliferative activity [20]. Another study has demonstrated theinduction of antiapoptotic regulators by IL6 ⁄ IL6R inboth naive and activated ... were undertakenwith the understanding and written consent of each subject.The study methodologies conformed to the standards set bythe Declaration of Helsinki, and were approved by the localethics...
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Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt
... low-affinityHSE and a binding site for the general stress responsetranscription factors Msn2 and Msn4 (Msn2 ⁄ 4).However, HSF and Msn2 ⁄ 4 are not preloaded on thispromoter. Heat-induced binding of ... protein exhibits a reduced ability to trimerize and is unable to bind to discontinuous gap- and step-typeHSEs, but binding to the continuous 3P-type HSE is not affected [21]. In contrast, an amino ... withthe notion that although DNA-binding transcription factors of the same family bind the same highest-affin-ity sites, they prefer different lower-affinity sites, and that low-affinity sites do contribute...
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