Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot
Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot
... envelope One of the goals of the present study was to deter-mine the cleavage sites of hatching enzyme on egg envelope proteins. The natural substrate of hatching enzyme is fertilized egg envelope ... discuss the mechanism of egg envelope digestion by hatching enzyme, mainly based on the structural characteristics of egg envelope protein. In medaka, HCE swells the hardened fertilized egg envelope ... forma-tion of e-(c-glutamyl) lysine cross-links between sub-unit proteins of the envelope, mainly between innerlayer subunit proteins [10]. At the time of hatching of the embryo, the inner layer...
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Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx
... accompa-nied by a reduction in the amount of cytosolic Sp1. In order to determine whether glutamine increases the binding of Sp1 to the SREBP-1a promoter regioncontaining the Sp1-binding elements, we performed ... containing amutated sequence of the SRE, pSQS containing the humanSQS promoter, pSQS SREKO containing two mutatedSREs, pLDLR containing the human LDL receptor pro-moter, and pMTP containing the ... (Fig. 3A), implying that the gene expression of SREBP-2 is induced by the acti-vation of the SREBP in response to the higher gluta-mine concentration. In contrast, the elevation of the SREBP-1a...
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Báo cáo khoa học: Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion pot
... with other macromolecules as part of the PCSK9-mediated degradation of the LDLR. A cluster of residues on the conserved protrusion is involved in the binding of PCSK9 to the EGF-A domain of the LDLR, ... detected in any urochordate, e.g. in the fairly well-studied Ciona intestinalis, or in any otherinvertebrates. The C-terminal domain of PCSK9, the CRD, was not found in any vertebrate protein apartfrom ... showing the signal sequence and N-terminus of the prodomain (A), two segments of the catalytic domain (B), and the fullCRD, the C-terminal domain (C). Conserved residues are indicated by numbering...
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx
... Todistinguish total binding from non-specific binding, cells wereincubated for 10 min in either PBSCM alone or PBSCMcontaining 200 lm cocaine for inhibition of DAT or 200 lmS-citalopram for inhibition ... Values are the mean of six replicates. The specific uptake was determined bysubtracting the uptake counts in the absence of inhibitorfrom the uptake counts in the presence of cocaine or S-cita-lopram, ... supplied with 100 mm glycine, andincubated for 20 min to quench further cross-linking. The quenching buffer was removed by washing twice in PBSCM,and the cells were then lysed in lysis buffer (PBSCM,...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... 2A). The zinc ions are requiredfor the structural integrity of the protein, as mutation of any of the cysteine residues involved in zinc coordina-tion results in protein unfolding [22]. The ... include the MLL1 CXXC domain [22], a portion of the MLL1TAD bound to the KIX domain of the cAMPresponse element-binding (CREB) binding protein(CBP) [23], a peptide from the Win motif of MLL1bound ... value as inhibitors of SET1 family complexes.Binding of the MLL1 Win motif to the central argi-nine-binding pocket of WDR5 raises questions about the proposed role of WDR5 in binding histone H3,...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... examining the role of GIF in AD, linked to its initial discovery as a factordeficient in the AD brain. There remains no clear con-sensus on the role of GIF in the pathogenesis of AD,and therefore ... in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularlywithin the injured or diseased brain. In the case of GIF, the protein has many neuroprotective ... whether GIFacts in a neuroinhibitory manner when administereddirectly into the brain following traumatic brain injury. In one such study, the injection of GIF into the site of a stab wound promoted...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... repre-sent the last subunits incorporated into the bc1com-plex. On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP(Fig. 4B). Interestingly, in the ... comparable amounts in both yeast strains. Therefore, the reason for the disap-pearance of the bc1dimer in the yeast strain in whichQcr10p is missing remains unknown.On the basis of all the above ... specificallyrequired for the insertion of ISP into an immature bc1complex and that the association of the Qcr9p subunitwith the bc1complex precedes the binding of ISP. In fact, the direct absence of ISP (DISP),...
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Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
... and GH13 enzymes is the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs andGH13 enzymes, and ... domain,including domain B and the C-terminal domain C forrBAT proteins (669 residues on average); (b) the cata-lytic TIM barrel domain, including domain B and the C-terminal domain C for GH13 enzymes ... Some of thesefeatures can be traced in the sequences of hcHAT1and hcHAT2 groups as well as of the ATG proteins(Fig. 2), indicating evolutionary relationships of allthese enzymes and proteins...
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Tài liệu Báo cáo khoa học: Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide doc
... fromC. intestinalis expressed in vitro and native enzyme expressed in vivo indicates the enzyme is AChETo determine the nature of the cholinesterase activity of the recombinant C. intestinalis enzyme ... with the PRAD domain of ColQ indicates that the WAT domain of the C. intestinalis AChE is capable of organizing the sub-units into a tetramer through interaction with the PRAD domain of ColQ. The ... AChETo determine further the nature of the cholinesteraseactivity of the recombinant enzyme, we determined halfmaximal inhibitory concentration (IC50) values of the enzymes for the inhibitors...
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... responsible for the calcium binding [8], we hypothesize that this bind-ing event takes place at the C2 domain.A second calcium-binding site of lower affinity at the C2 domain (corresponding to the dissociationconstant ... belongsto the C2 domain (141 amino acids) with its extendedloops, whereas the lid-like region at the top representsanother flexible part of the structure. Assuming that the core protein containing the ... biospecific interactions. We assumethat calcium ions are involved in enzyme activation byguiding the protein to the membrane, mediating sub-strate binding, or adjusting the charge distribution atthe...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015