Báo cáo khoa học: Active site residue involvement in monoami

Báo cáo khoa học: Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase doc

... (2011) 1232–1243 ª 2011 The Authors Journal compilation ª 2011 FEBS 1243 Active site residue involvement in monoamine or diamine oxidation catalysed by pea seedling amine oxidase Maria Luisa Di Paolo 1 , ... fac- tors underlying substrate selectivity still remain to be discovered. With this in view, we examined the kinetic behaviour of pea seedling amine...

Ngày tải lên : 06/03/2014, 00:21

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Tài liệu Báo cáo khóa học: Active-site residues and amino acid speciﬁcity of the bacterial 4¢-phosphopantothenoylcysteine synthetase CoaB pptx

... of substrates by forming energy-rich thioester bonds. Oxo- coenzyme A (which has an ethanolamine residue instead of a cysteamine residue) cannot fulﬁll this role and may inhibit cell growth. Therefore, ... converted to PPC (in presence of cysteine) or to PP (in the presence of cysteamine) or to 4¢-phosphopantothenoylcysteine methyl ester (in the Fig. 3. Residues that are crucial f...

Ngày tải lên : 19/02/2014, 12:20

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Báo cáo khoa học: Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase pot

... been suggested to be important for the ability of HSV-1 TK to bind and phosphorylate the acyclic guanosine analogues. The corresponding amino acid residue in Dm-dNK is an isoleucine (I29). To investigate ... deoxyribonucleoside kinase; dCK, deoxycytidine kinase; dGK, deoxyguanosine kinase; TK2, thymidine kinase 2; HSV-1 TK, herpes simplex virus type-1 thymidine kinase; dAdo, deoxyadenos...

Ngày tải lên : 08/03/2014, 02:21

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Báo cáo khoa học: Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase docx

... maintains almost iden- tical CoA binding site and the catalytic triad of Cys164, His303, and Asn336 (numbering in M. sativa CHS) (Fig. 2). Furthermore, most of the active site residues including ... located in proximity of the catalytic Cys164 at the ‘ceiling’ of the active site cavity guides the growing polyketide chain to extend into the buried pocket. I. Abe et al. Active...

Ngày tải lên : 16/03/2014, 14:20

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Báo cáo khóa học: Active site residues and mechanism of UDP-glucose dehydrogenase ppt

... covalently bound to an active site lysine residue via an imine linkage [18]. This suggestion was supported by experiments on the bovine liver enzyme in which the active site cysteine thiol had been ... observed in approximately equal amounts, conﬁrming that the reaction was accompanied by incor- poration of a single solvent-derived oxygen atom. In order to determine the po...

Ngày tải lên : 23/03/2014, 12:20

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Báo cáo khoa học: Active-site-speciﬁc chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx

... catalytically fully or partially active. Active- site direc- ted competitive inhibitors are often effective active- site- specific chaperones when they are used at subinhibitory concentrations. Active- site- specific chaperones ... first domain contains the active- site formed by the C-terminal ends of the b strands at the center of a barrel. Thirteen amino acid residues were pred...

Ngày tải lên : 30/03/2014, 03:20

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Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf

... regions lining the substrate-binding site allow the enzyme to conform to substrates of varying structure. This study describes mutant forms of thimet oligopeptidase in which Gly or Tyr residues in ... around the active site residues of domain I and the loop and Tyr residues in domai- n II supports our initial conformation for the model. Furthermore, the experimental effects obse...

Ngày tải lên : 23/03/2014, 06:20

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Tài liệu Báo cáo khoa học: The bacterium, nontypeable Haemophilus inﬂuenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression ppt

... receptor and downstream adaptors are involved in TLR7 induction by NTHi. Because TLR2 is important for mediating NTHi-induced gene transcription, we ﬁrst investigated the role of TLR2 in NTHi-induced ... bacterial prod- ucts including peptidoglycan, lipoprotein and lipoara- binomannan [1–5]. The importance of TLR2 in host Keywords cylindromatosis; mixed infection; nontypeable Haemophi...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: "Identifying Agreement and Disagreement in Conversational Speech: Use of Bayesian Networks to Model Pragmatic Dependencies" docx

... ﬁrst performed several empirical analyses in order to determine to what extent contextual informa- tion helps in discriminating between agreement and disagreement. By integrating the interpretation ... baseline algorithm. 3.2 Maximum Entropy Ranking We view the problem as an instance of statistical ranking, a general machine learning paradigm used for example in statistical pars...

Ngày tải lên : 20/02/2014, 16:20

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Báo cáo khóa học: Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide doc

... binding constants to the proteins. According to Schemes 1 and 2, the nitrating species produced by the enzyme is either NO 2  ,formedby compound I or II and nitrite (pathway A), or E nitr formed by ... Spectroscopic and binding studies on the interaction of inorganic anions with lactoperoxidase. J. Inorg. Biochem. 68, 17–26. 35. Gebicka, L. (1999) Kinetic studies on the oxidation o...

Ngày tải lên : 16/03/2014, 16:20

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