Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... upregulates the expres-sion of the mitochondrial protein uncoupling protein 2 (UCP2), and pre-treatment with vitamin E attenuates upregulation of UCP2. These findingssuggest that the MDP-induced reactive ... (20 11) 3054–3064 ª 20 11 The Authors Journal compilation ª 20 11 FEBS Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and ... correlating the uncoupling effectinduced by these molecules with the level and function of UCP2 and free radical production in macrophages. We find that MDP induces reactive oxygen and nitro-gen species...
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Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx
... young seedlings and vascular tissues of leaves, suchas the midrib of the cotyledon, the hypocotyl, and the root vasculature (Fig. 2E). When the plants were 2 weeks old, the GUS staining in the vascular ... Journal 27 8 (20 11) 22 96 23 06 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 22 97 In order to investigate the detailed expression pat-tern of AtHELPS, the promoter sequence was cloned and fused ... orcawu@sdau.edu.cn(Received 26 January 20 11, revised 22 April 20 11, accepted 28 April 20 11)doi:10.1111/j.17 42- 4658 .20 11.08147.x The molecular mechanism for sensing and transducing the stress signals ini-tiated...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... 3. Distribution and frequency of EGFRmutations occurring in the kinase domain in lung cancer (upper part of the figure) [ 12] and in the extracellular domain in glioblas-toma (lower part of the ... corresponding to domainsI and II. In this case, the EGFR tyrosine kinase is acti-vated constitutively without ligand binding, as in the case of EGFR vI. EGFR vIII is reported to occur in 30–50% of glioblastomas ... occur in both extra-cellular and intracellular domains of the receptor tyrosine kinases, resulting in the transphosphorylation of tyrosine residues in the C-terminal regula-tory domain. These...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... genotype-directedtherapy in this disease.KRAS mutation as a mechanism of resistance to EGFR-targeted therapy The KRAS protein is localized to the inner surface of the cell membrane. The binding of ligand to EGFRinduces ... result in reposition-ing of critical residues surrounding the ATP-binding cleft of the tyrosine kinasedomain of the receptor and thereby stabilize the interaction with EGF-TKIs.Table 2. Prospective ... ATP-binding cleft of the tyrosine kinase domain of the receptor and therebystabilize the interaction with EGF-TKIs, leading to anincrease of 100-fold in sensitivity to inhibition byEGFR-TKIs...
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Tài liệu Báo cáo khoa học: An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity pdf
... mitogen-activated protein kinase kinase family after being delivered to the cytosol by the cell-binding component of the toxin, protective antigen. The effect of cleavingthese mitogen-activated protein kinase ... mutations, K518E and E682G (Fig. 1A). Lys518 is within a patch of amino acids that has previouslybeen implicated in binding MAPKKs [22 ]. Glu6 82 is within an a-helix that also contains the amino acidsABFig. ... LF, and LF-K518E ⁄ E682G. PA and LF acti-vated the in ammasome, as determined by the loss of ABCFig. 2. LF-K518E ⁄ E682G is defective in killing RAW 26 4.7 cells and inducing the Nlrp1b in ammasome....
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx
... thatincludes a DNA-binding domain, a ligand-bindingdomain and a transactivation domain. The DNA-bind-ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... as E2F family proteins. Whereas MLL1interacts with E2F2, E2F4 and E2F6, MLL2 interacts with E2F2, E2F3, E2F5 and E2F6 [34]. Similar toE2Fs, the G1-phase regulator HCF-1 recruits MLL1 and ... promoters of cathepsin D and pS2along with ERa in an E2-dependent manner. In addition to the direct interaction of MLL2 with ERa, MLLs may interact with ERs via other MLL-interacting proteins (NR-box...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... functions of the MLL protein The MLL protein has been identified as the mamma-lian orthologue of the Trithorax protein in inverte-brates [6]. Disruption of this gene in invertebrates and vertebrates ... signature that is further enhanced by the presence of the HoxA9 protein [20 ]. Men1 bindsdirectly to the N-terminus of MLL fusions [22 ] and was essential for MLL fusion proteins binding to dif-ferent ... resulting MLLfusion proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain,...
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Tài liệu Báo cáo khoa học: Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane pdf
... quantities of protein utilizing the principle of protein- dye binding. AnalBiochem 72, 24 8 25 4.Isomerohydrolase activity of purified RPE65 O. Nikolaeva et al.3030 FEBS Journal 27 6 (20 09) 3 020 –3030 ª 20 09 ... AU) 025 5101 520 Time (min)1 .2 00.80.4A 320 (1 × 10 2 AU)0.600.40 .2 A 320 (1 × 10 2 AU)1 .2 0.8 025 5101 520 Time (min)0.600.40 .2 A 320 (1 × 10 2 AU)1 .2 0.81.0 025 5101 520 Time (min) 025 5101 520 Time ... enzymaticactivity, and this concentration was therefore employed01.0A 320 (1 × 10 2 AU)3.0 2. 0 025 5 101 520 Time (min)1 2 3 025 5 101 520 Time (min)01.0A 320 (1 × 10 2 AU)3.0 2. 01 2 311-cis retinol...
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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx
... 5-bromo-4-chloro-3-indolyl-b-D-galactopyranoside. 527 2 FEBS Journal 27 5 (20 08) 527 2– 528 5 ª 20 08 The Authors Journal compilation ª 20 08 FEBSsimplex virus glycoproteins, gB, glycoprotein H (gH), and glycoprotein ... (2% formaldehyde and 0 .2% glutaradehyde). The cells were then washed with NaCl ⁄ Pi and permeabilized with 2mm MgCl 2 , 0.01% deoxycholate and 0. 02% NonidetNP-40 for 20 min. After rinsing with ... induced postentry before entry with the involvement of nectin-1. An interesting finding of the current study is that F-actin synthesis can be important for entry, asactin depolymerizers...
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Tài liệu Báo cáo khoa học: Poly(silicate)-metabolizing silicatein in siliceous spicules and silicasomes of demosponges comprises dual enzymatic activities (silica polymerase and silica esterase) doc
... bonding between the imidazole nitrogen of the conserved His and the hydroxyl of the active-siteSer increases the nucleophilicity of the Ser oxygen, facilitating attack of the hydroxy group on the ... condensation of tetraethoxysilane (TEOS) have been determined; the catalytic triad is histidine (His), asparagine (Asn) and serine (Ser) [4, 12] . In the active center of silicatein, the hydroxyl group of ... non-saturating conditions). The Michaelisconstant (Km) was determined using this value [27 ], and was calculated to be 22 .7 lm. In comparison, the Kmvalue for human recombinant cathepsin L(EC 3.4 .22 .15),...
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