... dictated, at least in part, by the particularpathology. Chronic back pain, for example, is associated with a loss of bilateral dorsolateralprefrontal cortex and unilateral thalamic gray matter ... lay the foundation for a clear and accurate representation of spatiotemporal coding of pain in the brain, with the ultimate goal of correlating neural activity with distinct cognitive and behav‐ioral ... a temporal, as well as a spatial, cerebral representation of pain [53]. They’ve suggested that in the context of acutethermal pain activity in the anterior insula, nucleus accumbens (NAc), and...