... decrease in the amount of precipitation in the presence of high concentrations of Arg-HClin the absence of the chaperone precluded analysis of the effect of this concentration on the protectiveability ... analysis of the effect of these concentrationson the chaperone activity of aB-crystallin (Fig. 4B,C).None of the compounds had an effect on the morphol-ogy of the amyloid fibrils formed (data ... determined by a number of fac-tors, including the rate of unfolding, the amino acidsequence of the protein, the experimental conditionsand the nature of the intermediate state(s) that form[1,2]. Disordered...