Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... arginine and cytoplasmicdomain of GPVI are necessary for association with the FcR c-chain. Moreover, the FcR c-chain is necessary and sufficient to initiate the signalling events after GPVIengagement, ... of GPVI and the signalling pathways. Many FcRs and their associated b and c-chains bind to each other through the transmembranedomain resulting in a receptor complex that is able to signalinside ... the FcR c-chain. These results demonstrate that reconstitutionof the GPVI–FcR c-chain complex in cells expressing the necessary signalling network is sufficient to initiate signalling events in...
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Tài liệu Báo cáo khoa học: "Bilingual Terminology Acquisition from Comparable Corpora and Phrasal Translation to Cross-Language Information Retrieval" pptx
... se-lected and misleading candidates are discarded.2.3 Phrasal TranslationQuery translation ambiguity can be drastically mit-igated by considering the query as a phrase and re-stricting the single ... Bilingual terminology acquisition from targetlanguage to source language to yield a secondtranslation model, represented by similarity vectorsSIMT →S.- Merge the first and second models to yield ... through the WWW The WWW can be considered as an exemplar lin-guistic resource for decision-making (Grefenstette,1999). In the present study, the WWW is exploited in order to re-score the set...
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Tài liệu Báo cáo Y học: The glucose-specific carrier of the Escherichia coli phosphotransferase system Synthesis of selective inhibitors and inactivation studies pptx
... the only analogue that inhibits EIIGlc by binding to the high-affinity cytoplasmic binding site and also strongly inhibitssugar uptake mediated by this transporter. The most potentinhibitor in vitro,methyl6,7-anhydro-D,L-glycero-a-D-gluco-heptopyranoside ... EIIGlc,rather than binding of Glc, enhanced the reactivity ofCys421. As Cys421 is the only invariant cysteine in homologous transporters and also the only essential cysteinefor IICBGlcactivity [39], ... protect against inactivation. To the contrary, the presence of Glc slightly sensitized EIIGlcfor inactivation by the isothiocyanates 1e and 3d. On the other hand, the rate ofinactivation by bromoacetyl-Glc...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... made by introducingan NsiI site at the translation start point of galA and by thencloning a fragment, starting at this NsiI site and containing the galA gene and approximately 700 bp 3¢-flanking ... degradation of both linear and L-arabinose-substitutedgalactan side chains of pectin. This is in agreement with aprevious study in which the synergy of enzymes degrading the pectin side chains was studied ... on the activity of the other enzymes involved in the degradation of these side chains.DISCUSSIONA. niger galA is highly similar to the b 1,4-endogalactanaseencoding genes from A. tubingensis...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... equivalent to the Oe1andNe2ofthemissing Gln30. Interestingly, replacement of this residue by Glu had little effect but replacement by Lys yielded anenzyme too unstable to purify [30]. In E. coli, ... spectrophoto-metrically by its inhibitory action on the superoxide-dependent reduction of cytochrome c by xanthine-xanthineoxidase as described by McCord and Fridovich [39] and Ysebaert-Vanneste and ... hydrogen peroxide on enzyme activityHydrogen peroxide, the product of the SOD reaction, is an inhibitor of SODs and an inactivator of FeSOD. It is often used to distinguish between the two types...
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Tài liệu Báo cáo Y học: The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168 pdf
... currently investigating thispossibility. Alternatively, this enzyme may be involved in the epimerization reaction necessary for the biosynthesis of the capsular heptopyranose as alditol acetate ... deviation is due to flexibility, mainly about the glycosidic bonds. Onlyfor residue D having the D-glycero-L-gluco-heptopyranoseabsolute configuration are short inter-residue interprotondistances ... similar to that found in other Gram-negative bacteria and is necessary for the biosynthesis of the L-glycero-D-manno-heptopyranoses commonly found in LPS of many Gram-negative bacteria. The second...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... asreported previously [20]. The serine, threonine and tyrosinecontents of the hydrolysates were corrected for destructionduring the hydrolysis by extrapolation to zero time hydro-lysis. The amino acid ... content in glycine and alanine residues. It is thought to be largelyintercrystalline [42] and to provide a framework wheremineralization occurs. The soluble matrix is characterized by the predominance ... shown). This confirms the hypothesis that the silk is indeed present in two states, soluble and insoluble, the latterbeing in some way protected from dissolution in water. The peculiarity of the WSM...
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Tài liệu Báo cáo Y học: Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species pptx
... appearance of the ThDP adduct with the substratemoiety during the complex-catalyzed succinyl-CoA hydro-lysis [72] accounts for the inactivation by dihydrolipoamide in the presence of succinyl-CoA ... contribute to the mitochondrial metabolism significantly:NADH is a strong inhibitor of E3 and should thus be muchmore efficiently oxidized by the enzymes of the respiratorychain, specifically designed ... aerobicsystem. First, the complexes are inactivated by 2-oxo acid and CoA in the presence of O2(Fig. 2A) and the inactivation is not prevented by SOD. In contrast,thioredoxin which is a known thiyl...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... deposits begin to appearduring the first decades of life and severely impair visualacuity in adulthood. Their therapy is restricted to keratopl-asty and phototherapeutic keratectomy by Excimer ... staining and light microscopy. The results reported in our study are in keeping with these recent clinical reports, as theydemonstrate the capacity of forming amyloid fibrils in vitrofor all the ... processedon day 1, day 3, day 7, and day 14 by Thioflavine Tfluorescence analysis in order to determine the amount ofamyloid fibril formation.RESULTSRole of amino-acid 124Congo red stained smears...
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Tài liệu Báo cáo Y học: The RuvABC resolvasome Quantitative analysis of RuvA and RuvC assembly on junction DNA doc
... efficiency. Also,E. coli RuvA has the ability to bind to the duplex arms of the Holliday junctions after specifically binding to the Holliday junction at the crossover point.From the analysis of the ... analysis of the binding of E. coliRuvA to synthetic Holliday junctions using a variety ofbiochemical procedures. Specifically we investigatedprotein–DNA interactions involving the RuvA and RuvC ... red and blue, respectively. The view is along the fourfold symmetry axis into the concave face of the tetramer. DomainsA, B, C and D are indicated for one monomer and the dashed linesdepict the...
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