Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc

... Germany. Ó FEBS 2002 A possible mechanism of tissue factor inhibition (Eur. J. Biochem. 269) 2031 Tissue factor pathway inhibitor A possible mechanism of action Mikhail A. Panteleev, Veronica ... Veronica I. Zarnitsina and Fazoil I. AtaullakhanovNational Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, RussiaWe have analyzed several mathematical models that describeinhibition ... describeinhibition ofthe factor VIIa tissue factor complex (VIIa–TF)by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action sug-gesting that only the Xa–TFPI...

Tài liệu Báo cáo khoa học: Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis pptx

... H,Ishihara M, Yonemura H, Miyamoto S, Funatsu A, Enjyoji K, Abumiya T, Miyata T & Kato H (1994)Amino acid sequence and inhibitory activity of rhesusmonkey tissue factor pathway inhibitor ... Biology of mast cell tryp-tase. An inﬂammatory mediator. FEBS J 273, 1871–1895.38 Ohkura N, Enjyoji K, Kamikubo Y & Kato H (1997) A novel degradation pathway of tissue factor pathway inhibitor: ... Heparin antagonists are potent inhibitors of mastcell tryptase. Biochemistry 40, 7342–7349.18 Nakahara Y, Miyata T, Hamuro T, Funatsu A, Miyagi M, Tsunasawa S & Kato H (1996) Aminoacid...

Tài liệu Báo cáo Y học: Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase ppt

... end of mRNA [2,3], forming a complex with two cleaving factors and a polyadenylation factor [4,5]. The core yeast poly (A) polymerase appears tohave a molecular mass of around 63 kDa [3]. Separatedform ... polyphosphates on poly (A) polymerasePrevious experiments had shown that diadenosine poly-phosphates also stimulated the synthesis of poly (A) catalyzed by yeast poly (A) polymerase. The relativeactivity ... catalytic properties of yeast poly (A) polymerase and on the intracellular role of dinucleosidepolyphosphates, a family of compounds of increasingmetabolic and regulatory interest [7–11].MATERIALS...

Tài liệu Báo cáo Y học: DNA and RNA damage by Cu(II)-amikacin complex docx

... tRNA cleavage.Amikacin (Ami) is a semisynthetic aminoglycoside, a derivative of kanamycin A, having the B1 amino group of 2-deoxystreptamine moiety modiﬁed by acylation with4-amino-2-hydroxybutyric ... presence andabsence of hydrogen peroxide, as well as the complexautooxidation. Some of these reactions may play a role intoxic effects of amikacin.EXPERIMENTAL PROCEDURESMaterialsAmikacin and ... andSepharose-4B (Pharmacia, Sweden). Final puriﬁcation wascarried out by HPLC on TSK-gel DEAE 2SW column(Toyo Soda, Japan).Labeling of tRNAPheYeast tRNAPhewas dephosphorylated with bacterial...

Tài liệu Báo cáo Y học: Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents pptx

... Toshio Yamakawa11Department of Biochemistry, Faculty of Pharmacy, Tokyo University of Pharmacy & Life Science, Tokyo, Japan;2Yoneyama MaternityHospital, Tokyo, JapanPreviously, we demonstrated ... of the fetal membrane tissues duringthe final stage of gestation, and that any inflammatory and/oroxidative events may have a central role in the induction of trophoblast apoptosis.Pregnancy ... increases gradually duringpregnancy. The stress may serve as a signal to initiate andpropagate the inflammatory process and result in apoptosis of placental tissues. Accordingly, we investigated...

Tài liệu Báo cáo Y học: Puriﬁcation, characterization, immunolocalization and structural analysis of the abundant cytoplasmic b-amylase from Calystegia sepium (hedge bindweed) rhizomes ppt

... activitytowards starch, amylopectin and amylose (Fig. 2A) , starchand amylopectin being a better substrate than amylose. Asthese two methods are not speciﬁc for b-amylase (but alsodetect a- amylase ... Totsuka, A. & Fukazawa, C. (1996) Functional analysis of Glu380and Leu383 of soybean beta-amylase. A proposed action mechanism. Eur. J. Biochem. 240, 655–659.47. Totsuka, A. , Nong, V.H., Kadokawa, ... starch, (b) many plant b-amylasesare spatially separated from their presumed substrate (i.e.starch), and (c) inbred lines of rye lacking the abundantendosperm b-amylase germinate normally...

Tài liệu Báo cáo Y học: Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis Relation to trehalose-based oligosaccharides attached to lipid docx

... includes variouspolysaccharides such as mycolic acid–arabinogalactan andlipoarabinomannan, as well as a variety of complex glycoli-pids [1]. Among the interesting and important glycolipds are a number ... by HPLC (Fig. 3) to allowchemical characterization of each. CO3-1 was identiﬁed astrehalose by TLC as well as by MALDI-TOF MS analysis of the products obtained by permethylation and hydrolysis,andalsoby1H-NMR.Oligosaccharide ... 2,3,4,6-tetramethylgalacti-tol acetate. As the amount of CO6 available for character-ization was too low for NMR analysis, additional charac-terization was performed using various exoglycosidases...

Tài liệu Báo cáo khoa học: "Identifying Linguistic Structure in a Quantitative Analysis of Dialect Pronunciation" docx

... closely related to the one pre-sented in this paper will be described in more detail.2.1 Aggregate Analysis of BulgarianDialectometry produces aggregate analyses of thedialect variations and has ... multidi-mensional scaling. The analyses showed that resultsobtained using aggregate analysis of word pronunci-ations mostly conform with the traditional phoneticclassiﬁcation of Bulgarian dialects as ... factors are most im-portant, explaining 35% of the total amount of vari-ance. The main drawback of applying this techniquein dialectometry is that it is not directly related to theaggregate...

Tài liệu Báo cáo khoa học: "Domain-transcending mappings in a system for metaphorical reasoning" docx

... of which Anne had only a very lowdegree of conscious awareness (i. e. on whichAnne had only a very low ability to mentally op-erate in a conscious way).We assume that there are two relevant ... Cosmopolitan (216(3), USA ed.,March 1994):594) In the far reaches of her mind, Anne knewKyle was haying an affair, but "to acknowl-edge the betrayal would mean I'd have totake a stand."We ... the organizationsin question being various forms of psychoana-lytic thought-system (or theory), and a view wecall THEORY AS HOME — whereby a body of ideas, an artistic style, etc., that someone...

Tài liệu Báo cáo Y học: Novel complexes of mammalian translation elongation factor eEF1AÆGDP with uncharged tRNA and aminoacyl-tRNA synthetase potx

... 2660749,E-mail: elskaya@biosensor.kiev.uaAbbreviations: ARS, aminoacyl-tRNA synthetase;eEF 1A, eukaryotic translation elongation factor 1A (formerly EF- 1a) ;EF 1A, prokaryotic translation elongation factor ... complexes of mammalian translation elongation factor eEF 1A GDP with uncharged tRNA and aminoacyl-tRNA synthetaseImplications for tRNA channelingZoya M. Petrushenko, Tatyana V. Budkevich, Vyacheslav ... of the metabolic pathway. Deut-scher and coauthors revealed that aminoacyl-tRNA andtRNA were never free in the cytoplasm of the eukaryoticcell [10–12]. ARS and eEF 1A are supposed to play a...

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