... was
applied to a nalyse the < /b> binding < /b> of < /b> LBR to chromatin. It was
shown that the < /b> binding < /b> of < /b> LBR fragments to chromatin was
stimulated by phosphorylation in the < /b> arginine-serine repeat-
containing region by ... system
seemed to reflect this phenomenon in vivo.
Stimulation of < /b> the < /b> binding < /b> of < /b> LBR to...
... enzymes that use molecular oxygen to
oxidize their substrates by incorporating both oxygen atoms
into the < /b> reaction product. These enzymes play an important
role in the < /b> biosynthesis and catabolism ... flavonols interact with the < /b> metal centre prior
to dioxygen attack. The < /b> EPR spectrum of < /b> 2,3QD incubated
with quercetin in the < /b> absence of < /b> d...
... A201A biosyn-
thetic pathway, may be related to their counterparts of < /b> the
< /b> puromycin and hygromycin A biosynthetic pathways,
respectively.
The < /b> puromycin biosynthetic gene cluster (pur)from
S. alboniger ... shown)
[33,34]. In contrast, its similarity to type III PKSs, which
lack this domain, is scant. This domain promotes the
< /b> binding < /b> of < /b> the <...
... approximately 17 bands
(consistent with the < /b> number of < /b> hybridizing plaques/genome
in the < /b> library screens) of < /b> various intensities could be resolved
in the < /b> SstI, HindIII and EcoRI digests of < /b> the < /b> DNA from
individual ... [31] and the < /b> magni®ca-
tion of < /b> ribosomal DNA in bb
±
mutants [32].
In ®sh genomes there may be even less con...
... HSPG binding < /b> at the
< /b> cell surface is required for maintaining LPL stability.
LPL’s C-terminal domain also appears to be involved in
the < /b> binding < /b> of < /b> the < /b> enzyme to receptors such as the < /b> LDL
receptor ... In the < /b> head -to- tail orientation, the
< /b> catalytic site in the < /b> N-terminal domain of < /b> one subunit and
the...
... intersection to the < /b> left of < /b> the
< /b> ordinate. This result e xcludes an Ôequilibrium ordered b i–bi
mechanismÕ and indicates a sequential mechanism [26]. To
determine the < /b> binding < /b> order of < /b> substrates in ... is the < /b> better
coenzyme for Gro1P production. The < /b> activity of < /b> this
enzyme was regulated by the < /b> product, Gro1P,a...
... sites
and the < /b> latter one are located in the < /b> autolysis and the
< /b> interdomain loops, respectively. By eliminating these sites
by site-directed mutagenesis, their involvement in the
< /b> autolysis and autolytic ... the
< /b> presence of < /b> Ca
21
ions) that obeyed a first order kinetics
instead of < /b> the < /b> second order displayed by wild-type chymo-
tryp...
... standard
cysteine residue in the
< /b> DYANA library [53]. A pseudoatom
was included instead of < /b> the < /b> HG atom and a bridge was
formed by superimposition of < /b> the < /b> pseudoatoms on the < /b> SG
atoms of < /b> the < /b> other Cys residue, ... the < /b> formation of < /b> EGFR homodimers
and heterodimers.
In order to interpret the < /b> mechanism(s) underlying...
... to obtain the < /b> importin-a:CLIC4
NLS complex lacks the < /b> first 69 residues that corre-
spond to the < /b> flexible importin -b binding < /b> domain. The
< /b> importin -b binding < /b> domain is known to have an
autoinhibitory ... pathway after binding < /b> the < /b> import receptor, importin-a. In this
study, we have determined the < /b> X-ray crystal structure...
... DM64 binds to the < /b> myotoxins through a myotoxic/
cytolytic site distinct from the < /b> catalytic site, as already
described for the < /b> inhibition of < /b> myotoxicity by heparin [44].
At least in the < /b> case of < /b> B. ... residues on the < /b> surface of < /b> the
< /b> myotoxin and negatively charged groups in the < /b> membrane
seem to be involved. After t...