... ATP formation and the hydrolysis of ATP by the uncoupler-stimulated ATPase [50]. There-fore, as seen in Fig. 5, ATP levels may drop substan-tially after CCCP treatment. The results of the current ... [12], the assembly of the apoptosome. Upon formation of this complex, caspase-9 acquires the ability to trigger the processing and activation of the downstream cas-pase cascade, which ultimately ... specifically caused by carbonylcyanide m-chlorophenylhydrazone (CCCP), a classicprotonophore-type uncoupling agent [38], we analyzedDwm, the intracellular ATP level, and the leakage of cytochrome...