... in various organ systems. Even in organismslacking a brain, such as Caenorhabditis elegans, the nervous system plays a key role in maintaining energybalance [1–4]. In more advanced, mammalian ... increase in malonyl-CoA promotes a decrease in neuropeptide Y and agouti related peptide in hypo-thalamic malonyl-CoA while promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated ... feeding behavior and body weight. ACC, acetyl-CoA car-boxylase; AMPK, 5¢ AMP kinase; CPT, carnitine palmitoyltransfer-ase; FAS, fatty acid synthase; MCD, malonyl-CoA decarboxylase;OAA, oxaloacetate;...