... Acinetobacter in order to establish an
O-serotyping scheme, t here exists considerable interest in
investigating the LPS core regions from this genus which
obviously allows novel insights in structure, ... genus has gained increasing
importance as a causative agent of nosocomial infections
(e.g. bacteremia, secondary meningitis) in recent years [1].
As in other G ram-negative bac...
... distinguishes three structures in a
discourse structure: 1) the structure of the sequence of utterances,
2) the structure of the intentions conveyed, and 3) the attentional
state. Distinguishing ... find evidence linking the dialogue structure to
the task structure. The main point is that the structure of the
intentions conveyed in the discourse should mirror to s...
... well-defined
F
clic4nls
o
ÀF
apo
o
density, supporting the assignment of
CLIC4 NLS residues in these binding positions. This
analysis is therefore a recommended method of struc-
tural examination in other importin-a:NLS complexes
to ... the
presence of a bulky aromatic Tyr residue in the P4
binding position. Surprisingly, the Tyr205 side-chain is
favourably placed at P4, form...
... visually using coot [42]. Ion-
pair interactions were identified using distances < 4 A
˚
.
When we counted the interactions, we excluded all residues
involved in the binding of the metal cofactor.
ApeSODs ... metal
cofactor, respectively. SODs are grouped into four
classes according to their metal cofactors: copper and
zinc-containing SOD (Cu,Zn-SOD), iron-containing
SOD (Fe-SOD), man...
... chain. This phos-
phate group is linked with Asn209 by a hydrogen bond
which is not found in AppA, where a methionine is
present at this position. In the structure of G1P, a ser-
ine residue is ... recognition.
Indeed, the scissile 3-phosphate is involved in seven
A
B
Fig. 2. Model for the binding of phytate to PhyK. (A) For each of the four protein molecules in the...
... despite their lack of regular sec-
ondary structures. For instance, loop 2 is shorter in
HtA than in a-sarcin, but the structure of the remain-
ing part is the same in both proteins, including a ... be involved in membrane inter-
action. The length of the N-terminal hairpin in HtA is
intermediate between those in RNse T1 and a-sarcin,
having 20 amino acids in HtA...
... loops of a
1
-antichymotrypsin
and heparin cofactor II contain leucine instead of
arginine as P1 residues, which explains why the forma-
tion of a stable inhibitory complexes of these serpins is
not ... carcino-
genesis as well as the normal biological roles of this
interesting, emerging class of cell-surface proteases.
Structural information on the protein domains of the
TTSP...
... proteins. B. cereus thus provides a convenient model organism for
studying proteins potentially associated with the pathogenicity of the highly
infectious B. anthracis. The zinc-binding protein of ... indicates
the C-terminal part. The dimer’s formation is established by the
incorporation of the b8-strand of one monomer into a b-sheet of
the other monomer. The position of the zi...
... identification of lipopolysaccharides and
immunodeterminan ts in pathogenic strains of Haemophilis in u-
enzae; application to clinical isolates. In Mass Spectrometry in
Biology and Medicine (Burlingame, ... correlation
between t he structure of the LPS molecule wit h that of TLR
specificity remains undefined but it is clear that TLR2 is
capable of r ecognizing a w ider ra...
... A
˚
2
),whereasitissmallerin
Fig. 3. Fold of the subunit of IPDC from Enterobacter cloacae. The
PYR domain is shown in blue, the middle domain in green and the PP
domain in red. The secondary structure ... domains. The interface contains 10
hydrogen bonds in IPDC. The dimer–dimer interface
in IPDC is smaller than the corresponding interface in
ZmPDC (4400 A
˚
2
). It is...