Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATAB

Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATABASE MINE" potx

... THERE STILL IS GOLD IN THE DATABASE MINE Madeleine Bates BBN Laboratories 10 Moulton Street Cambridge, MA 02238 Let me state clearly at the outset that I disagree with the premise that ... databasesl" has resulted in this panel, which is supposed to debate the necessity of continuing work in this area rather than to debate technical issues in the are...

Ngày tải lên : 21/02/2014, 20:20

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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... synthesis was initially hindered following stearate administration and was completely interrupted at longer incubation periods. Interestingly, the interruption of TAG synthesis preceded the ... thus excluding the possibility of nonspeciﬁc inhibition of ER stress. When the available acyl-CoAs are in excess, they are channeled towards TAG synthesis. The main ﬁndings of the prese...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

... combinations are the P-loop nucleotide triphosphate hydrolase domain, the epider- mal growth factor (EGF) domain, the SH3 domain, the P-kinase domain and the domains involved in the blood clotting ... domain deletions are more com- mon at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains...

Ngày tải lên : 19/02/2014, 07:20

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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitriﬁcans pptx

... carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-reaction the aminoquinol intermediate is converted ... substrates. The lack of inhibition observed with benzylamine (Fig. 5A) in comparison to the inhibition observed with tryptamine (Fig. 5B) suggests differences in binding of...

Ngày tải lên : 19/02/2014, 07:20

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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-afﬁnity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

... determining the binding speciﬁcity towards phosphopeptides. For example, the b-sheet structure after the EF3 segment in the Src SH2 does not exist in the Grb4 SH2 domain while the insertion after the ... titration with the Grb4 SH2 domain, i.e. the binding isotherms (Fig. 4A). The ephrinB2(301–333)- pY304 peptide was found to have the strongest binding to the Grb4...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

... Aarhus, Denmark Intrinsic factor (IF) is the gastric protein that promotes the intestinal uptake of vitamin B 12 . Gastric IF from animal sources is used in diagnostic tests and in vitamin pills. However, ... analytical and therapeutic purposes. Keywords: arabidopsis; cobalamin; intrinsic factor; recombinant. Vitamin B 12 (cobalamin, Cbl) is the most complex of the vitamin...

Ngày tải lên : 21/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... on abnormalities in microsomal drug-metabolizing func- tion during the late phase of sepsis [6]. However, the underlying mechanisms involved in hepatic dysfunction during sepsis remain elusive. Among ... this increase was attenuated by GdCl 3 . Discussion Several studies have shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity...

Ngày tải lên : 14/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... repulsive interactions within the RNA molecule. The protein thereby smooths the folding energy landscape. The direction of the RNA folding reaction (either annealing or dis- placement) is then no ... annealing of the new duplex ﬁnally results in either the replacement of the original strand or the expulsion of the invading strand, according to the kinetics and thermo...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... per hour. Data points were spline-interpolated to obtain time- continuous information on net photosynthesis during the whole period of cold exposure. The rate of rafﬁnose synthesis, r Suc ﬁ Raf , ... successful metabolic engineering of freezing tolerance in plants should include such an analysis of the dynamics of metabolism to gain com- prehensive information about the effects of...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remains unclear and it is uncertain whether it has the capacity to ... as for HPRT. The DSLS results also suggest a sequential mechanism where PRPP binds ﬁrst, inducing a confor- mation change, then allowing the purine base to bind in accord...

Ngày tải lên : 15/02/2014, 01:20

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