... at higher levels in testes than ovaries. The deep interest in Dmrt1 in the field of sex deter-mination in fish came with the discovery of a dmrt1homologue on the Y chromosome of the fish medaka(Oryzias ... of Sry is translated into cellular structure and organ morphology. Interestingly, Dmrt1, the ancestor of Dmrt1bY, is one of the downstream effec-tors of Sry in the male pathway. In medaka, the ... Doublesex- and Mab-3-related (DM)domain. Being a noncanonical cysteine-rich DNA-binding motif, this domain has two highly intertwinedfinger structures that chelate one zinc ion each, and binds to the...