... conformers. The case of the nystatin A1 is interesting regarding itsinteraction with the sterols and its incorporation intomembranes. Unlike to filipin III, a polyene antibioticbelonging to the group of ... polyenes are certainly the important elementscontributing to the high structural order found in the models of pimaricin, rimocidin, candidin and vacidin A. The extended polyenes constrain the polyol ... organicsynthesis for nystatin A1 [27,28], pimaricin [29,30], rimo-cidin [31], vacidin A [32] and candidin [33].We took the advantage of the complete knowledge of the stereochemical information of these...