... 4-aminoquinolines. J. Am. Chem. Soc. 69, 1 091 –1 099 .30. Zamyatnin, A.A. ( 197 2) Protein volume in solution. Prog.Biophys. Mol. Biol. 24, 1 09 123.31. Karplus, P.A. ( 199 7) Hydrophobicity regained. ... regained. Protein Sci. 6,1302–1307.32. Main, A.R. ( 197 9) Mode of action of anticholinesterases. Phar-macol. Ther. 6, 5 79 628.33. Fersht, A. ( 199 9) Structure and Mechanism in Protein Science,pp. ... applicable. There is no change in bkcatwith pH for A328W.BuChEkcatbkcatResidue volume(A˚3 ) HydrophobicitykH(min )1 ) kA(min )1 )pKakH(min )1 ) kH(min )1 )pKaA328G 2000 ± 1100...