Tài liệu Báo cáo khoa học: "Organizing Encyclopedic Knowledge based on the Web and its Application to Question Answering" ppt

... improved, and the coverage was comparable with that for the Nichi-gai dictionary. On the other hand, in the case where random choicewas performed, the Nichigai dictionary and the Web- based encyclopedia ... Organizing Encyclopedic Knowledge based on the Web and its Application to Question AnsweringAtsushi FujiiUniversity of Library and Information Science1-2 Kasuga, Tsukuba305-8550, ... the description.For the second type of question, human examineeswould search their knowledge base for the descriptionof each of four candidate terms. Then they wouldchoose the candidate term...

Tài liệu Báo cáo khoa học: Identiﬁcation of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae docx

... critical contributionof Utr1p to growth in low iron medium. The contributions of the othertwo enzymes were also demonstrated; however, these were observed only in the absence of the critical contributor, ... mitochondrial iron and is defective in the mitochondrial Fe–S cluster-contain-ing enzymes [2]. The disruption of POS5 increasesframe-shift mutations in the mitochondrial DNA [3].However, the ... single,double and triple mutants, which was unexpectedly found to be viable, forUTR1, YEF1 and POS5 demonstrated the critical contribution of Pos5p to mitochondrial function and survival at 37 °C and the...

Tài liệu Báo cáo khoa học: "DEPENDENCIES OF DISCOURSE STRUCTURE ON THE MODALITY" potx

... physically identify the piece. According to the theory, the speaker ' s intentions conveyed by the elliptical question include i) the speaker's wanting to know whether some relevant ... the propositional content of the communicative acts. In addition to the domain actions, pilot data led us to include an action of "physically identifying the referent of a description" ... located in the same room as the apprentice, vocally transnitted the expert's communication to the apprentice, and typed the apprentice's vocal response to the expert. The findings...

Báo cáo khoa học: "A Case Analysis Method Cooperating with ATNG and Its Application to Machine Translation" pot

... complement, and the word next to the conjunction is a pronoun. If the pronoun is a subjective case, the conjunction is determined to be one between CLAUSEs. To the contrary, the pronoun being ... analysis and the other is a buffer to hold some mentioned-above constituents. The first type has two slots ; one is similar to a blackboard and registers the names of unfilled-slots. The other ... Cooperating with ATNG and Its Application to Machine Translation Hitoshi IIDA, Kentaro OGURA and Hirosato NOMURA Musashino Electrical Communication Laboratory, N.T.T. Musashino-shi, Tokyo, 180, Japan...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... °C) and 4 °C. Synthe-sized glucose 6-phosphate was converted to 6-phosphogluc-onolactone by glucose-6-phosphate dehydrogenase, and the conversion was measured photometrically by changes in the concentration ... activity of the catalysingenzyme (Vmax,A) and the enzyme speciﬁc substrate afﬁnity,expressed by Km,A. It also depends on the concentration of the reaction product and the dissociation constant ... assessment of the trajec-tory of interconversion rates as a function of time ofcold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions with...

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... (ER) stress, and promotion of cell death, mainly by apoptosis [6–12]. On the other hand, unsaturated fatty acids (UFAs)were not toxic at the same concentrations and, in addi-tion, their presence ... and the Bcl-2 concentration stabi-lized at a somewhat lower level. On the other hand, the proapoptotic Bcl-2-like protein Bax was activated,as indicated by its translocation from the cytosolicfraction ... stearate-induced mitochondrialdestabilization and apoptosis.In order to further evaluate speciﬁc molecular mech-anisms contributing to induction of mitochondrialdestabilization, we analyzed...

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... order to orientHis25 for the nucleophilic attack on the substrate, the Ndatom donates a hydrogen bond to the backbone oxy-gen atom of Gly26. The other important histidine sidechain in the ... formation, and its dipole facilitatessubstrate binding as well. The hydrogen bond between the backbone nitrogen atom of Asp291 and the 3-phosphate of the substrate is the only interaction with the ... protein backbone; all other contacts are formedusing the side chains. The conserved Arg100 formshydrogen bonds with two of its side chain nitrogenatoms. Its Neatom and an Ngatom bind the scissile3-phosphate...

Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by ﬂuorescence resonance energy transfer–ﬂuorescence lifetime imaging microscopy in living cells doc

... exclusion column chromatography(Figs 1B,C and S1B,C). GAPDH–citrine and citrine–GAPDH were eluted at the position corresponding to tetramers, and no tetramers containing chimeric pro-teins and ... with the sequence SGLRSRAQASNS. The tetramericstructure of GAPDH is schematically shown on the right. The distances between the N-terminal amino acids of subunits O and P,subunits O and Q and ... Da, and PGK acts as amonomer with a molecular mass of 44 000 Da. Inmost bacteria, the genes encoding these two enzymesform an operon, and in animals, the two enzymes,together with some other...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... histone acetyl transferase involved in histone H3 K16acetylation) [147]. The interaction between the MLL1complex and MOF is particularly interesting as bothhistone H3 K4 methylation and histone ... ribosylation [8,10,26–33]. Although most ofthese modiﬁcations occur on the N-terminal tails ofhistones, some also occur on the C-terminal tails ofhistones H2A and H2B [29,30,34] and the core regionof ... Golshani A, John-ston M et al. (2003) The Paf1 complex is required forhistone H3 methylation by COMPASS and Dot1p:linking transcriptional elongation to histone methyla-tion. Mol Cell 11, 721–729.52...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... serine 2 and 5; phos-phorylation of DSIF (converts DSIF into an activator); and phosphorylation of components of the NELF com-plex, which leads to their dissociation and subsequentdestruction.However, ... all the above-mentioned MLL fusion proteins also retain the ability to bind to MEN1, the H3K79 histone methyla-tion activity of DOT1L activity is now conferred in aMEN1-dependent fashion. Thus, ... members of the MYC family and inhibits their function, for example, their ability to transcriptionally activate pro-apoptotic proteins. In the above-mentioned study, active GSK3 led to a decreasein...

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