Tài liệu Báo cáo khoa học: "You’ve Got Answers: Towards Personalized Models for Predicting Success in Community Question Answering" doc

... model.1 Introduction Community Question Answering (CQA) has re-cently become a viable method for seeking infor-mation online. As an alternative to using general-purpose web search engines, information ... Personalized Models for Predicting Success in Community Question AnsweringYandong Liu and Eugene AgichteinEmory University{yliu49,eugene}@mathcs.emory.eduAbstract Question answering communities ... user has received in the pastUH: UH more recent rating Rating for the last question before current question UH: UH avg past rating Average rating given when closing questions in the pastCategory...

Tài liệu Báo cáo khoa học:Bàn về khủng hoảng kinh tế toàn cầu và mô hình chủ nghĩa xã hội doc

... phdt trien, nhdm xdy diing mgt md hinh xd hgi nhdn bdn hdn, thdn thien vdi mdi trUdng hdn, vd cd dinh hUdng xd hdi chu nghla hdn. Vdi uy tin khoa hgc cua minh trong linh vUc phdt trien xd ... be tho'ng kinh te dfldc hinh thanh, mgt thfl tai ehinh bda, d dd kinh te tfl ban tai cbinh nim quyen thdng tri tren tfl ban san xuat. Dfldng nhfl eugc khung hoang tai ehinh hien nay ehi ... trong thdi gian gin day, tao ra khung hoang ve lUdng thUe. NhU vay khiing hoang nay gin vdi khung hoang tai ehinh do tU ban tai cbinh tim ndi diu tU mdi. Neu khung hoang tai ehinh la logic...

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Tài liệu Báo cáo khoa học: Synchronization of Ca2+ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium pptx

... interacts withF-actin via b-catenin and a-catenin; b-catenin bindsto cadherin and a-catenin, which in turn interacts withF-actin (Fig. 3A) [24]. Thus b-catenin plays a pivotalrole in the regulation ... synchronous increases in intracellular [Ca2+], as described below.Synchronous increases in intracellular [Ca2+] anddisassembly of cadherin–catenin complexesThe cytoplasmic domain of cadherin interacts ... mediated by cadherin–catenin complexes within eachcell and by cadherin–cadherin interactions between thetwo cells. The interkinetic cells adhere to each othervia cadherin–catenin complexes, and...

Tài liệu Báo cáo khoa học:Biện chứng xã hội và công cuộc đổi mới ở nước ta hiện nay docx

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Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx

... Dashedlines indicate van der Waals contacts with interatomic distances in A˚. Dotted lines indicate C-HÆÆÆO interactions. Black lines indicate interac-tions in SQV complexes. Red lines indicate interactions ... hydrophobic interactions in proteins [26]. Removing a methyl group in the proteinhydrophobic core affects protein folding and decreasesthe protein stability in mutant proteins [27]. In PR,two ... 2. Inhibitor binding site in PRWT–APV.(A) APV and PR residues in the binding sitewith alternative conformations. Omit maps for major (green) and minor (magenta) con-formations of APV, interacting...

Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc

... functions towards the circadianclock. miRNAs are single-stranded, nonprotein-codingRNA molecules, approximately 19–25 nucleotides in length. By binding to the complementary sites in the3¢UTRs ... composed of several self-sustaining feedback loops. In this study, we describe another mechanism impinging on the core compo-nents of the circadian clock. Using a forward genetic screen, we identiﬁedthe ... cycles, andtransmits information regarding its phase to multipletissue-speciﬁc clocks [1]. The molecular machineryunderlying the circadian rhythm, which is present in each individual cell, is...

Tài liệu Báo cáo khoa học: Simpliﬁed yet highly accurate enzyme kinetics for cases of low substrate concentrations ppt

... limitation is retreating,whereas the importance of accurate modeling and analy-sis approaches aiming at understanding the complexinteractions in living cells is increasing.Materials and methodsThe ... 175–201.Supporting informationThe following supplementary material is available: Doc. S1. An algorithm for the numerical calculation ofconstraining relations based on the zero-derivativeprinciple.This ... twodistinct phases. In the ﬁrst phase, c increases (ordecreases), whereas s remains essentially constant,corresponding to an initial rapid binding of S to E (ordissociation of C). In the second...

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through speciﬁc protein interactions in the methionine synthase–methionine synthase reductase complex docx

... active form of hMS. During reactivation of hMS, the FMN domain of MSR (light grey) and the C-ter-minal activation of hMS (grid-barrel) interact with the cobalamin-binding domain. For more information ... CH3-H4-folate binding-domain (black barrel) form discrete complexes with the cobalamin-binding domain (dark grey circle).hMS is inactivated approximately every 200–1000 catalytic turnovers [owing to ... cobalamin into apo-MS isenhanced through speciﬁc protein–protein interactions between the MSRFMN domain and MS.AbbreviationsAD, activation domain; AqCbl, aquacob(III)alamin; ATR, ATP:cobalamin...

Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc

... catalyti-cally inactive. In this autoinhibited conformation, theSH2 domain binds to pYion the C-terminal tail, andthe Src homology 3 (SH3) domain binds to the linkerbetween the SH2 and kinase domains ... kinase.Evidence for an intermolecular mechanism involvingtwo kinase domain tyrosine residues. J Biol Chem 271,17519–17525.25 Brasher BB & Van Etten RA (2000) c-Abl has highintrinsic tyrosine kinase ... traction to ﬁbronec-tin-coated beads adhering to the cells. As ﬁbronecitonbinds to integrins, the local pulling force stimulatedintegrins that subsequently activated Src. Intriguingly,the local...

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of ﬂavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

... & Medina M (2004) Role of neighboringFMN side chains in the modulation of flavin reductionpotentials and in the energetics of the FMN:apoproteininteraction in Anabaena flavodoxin. Biochemistry ... ferredoxin; Fdox,oxidized ferredoxin; Fdrd,reducedferredoxin; Fld, flavodoxin; Fldhq,hydroquinone flavodoxin; Fldox,oxidized flavodoxin; Fldsq,semiquinone flavodoxin; FNR, ferredoxin–NADP+reductase; ... optimal for electron transfer. Such obser-vation, in agreement with docking analysis [110], sug-gests that the flavin atoms might be mainly involved in the interaction and be solely responsible for...

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