Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in

Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf

... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332,Suntec, Singapore, 2-7 August 2009.c2009 ACL and AFNLP1...

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Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf

... the proteins. We examined the stability of ATN1-Q19 and -Q77 by inhibition of protein synthesis. Ateach time point, equal amounts of protein were sepa-rated in gels, and these were examined by ... accumulation of mF2 in the cytoplasmicmembrane ⁄ organelle fraction.Cleavage of ATN1 into mF2 in the brain tissues of DRPLA patientsWe next assessed the proteolytic processing of ATN1 in the brain tissue ... C-terminal F2 fragment. Interestingly, thegeneral caspase inhibitor Z-VAD-FMK increased theaccumulation of the C-terminal F2 fragment in the cel-lular model of DRPLA. Caspases, a family of cysteineproteases,...

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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... notrepress the level of PPARc protein in committed prea-dipocytes under physiologically relevant conditions.Expression of miR-27 is elevated in obese mice In order to gain insights into the potential ... biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined the expression of miR-27 in the genetically obese ob ⁄ ob mice. Theexpression levels of both miR-27a ... Wefurther investigated the kinetics of miR-27 expressionduring adipogenesis using quantitative real-time PCR.As shown in Fig. 1C,D, expression of both miR-27aand miR-27b decreased by ‡ 50% within...

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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... interact with a number of functionalgroups, including the aromatic side chains of someamino acids, through a stacking mechanism [42]. Theinteraction of arginine with aromatic amino acids of aB-crystallin ... of insulin.ACBFig. 2. aB-crystallin protects against theDTT-induced aggregation of insulin, and thisactivity is enhanced by Arg-HCl. Insulin(, 0.25 mgÆmL)1) was incubated at 37 °C in ... overallactivity of chaperone proteins. Of the target proteinstested, Arg-HCl was found to speciﬁcally increase theactivity of aB-crystallin against DTT-induced precipi-tation of insulin at intermediate...

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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... strong, neutralizing action of the cytosolic RNaseinhibitor (cRI), a 50-kDa protein containing 16 leu-cine-rich repeat motifs [7,8]. In fact, onconase fromRana pipiens eggs [9], and seminal RNase ... electrostatic ﬁeld of differentFig. 5. Plot of the EIE values as function of rotation (r) and inclination (i) angles of RNases. The hatched axis at the bottom and right of theplots show schemes of some ... of EIE were recorded at 30° inter-vals of r from 0 to 360°;(d) the inclination of the dimer major axis with respect tothe z axis, hence to the membrane plane, was changed (byinclination of...

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Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf

... extension to the protein kinase folds backon the kinase domain and interferes with the substratebinding sites. In the case of the titin and twitchinkinases, the autoinhibitory sequence acts ... PhKcsubunit encodes a C-terminal extension to the proteinkinase domain and treatment of the kinase withKeywordscalmodulin; kinase regulation; protein–protein interaction; NMR spectroscopyCorrespondenceJ. ... hexadecameric enzyme consisting of four copies of four subunits: (abcd)4. An intrinsic calmodulin (CaM, the dsubunit) binds directly to the c protein kinase chain. The interaction site of CaM on c has...

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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

... evidence thatN-glycans, in particular their terminal structures, areinvolved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA.Transport of GABA by GAT1 across ... blotting. Either anti-GFP mAb MAB2510 or anti-GAT1 pAb was used for theimmunostaining. The protein bands obtained in westernblotting were analyzed by phosphoimager scanning. Thetotal protein of ... 1-deoxymannojirimycin (dMM). Thisindicates that N-glycosylation, but not terminal trimming of the N-glycansis involved in the attainment of a correctly folded and stable conformation of GAT1. All...

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Tài liệu Báo cáo khoa học: "Robust Conversion of CCG Derivations to Phrase Structure Trees" pdf

... rule(pair of combining categories) in the CCG derivation.The PTB tree is constructed from the CCG bottom-up, creating leaves with lexical schemas, then merg-ing/adding sub-trees using rule ... 1991) using theCollins (1997) parameters. Our approach leads to in- creases on all metrics of at least 1.1%, and increasesexact sentence match by over 11% (both absolute).Many of the remaining ... performance of theCCG parsers is approaching that of the Petrov parser.5 ConclusionBy exploiting the generalised combinators of theCCG formalism, we have developed a new method of converting CCG...

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Tài liệu Báo cáo khoa học: "Fixed Length Word Suffix for Factored Statistical Machine Translation" pdf

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Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf

... LinguisticsImproving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural Language Processing (NLP) ... Part -of- speech tags of the three words preceding the medical term and the three words following it. 312Lexico-Syntactic Features: We also defined features representing words corresponding...

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