Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailﬁsh skin are identical to their plasma counterparts doc

... produce proteins that are identical to circulating plasma AFPs. Although all fish examined consistently express antifreeze mRNA in skin tissue, there is extreme individual variation in liver expression ... isolated plasma proteins [11]. Dusky snailfish also express the same type I AFP in skin tissue that is circulating in their blood(Table 1).Expression of snailfish type I AFPs in skin tissue R. ... frozen in liquid nitrogen and stored at )70 °C. Skin library construction and screeningTotal RNA from Atlantic snailfish skin tissue was isolatedusing TRIzolÒ reagent (Invitrogen Canada Inc, Burlington,ON,...

Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf

... theaVb3 integrin, because it is also reported to suppresscollagen I- induced activation of proMMP-2 [8].Another MMP inhibitor, reversion-inducing cysteine-rich protein with kazal motifs (RECK) is ... ofendogenous inhibitors regulate the activity of MMPs;a2-macroglobulin and four tissue inhibitors of metallo-proteinases, TIMP-1 to TIMP-4 [2]. In order to iden-tify potential drug targets, it is important ... their inhibitors in several cell lines [10]. The protein itselfhas no known enzymatic activity, but binds to distinctintracellular target proteins and regulates speciﬁc func-tions involved in tumour...

Tài liệu Báo cáo khoa học: "TYPE-RAISING AND DIRECTIONALITY IN COMBINATORY GRAMMAR*" pdf

... ing positional variables including the distinguished position, as in (22) and (23). At the point when the combinatory rule applies, the constraint implicit in the distinguished position must ... constraint, excluding all combinations with or into NP, is included in the program, in order to force type- raising and exemplify the way in which further constrained rule-instances may be specified. ... in which the directional constraints are here grounded in relative string position, rather than being primitive to the system, the present proposal avoids certain difficulties in the earlier...

Tài liệu Báo cáo khoa học: "Type-Driven Semantic Interpretation of f-Structures" pptx

... operator. Further- more, this investigation indicates that an additional description-by-analysis mechanism is needed within a codescription approach in order to handle cases 2This situation, ... global binding and/or scoping principles, similar to the ones formulated in [Dalrymple et al., 1990]. These principles constrain the interpretation of the f-structures and their parts if special ... A Simple Top-down Type- driven Interpretation Algorithm In order to sketch how we can achieve a decompo- sition of an f-structure which is sufficient for its in- terpretation, we first introduce...

Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efﬁciency doc

... affinitysite) and six calcium-binding sites, three of which are high-affinity binding sites responsible for enzyme sta-bility and three are low-affinity sites regulating the cat-alytic activity ... by interacting together. Additionally,fusing PhyH-DI to a single-domain phytase appears to be an efficient way to improve the activity of the latter.IntroductionPhytate (myo-inositol-1,2,3,4,5,6-hexakisphosphate, ... phosphate media,three strains with phytase activity were isolated fromthe alpine tundra soil of China No. 1 Glacier in Xinji-ang, China. Strain HJB17 exhibited the greatest phy-tase activity, 0.33...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... fatty acids gives rise to ATP and NADH, and inhibits isocitrate dehydroge-nase, thereby increasing the level of citrate which is in equilibrium with isocitrate. Citrate exits the mitochon-dria and ... AMP-dependent proteinkinaseAMPK, a nutrient-sensitive kinase, plays a pivotal role in mammalian energy metabolism [25,26]. AMPK wasinitially identiﬁed as the kinase responsible for inhibit-ing ACC and ... role in brainenergetics. Although most cells containing mitochon-dria maintain some ability to beta-oxidize long-chainfatty acids, adult neurons do not robustly oxidizelong-chain fatty acids...

Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf

... features characterizing DRPLA are cytoplasmicinclusions, which are immunoreactive to ubiquitin andATN1 antibodies, and also include nuclear inclusions in the DRPLA brains [2,26]. In the present ... HEPES-buffered saline (pH 7.4), 1%SDS (HBS-SDS) with protease inhibitors. To determinethe molecular basis for increasing the amount of ATN1,the stability of ATN1-Q19 or -Q77 was examined byinhibition of ... with the proteasome inhibitorsMG-132 (10 lm; Peptide Institute, Osaka, Japan), lactacystin(50 lm; Peptide Institute), calpain ⁄ proteasome inhibitorALLN (0.2 lm and 20 lm; Roche Diagnostics),...

Tài liệu Báo cáo khoa học:Bàn về khủng hoảng kinh tế toàn cầu và mô hình chủ nghĩa xã hội doc

... TBCN. Vi the ein phan tich va di xa hdn trong tfl duy. Cuge khung hoing tai chi'nh ngay nay gin lien vdi each ma be tho'ng kinh te dfldc hinh thanh, mgt thfl tai ehinh bda, d dd kinh ... NhU vay khiing hoang nay gin vdi khung hoang tai ehinh do tU ban tai cbinh tim ndi diu tU mdi. Neu khung hoang tai ehinh la logic eua CNTB thi khung hoang lUdng thUe eung la logic eua CNTB ... xa hgi keu ggi dieu nay xay ra lien tue. Mdi nam khung hoang sinh thai lai den gin hdn. Ta dang tren tiu Titanic, ai cung gap nguy hiem ngay ca ngfldi ngdi hang ghe diu. Ve chu nghia tii do...

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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx

... E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 expression pattern is more ventral than dorsal at this stage (D).(B) ... onchromatin. In the absence of HSF4, histone H3K9methylation is induced and HSF1 binding is reduced,indicating that HSF4 facilitates HSF1 binding viachromatin remodelling. Heat shock genes are notHSF4 ... from further mechanisticinvestigations. HSF2 could either directly interplaywith HSF1, if it is expressed in the oocyte, or indi-rectly in uence oogenesis if expressed in ovarian cells(such...

Tài liệu Báo cáo khoa học: a-Defensins increase lung ﬁbroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc

... b-catenin, and collagen synthesis induced by a-defensin-1 and a-defen-sin-2 were prevented by p38 mitogen-activated protein kinase inhibitorSB203580 and phosphoinositide 3-kinase inhibitor LY294002. ... resulted in an increase in collagen content in the culturemedium, which corresponds to changes in intracellularcollagen -I protein content. In addition, quercetinprevented an a-defensin-induced increase ... pathway in a-defensin-induced increases in the proliferation and collagen syn-thesis of lung ﬁbroblasts using quercetin. Quercetin,which inhibits the Wnt ⁄ b-catenin signaling pathwayWOsiRNAControlsiRNAβ-cateninsiRNAβ-cateninGAPDH0...

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