Tài liệu Báo cáo khoa học: Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans pptx
Tài liệu Báo cáo khoa học: Control of the coagulation system by serpins Getting by with a little help from glycosaminoglycans pptx
... concentration of AT and the rates of interaction in the presence and absence of hep-arin pentasaccharide (Table 1), one can calculate that the half-life of enzyme activity in the absence of hep-arin ... the mechanism of action of these serpins andhave significantly added to a wealth of biochemical and biophysical studiescarried out previously. A major feature of these serpins is that they areunder ... inactivation (generally) of the serpins, and, in the case of the anticoagulant serpins, a lowering of the effective concentration of the serpins and therefore diseases such as thrombosis [8].AntithrombinAntithrombin...
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Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt
... concentrations are summarized in Fig. 4A. The data clearly show that a sharp peak (quick up–downconformational change of SERCA) was rarely observedand that the lifetime of the elevated conformation ... from the cytoplasm by the Ca2+-pump (Ca2+-ATPase) [3,4], which accu-mulates Ca2+inside the SR against its concentrationgradient. The importance of the SR Ca2+-pump wasrealized in the ... whichwas less than a few SERCA molecules per lm2, owingto the partial formation of 2D crystals. These wereused for FSAFM analysis. The quality of the mem-branes was always ensured by SDS ⁄ PAGE,...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... during the course of infection, as indicated. H. pyloriexpresses several adhesins such as BabA, BabB, SabA, AlpA and AlpB, as well as OipA, which mediate apical binding of the bacteria (1).Attached ... phos-phorylating CagA in the EPIYA-motifs, inhibition of Src by CagAPYgenerates a classical negative feedback-loop that appears to control the amount of intracellu-lar CagAPY. Cortactin, ezrin and vinculin ... domain in the amino-termi-nal region of CagA [28]. In particular, CagA induces the ubiquitination and degradation of RUNX3,thereby extinguishing its ability to inhibit the transcrip-tional activation...
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Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx
... coim-munoprecipitation, tetraspanin 12 was identified as aninteraction partner for ADAM10 that enhances a- sec-retase shedding of APP, probably by regulating matu-ration of the prodomain of ADAM10 [22]. The ... aetiology of AD.ADAM10 and tumour necrosis factor a (TACE): the ill-matched coupleThree members of the ADAM family have been shownto act as a- secretase [8,36,37]: ADAM9, ADAM10 andADAM17 (TACE). ... phospholipase A and arachidonic acidincreased APPs -a production most likely by enhancingsubstrate availability at the cell surface [101].Another approach to activate ADAM10 could rest onnoncovalent...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... sites in the cyto-plasm. Signaling from internal membranes is nowconsidered to be an important aspect of the spatialand temporal regulation of signaling pathways, e.g. the Ras ⁄ MAPK pathway [38,39]. ... dephosphorylate the Tyrand Thr residues in the activation loop of MAPKs andthereby attenuate signaling [17,19]. In addition, there is a group of low molecular mass DSPs that lack the regu-latory ... reduced carboxamidomethylated and maleylated lyso-zyme as substrate, and phosphatase activity was measured. The results (shown as activity relative to wild-type phosphatase) are the mean of two...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... 2435–2447.100 Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC,Thiele DJ & Nakai A (1999) The mammalian HSF4gene generates both an activator and a repressor of heat shock genes by alternative splicing. ... C-terminal activatordomain in yeast heat shock factor: independent control of transient and sustained transcriptional activity.EMBO J 12, 5007–5018.35 Nakai A, Tanabe M, Kawazoe Y, Inazawa J,Morimoto ... inmany cells and under different circumstances and thatthey are capable of interacting with each other. The physical and functional interactions may therefore pro-vide another layer of control for...
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Tài liệu Báo cáo khoa học: Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR docx
... PA-oligosaccharides,GalNAca1-3(Fuca1-2)Galb1-3(Fuca1-4)GlcNAcb1-3Galb1-4Glc-PA and Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6(Neu5Aca2-3Galb1-3(Neu5Aca2-6)GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Mana1-3)Manb1-4GlcNAcb1-4Glc-NAc-PA ... glycan Neu5Aca2-6Galb1-4GlcNAcb1-2Mana1-6(Neu5-Aca2-3Galb1-3(Neu5Aca2-6)GlcNAcb1-4(Neu5Aca2-6Galb1-4GlcNAcb1-2)Ma na1-3)Manb1-4GlcNAcb1-4GlcNA-PAwas used as a control sugar to determine the ... spectra of SAIL and ULAt3g16450.1Although the concentration of the SAIL protein waslower than that of the UL protein by a factor of three(SAIL, 0.2 mm; UL, 0.6 mm), the NMR spectra of SAIL At3g16450.1...
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Tài liệu Báo cáo khoa học: Switching of the homooligomeric ATP-binding cassette transport complex MDL1 from post-translational mitochondrial import to endoplasmic reticulum insertion pptx
... Fullerton, CA, USA). Km ATPvalueswere derived by fitting the data to the Michaelis–Mentenequation. Specific inhibition of the ATPase activity was ana-lyzed at various concentrations of vanadate, ... modification is anartifact of Edman degradation or whether this deami-dation is catalyzed by a N-terminal amidase duringmitochondrial translocation.We next examined the membrane targeting of MDL1 ... diluted after translocation into the externalmedium. By contrast, many intracellular transport sys-tems have been characterized in detail by means of uptake assays; for example, the transporter associatedwith...
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Tài liệu Báo cáo khoa học: Analysis of the molecular dynamics of medaka nuage proteins by fluorescence correlation spectroscopy and fluorescence recovery after photobleaching doc
... primers5¢-GGAGATCTAAAATGGACGACTGGGAGGAAGA-3¢and 5¢-GCGAATTCGTTGAAAACTTTTAATTATCAGGAGAAAAC-3¢,5¢-CGAGATCTAGCATGTCAGACGTGGAGTCTGGA-3¢ and 5¢-GCGAATTCGCAACCAAAGACAACCTGGTTTTAATGTTTTGA-3¢, and 5¢-CGAGATCTGAAATGAACGAGCTGCGTATGCCGAA-3¢ ... 5¢-GCGCTAGCTAATACGACTCACT ATAG GGA GATC TAAA ATGG AC GACTGGGAGGAAGA-3¢ and 5¢-GCGAATTCGTTGAAAACTTTTAATTATCAGGAGAAAAC-3¢. This PCR frag-ment has a T7 promoter for RNA synthesis. Capped RNAwas ... 5¢-CGAGATCTGAAATGAACGAGCTGCGTATGCCGAA-3¢ and5¢-GCG AATTCAAC ACAAGAG TTGT TTTATAT TGAACCCA-3¢, respectively. The PCR product was digestedand ligated into the multiple cloning site of pEGFP-Cl(Clontech,...
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Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... (5¢-GACAACACTTTTGTCTACATGTTGGGACTGAAAGG-3¢)orFNRC266M (5¢-GACAACACTTTTGTCTACATGATGGGACTGAAAGG-3¢) and FNRlw1 (5¢-GTAATCTATCTACAGAATACAGGAGGGTGATA-3¢) as primers and plas-mid pCV105 [63] as template. In addition, ... oligonucleotidesFNRup1 (5¢-AACAAGTTCAAACCTAAGGAACCATACG-3¢) and FNRC266Llw (5¢-CCTTTCAGTCCCAACATGTAGACAAAAGTGTTGTC-3¢) or FNRC266Mlw(5¢ -C CTTTCAGTCCCATCATGTAGACAAAAGTGTTGTC-3¢) were used as primers in a second ... (5¢-ACTTTTGTCTACATGTGTGGAGTGAAAGGAATGG-3¢), FNRC26 6A (5¢-ACTTTTGTCTACATGGCTGGACTGAAAGGAATGG-3¢), FNRC266AL26 8A (5¢-ACTTTTGTCTACATGGCTGGAGCGAAAGGAATGG-3¢) or FNRG267V (5¢-ACTTTTGTCTACATGTGTGTACTGAAAGGAATGG-3¢)...
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