... 656–677.
Mapping of transcobalamin using antibodies S. N. Fedosov et al.
3898 FEBS Journal 272 (2005) 3887–3898 ª 2005 FEBS
Mapping the functional domains of human transcobalamin
using monoclonal antibodies
Sergey ... on the functional activ-
ity of TC. Arrows show the hypothetical
movement of the domains after attachment
of Cbl, see the main te...
... certain
domains of the protein decrease the SOD-like activity of the
protein. The domains deleted were based on the epitopes of
the antibodies that had a clear effect on SOD-like activity of
PrP. The mutants ... on the SOD-
like activity of PrP.
Production of deletion mutants of PrP
On the basis of the results with antibodies, a series of PrP
mutan...
... and
regulators of other enzymes in the human nucleotide
metabolism (Table S1). The library can then be seen to
constitute the specific metabolome of the nucleotide
metabolism, which would be the most ... respectively, of that of HPRT. This low activity
could be explained by the fact that PRTFDC1 has a Gly in the position of
the proposed catalytic Asp of HPRT. In P...
... resonances
without the concomitant appearance of other signals
in other parts of the spectrum. This result could be a
consequence of the paramagnetic properties of Fe(II),
or it might arise from the presence of ... Fe
3+
Addition of Fe
2+
induced the displacement of several
resonances in the [
1
H,
15
N]-HSQC NMR spectrum of
CyaY, but the most striking consequenc...
... [14]. The lack of characterization of the
structural determinant of the substrate specificity of
the AtdA enzyme has thus limited its development as a
biocatalyst for the bioremediation of a wide ... reported which
of the five genes control the substrate specificity of the
AtdA enzyme.
The objective of this study was to identify and probe
the residues determin...
... words. Therefore,
missing words can be used to prune the hypotheses
that are also highly related to the missing words.
Consider the hypotheses of latent vectors in ta-
ble 1 for bank#n#1. Assume there ... WMF on the definitions corpus, the
similarity of two senses s
j
and s
k
can be computed
by the inner product of Q
·,j
and Q
·,k
.
2.3 A Nuanced Sense Similarity: wmfvec
We c...
... of these questions, we will propose
a new hypothesis that describes an integrated vision of the
catalytic mechanism of MPO and LPO.
A brief survey of the absorption features
of MPO, LPO and their ... oxidize them [19]. On the other hand, this fact
does not represent proof of the presence of one or two
oxidizing equivalents on the decay product of Cpd I.
The EPR spe...
... best
IM:Type full time
IM:Title the godfather
Other the, in, that Other the, in, that Other the, in, that
Table 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of
this work is to identify the semantic labels of IMs,
i.e., the attribute names they implicitly refer to. We
use A
c
to denote the set of IM semantic labels for
t...
... al.,
2010), where the attitude of participants in a discus-
sion is inferred using the text they exchange.
Due to its importance, several researchers have
addressed the problem of identifying the semantic
orientation ... engine. The
number of hits for positive seeds, negative seeds,
positives seeds near the given word, and negative
seeds near the given word are used to e...
... checks whether required components of
the definition of the class are also present in the
description of the instance. This also permits easy
representation of modifications to the definition, ... irrelevant to the
matching process. The transformation is performed
by
means of a process of ~ inmtRntlat~nn OF the
deflnition the translation of the de/ini...