Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... examining the role of GIF in AD, linked to its initial discovery as a factor deﬁcient in the AD brain. There remains no clear con-sensus on the role of GIF in the pathogenesis of AD,and therefore ... interest in the roles of the entire MT family in the brain, with particularfocus on the role of these proteins in the injured orneurodegenerative brain.Discovery of GIFAD is a neurodegenerative ... loss in the AD brain. Further investigation of the increasedneurotrophic activity of the AD brain revealed that itcorrelated with the loss of a speciﬁc neuroinhibitory factor, rather than the...

Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx

... Values are the mean of six replicates. The speciﬁc uptake was determined by subtracting the uptake counts in the absence of inhibitorfrom the uptake counts in the presence of cocaine or S-cita-lopram, ... Todistinguish total binding from non-speciﬁc binding, cells wereincubated for 10 min in either PBSCM alone or PBSCMcontaining 200 lm cocaine for inhibition of DAT or 200 lmS-citalopram for inhibition ... supplied with 100 mm glycine, andincubated for 20 min to quench further cross-linking. The quenching buffer was removed by washing twice in PBSCM,and the cells were then lysed in lysis buffer (PBSCM,...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... 2A). The zinc ions are requiredfor the structural integrity of the protein, as mutation of any of the cysteine residues involved in zinc coordina-tion results in protein unfolding [22]. The ... to the KIX domain of the cAMPresponse element-binding (CREB) binding protein(CBP) [23], a peptide from the Win motif of MLL1bound to the WD40 repeat protein, WDR5 [24,25] and the C-terminal ... role for the MLL1 Win motif in the interaction by WDR5, substitution of arginine3765 with alanine in MLL1 abolishes the interactionbetween MLL1 and WDR5 [25,36]. Furthermore, the same amino acid...

Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

... simultaneouslyinteracts with the main phosphate of the substrate [32]. The closer positioning of the N-terminus to the mainprotein body is essential for the activity and, together with the 87–104 ... 23 diminished the midpoint of the thermal denaturation curve (Tm )by7 °Candthefreeenergy of unfolding (DGU )by1 1kJÆmol)1. These values are in very close agreement with those obtained using ... (Met1)-ONC(M23L) by the addition of AAP, as described in the Materials and methods. Completion of the hydrolysis wasconﬁrmed by the disappearance of the (Met1)-ONC(M23L) signal in the MALDI-TOF mass...

Tài liệu Báo cáo khoa học: "An ISU Dialogue System Exhibiting Reinforcement Learning of Dialogue Policies: Generic Slot-ﬁlling in the TALK In-car System" pot

... Exhibiting Reinforcement Learning of DialoguePolicies: Generic Slot-ﬁlling in the TALK In- car SystemOliver Lemon, Kallirroi Georgila, and James HendersonSchool of InformaticsUniversity of Edinburgholemon@inf.ed.ac.ukMatthew ... in- car” information sys-tem). Then we describe the major components of the system and give examples of their use. We then discuss the important features of the system in respect to the dialogue ... promising initialpolicy for CO MM UNICATOR dialogues, but the issuearises of how we could transfer this policy to new do-mains – for example the in- car do main. In the in- car scenarios the genre of...

Tài liệu Báo cáo khoa học: Steady-state and time-resolved ﬂuorescence studies of conformational changes induced by cyclic AMP and DNA binding to cyclic AMP receptor protein from Escherichia coli ppt

... decreases by about 8 A˚to 18.7 A˚onbinding of cAMP to the anti-cAMP-binding sites of the protein. The distance between the sulfur atom of Cys178 and the C9–C10 bond of the indole ring of Trp85, ... that the binding of cAMP to anti-cAMP-bindingsites of CRP leads to the increase in the structuraldynamic motion of at least Trp13, which is located in the N-terminal domain of the protein.AcknowledgementsWe ... absence of cAMP in apo-CRP, some b strands of the N-terminal domain of the protein may collapse into the cAMP-binding pocket, causing reorientation of the smaller domain in relation to the larger...

Tài liệu Báo cáo khoa học: "An Information-Theory-Based Feature Type Analysis for the Modelling of Statistical Parsing" docx

... sequencecontaining the leaf nodes of the partial parsingtree rooted by the current node, representing the final objectives to be derived from the currentnode.4.2 The corpus used in the experiment The ... headword of the node. In the following, the units of PIQ are bits. ConclusionAmong the feature types in the same structuralposition of the parsing tree, the predictiveinformation quantity of lexical ... denotes the probability of parsing tree T for the givensentence S. The task of probabilistic evaluation model in syntactic parsing is the estimation of P(T|S). In the syntactic parsing...

Tài liệu Báo cáo khoa học: "ENGLISH WORDS AND DATA BASES: HOW TO BRIDGE THE GAP" pdf

... picture of the PHLIQA set-up, by ignoring these intermediate levels. Given the distinctions just introduced, the problem raised by the discrepancy between the Eng- lish lexicon and the set of ... independently of each other (one on the basis of the possible Eng- lish questions about the subject-domain, the other on the basis of the structure of the data base about it) there must be ... problem in a sys- tematic way, different levels of semantic analysis are distinguished in the PHLIQAI program. At each of these levels, the meaning of the input question is represented by an...

Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... tissue,although they are not obese [15]. The expression of in ammatory cytokines (tumor necrosis factor- a, inter-leukin-6 and interleukin-1b) was increased in the adi-pose tissue of ANGPTL2 transgenic ... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia. Similarly, hyperleptinemia is aconsequence of the development of insulin resistance in ... Encoded by seven genes, ANGPTL1–7 all possessan N-terminal coiled-coil domain and a C-terminal ﬁbrinogen-like domain,both characteristic of angiopoietins. ANGPTLs do not bind to either the angiopoietin...

Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf

... (AdePeCbl)(an inactive coenzyme analog containing the adeninering in the upper axial ligand; a model of intact coen-zyme, AdoCbl) in the presence of ATP and Mg2+at amolar ratio of the reactivating factor ... damaged cofactorremains tightly bound to the active site. The DD-reactivating factor reacti-vates the inactivated holoenzyme in the presence of ATP and Mg2+ by mediating the exchange of the tightly ... solid line), 60 min (thin long-dashed line),120 min (thin short-dashed line), 240 min (thin dotted line) and360 min (thick dotted line) of incubation, the spectrum of enzyme-bound cobalamin was...

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