... which is consti-tutively expressed in the liver, is primarily involved inthe oxidative metabolism of xenobiotics and is capable of the metabolic activation of numerous procarcino-gens, including ... pathological conditions, includingcarbon tetachloride-induced hepatic fibrosis, alcohol-induced liver diseases and hepatic ischemia ⁄ reperfusioninjury, which were implicated in the activation of ... lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, we employed GdCl3 to inactivate KCs basedon the findings of other investigators...