Tài liệu Báo cáo khoa học: 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases ppt

... 1,5-diamino-2-pentyne (DAPY). The unsymmetrical DAPY comprises both a propargyl and homopropargyl amine. DAPY was synthesized and tested as a substrate of two plant CAOs. DAPY acts as a mechanism-based inhibitor of the ... Cleveland, OH, USA 1,5-Diamino-2-pentyne (DAPY) was found to be a weak substrate of grass pea (Lathyrus sativus, GPAO) and sainfoin(Onobrychis viciifolia, OVAO) amine oxidases. Prolongedincubations, ... 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases Zbyneˇk Lamplot1, Marek Sˇebela1, Michal Malonˇ2, Rene´Lenobel2, Karel Lemr3, Jan Havlisˇ4,...

Tài liệu Báo cáo khoa học: Bacitracin is not a speciﬁc inhibitor of protein disulﬁde isomerase pptx

... insulin was analyzed in the pres-ence of the PDI a domain and DsbA, which arecapable of catalyzing the oxidation and reduction reac-tions, but lack the independent substrate- binding sitethat is ... bindingAs well as having oxidase, isomerase and chaperone-likeactivity, PDI is also able to catalyze the reduction of disulﬁde bonds. The effects of bacitracin on this activitywere examined ... bacitracin A is the most abundant, and it is mainly used as an antibiotic against infections causedby Gram-positive bacteria [9]. The antibiotic effect is based on the inhibition of bacterial cell...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... the American Can-cer Society and by NIH grant number R01CA140522from the National Cancer Institute (to MSC). Wethank Venkat Dharmarajan for a critical reading of this manuscript. We would also ... structure of the ALL1gene. Cancer Res 56, 1766–1769.12 Nakamura T, Mori T, Tada S, Krajewski W,Rozovskaia T, Wassell R, Dubois G, Mazo A, CroceCM & Canaani E (2002) ALL-1 is a histone methyl-transferase ... coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16acetyltransferase MOF. Cell 121, 873–885.17 Yokoyama A, Wang Z, Wysocka J, Sanyal M, AuﬁeroDJ, Kitabayashi I, Herr W &...

Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf

... structure,considering both regular and distorted a- helix, arecalculated in the case of Bax -a5 and % 20% in the case of Bax -a6 (Table 1). The presence of even moderateamounts of SDS (Fig. 3A, C) or triﬂuoroethanol(Fig. ... helices 5 and 6 of Bax canindependently form large lipid poresAna J. Garcı a- Sa´ez1, Manuela Coraiola3, Mauro Dalla Serra3, Ismael Mingarro1, Peter Mu¨ller4 and Jesu´s Salgado1,21 ... [34]. Both Bax -a5 and Bax -a6 were able to release high-molecular-mass dex-trans, although, as observed for the experiments withcalcein, Bax -a6 displayed a lower activity than Bax -a5 , and the...

Tài liệu Báo cáo khoa học: Arginine ethylester prevents thermal inactivation and aggregation of lysozyme pptx

... Masahiro Takagi1,21School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), Tatsunokuchi, Japan;2Innovation plazaIshikawa, Japan Science and Technology Agency ... School of Materials Science, JapanAdvanced Institute of Science and Technology (JAIST), 1-1 Asahidai,Tatsunokuchi, Ishikawa 923-1292, Japan. Tel.: +81 761 51 1657,E-mail: kshiraki@jaist.ac.jpAbbreviations: ... shows a new candidate,arginine ethylester (ArgEE), as a superior additive toprevent heat-induced inact ivation and aggregation of lyso-zyme as a model protein.Materials and methodsMaterialsBovine...

Tài liệu Báo cáo khoa học: The undecided serpin The ins and outs of plasminogen activator inhibitor type 2 pdf

... & Gliemann J (1993)Type-2 plasminogen-activator inhibitor is a substrate for trophoblast transglutaminase and factor XIIIa.Transglutaminase-catalyzed cross-linking to cellular and extracellular ... gene and is translocatedalong with BCL-2 in patients with follicular lym-phoma. PAI-2 and BCL-2 also share structural similar-ities and it was proposed that the function of PAI-2may overlap ... Human PAI-2 con-sists of a single chain protein of 415 amino acidsencoded by a 1900 bp PAI-2 transcript and is highlyhomologous with mouse and rat PAI-2. PAI-2 existspredominantly as a 47...

Tài liệu Báo cáo khoa học: "Topological Dependency Trees: A Constraint-Based Account of Linear Precedence" ppt

... Finally, cat and valencyIDassign a category and anR valency toeach node w ∈ V and must satisfy:cat(w) ∈ lex(w).catsvalencyID(w) = lex(w).valencyID(V, EID) must satisfy the valencyIDassignment ... is called ‘optional auxiliary flip’.(11) (dass)(that)MariaMariaeinen a Mannmanliebenlovekönnencanwirdwill(that) Maria will be able to love a man(12) (dass) Maria einen Mann wird lieben ... Whether this proves linguistically ad-equate in practice needs to be substantiated in fu-ture research.Characteristic of our approach is that the for-mal presentation defines valid analyses as the...

Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

... 252.221.81.41.21.610.80.60.40.20 A 600 A 600 A 600Time (h)Fig. 5. His41 is essential for Paracoc-cus pantotrophus NirF, but Asp129 is dis-pensable. Growth plots and time courses of nitrite appearance and disappearance ... in a mutant thatlacks NirF; this too is not trivial as the DnirF straindoes not accumulate readily detectable amounts of anintermediate of d1synthesis.Experimental proceduresDNA manipulationsDNA ... d1heme lacking iron and ⁄ or with the side chain satu-rated, but accessing these putative substrates is nottrivial. An alternative approach would be to seek accu-mulation of the substrate of NirF...

Tài liệu Báo cáo khoa học: It is all about resolution Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia) docx

... and autophagic cell death. Two closely related kinases,ZIPk and DRP-1, mediate trans-phosphorylation and subsequent functional activation of ZIPk. DAP5 is a translation initiation factor that ... theirbiochemical properties and intracellular localization.DAP-kinases (DAPk), Ca2+⁄ calmodulin-regulated and Ser ⁄Thr kinases, activate signaling pathways thatlead to cell death through membrane blebbing ... regulatory events.Approaching tumorigenesisThe challenge of cross-platform analysis of cancermicroarray data was presented by Roland Eils (Heidel-berg), who uses median rank scores and quantile...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... agammaglobulin-emia. A clinical and molecular analysis. Medicine(Baltimore) 75, 287–299.27 Plebani A, Soresina A, Rondelli R, Amato GM, AzzariC, Cardinale F, Cazzola G, Consolini R, De Mattia D,Dell’Erba G ... Tsukada S, Saffran DC, Rawlings DJ, Parolini O, AllenRC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T,Quan S et al. (1993) Deﬁcient expression of a B cellcytoplasmic tyrosine kinase in human ... in terms of transformation capacity, membrane localization and phosphorylation of key residues?Comparison between the activation of ITK–SYK and BTK–SYKTo determine its activation capacity, we...

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