Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx
Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx
... fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyJimmy ... difluoro-substitutions at the ortho and meta positions on P1/P1¢-benzyloxy side groups of sym-metric diol-based protease inhibitors preserve the b indingefficacy and significantly improve the antiviral potency.Materials ... crystallography to decipher the s truc-ture activity relationship of fluoro-substitution as a strategyto improve the antiviral activity and the protease inhibitionof C2-symmetric diol-based inhibitors. In...
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Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... GermanyIntroduction The phenomenon of two different sexes and conse-quently the necessity to make a developmental decisionfor an embryo to become male or female (the so-calledsex-determination process), and the ... fish, birds, mammals and corals is the dmrt genefamily [5]. The prototype members of this group offactors are the Drosophila doublesex (dsx) and Caenor-habditis mab-3 genes. The Dmrt group of ... with the discovery of a dmrt1homologue on the Y chromosome of the fish medaka(Oryzias latipes). This Y-chromosomal gene is the product of a gene duplication of the autosomal dmrt1agene and was...
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc
... acceptors,GAPDH–5aa–citrine and GAPDH–10aa–citrine,respectively, were coexpressed as shown in the FLIMimages (Fig. 3A,C) and in Table 2. On the other hand, the lifetimes of PGK–7aa–cerulean and their intracellu-lar ... 1.0–1.1a The differences between the two s1values and the two s2values were significant (P < 0.005 for s1 and P < 0.001 for s2).b The differences between the two s1values and the two ... right. The distances between the N-terminal amino acids of subunits O and P,subunits O and Q and subunits O and R areshown (B–D). FLIM analysis of the interaction between cerulean–GAPDH and citrine–GAPDH...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... AF10 and DOT1L, and thus compete with their binding to the AF4 complex.An as yet unpublished study has demonstrated that the reciprocal AF4–MLL fusion protein retains itsH3K4 HMT activity and ... forexample, HoxA7 and HoxA9. The transforming capac-ity of the tested MLL fusion constructs was alsodependent on the presence of Meis1 and Pbx proteins,as well as on the presence of Men1 and Ledgf ... Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA -binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, the FYRC...
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Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... 100 mM NaCl. The upper panels show the raw data for the heat effect during the titrations; the lowerpanels are the binding isotherms.Table 2. Thermodynamic parameters of NarG(1–15) and NarG(1–28) ... enthalpy is the sum of twoterms: the reaction enthalpy, independent of the bufferused in the experiment, and another term representing the contribution of the proton ionization of the buffer,which ... between NarJT and the NarG(1–15) peptide (Table 2). Binding reactions areoften coupled to the absorption or release of protonsby the protein or the ligand. If this is the case, the bind-ing...
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Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx
... withthiol groups, and the cadmium speciation of the wild-type and the CeMT-2knockout strain was distinctly different to the CeMT-1 and double knock-outs. Taken together, and supported by a simple ... further shells of scatterers.Although the EXAFS data were admittedly noisy, theyTable 2. Zinc and cadmium binding affinities for MTs in Caenor-habditis elegans and other species. Log K binding ... species, and the data compiledfor Zn6-CeMT-2, Cd6-CeMT-2 and Zn7-CeMT-1 inFig. 1 and Table 1 show that this was achieved byexpression in the presence of the desired metal ion.However, the...
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Tài liệu Báo cáo khoa học: An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities doc
... RNA-cleaving activity relativeto the 8–17 variant. Although the Cu2+ and ascorbatewere important for the DNA-cleaving activity of DRcDNAzyme, they did not support the RNA-cleaving activity of ... and crucial for the catalytic activity. When the C deoxyribonucleotide is inserted in the 5¢-T28G29G30-3¢ sequence of PL DNAzyme, the sequence is changed to 5¢-TCGG-3¢, which is the sameas the ... products (Pa and Pb). To map the cleavagesite of the self-cleaving DNAzyme, we used denaturingPAGE and ran the gel until the reaction products wereclearly separated (Fig. 2B). The Pa and Pbcleavagefragments...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc
... rigid and hence there is little selectivity concerning the sizeof the ion. Thus, the affinity of the different metalions in MTs is governed primarily by the thermody-namic stability of the thiolate–metal ... to the MT family and henceshares the unusual properties of their metal–thiolateclusters, there are important differences between MT3 and the well-characterized MT1 ⁄ 2 [4]. Such chemical and ... com-plete loss of the Cd3-CysS9resonances. The reporteddata indicate that the b-domain provides the binding site for the eighth equivalent of Zn(II) [and Cd(II)].Moreover, the occurrence of...
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Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx
... of the flap regions in the structures. The complexes with APV arein cyan, and the complexes with SQV are ingray. The arrow indicates the shiftsbetween Caatoms at the residues 50 and 51 in the ... mutations and inhibitors alter the PR structure. Here, we describehow PR recognizes the inhibitors APV and SQV bystructural rearrangements of the two beta-hairpin flaps and two 80¢s loops, and how the ... with the side chains of Val56,Leu76 and the main chain atoms of residues 77–78, and Ile32¢ showed new interactions with the side chainsof Ile47¢, Ile50 and Val56¢ in the flaps (Fig. 3A). The flaps...
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Tài liệu Báo cáo khoa học: Structural features of proinsulin C-peptide oligomeric and amyloid states pptx
... structural studies. In the presentstudy, we therefore used SDS to structurally character-ize the oligomerization process of C-peptide and ana-lyzed the formation of oligomers and their secondarystructure ... C-peptide in the presence of divalent Ca2+ and Mg2+ionsunder native conditions (B), and of 100 lMC-peptide in the presence of insulin (C) and of 100 lM C-peptide in the presence of NaCl and formamide ... proinsulin C-peptide at pH 8 and pH 3.2.At pH 8, neither the diffusion rate, nor the signal-to-noise ratio for the peptide signals in the spectrum isseverely affected by the addition of detergent...
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Từ khóa: tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngbáo cáo khoa học số loài quý hiếm tại vườn quốc gia ba bểtai lieu bao cao thuc tap khoa co khiNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíBT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ