Tài liệu Báo cáo khoa học: Use of hydrostatic pressure to produce ‘native’ monomers of yeast enolase ppt

... Use of hydrostatic pressure to produce ‘native’ monomers of yeast enolase M. Judith Kornblatt1, Reinhard Lange2,* and Claude Balny2,*1Department of Chemistry and Biochemistry, ... had to be bound to the enzyme.This article presents a study of the pressure- induceddissociation of yeast enolase in the presence of Mn2+.Wedemonstrate the ability of hydrostatic pressure to ... Native monomers of yeast enolase produced by pressure (Eur. J. Biochem. 271) 3899If Mn2+stays bound to enolase during the exposure to pressure, what happens to enzymatic activity? In order to answer...

Tài liệu Báo cáo khoa học: "Use of Mutual Information Based Character Clusters in Dictionary-less Morphological Analysis of Japanese" ppt

... how knowing the sort of each character is use- ful when tokenizing a string of characters into a string of words and when assigning parts -of- speech to them, and our method of clustering characters ... of their distributions with respect to a presumably natural class called numericals. Supposing one of a certain group of characters often occurs as a neighbor to one of the other groups of ... hierarchical clusters of words by classifying words in such a way so as to minimizes the reduction of MI. This idea is general in the clustering of any kind of list of items into hierarchical classes....

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... 11cRAL to cone photoreceptors in cone-dominant species. Identiﬁcation of an alterna-tive visual cycle will contribute to the understanding of the functional differ-ences of rod and cone photoreceptors.Structured ... absence of a metal chelator, RPE65c cat-alyzed the production of 11cROL and 13cROL fromatRE (Fig. 4A). However, in the presence of 1 mM of the metal chelator, bipyridine, the enzymatic activity of RPE65c ... 2919DiscussionCone photoreceptors have faster recovery of light sen-sitivity from desensitization than rod photoreceptors asa result of the higher regeneration rates of visual pig-ments [41,42]....

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... doublet of ITK fusesdirectly with the linker B kinase region of SYK. ThePH domain of TFKs usually binds to phosphatidylino-sitol-3,4,5-trisphosphate, thereby bringing them inclose proximity to ... 1–196) of BTK fused with the linker B kinase region of SYK(306–635 amino acids) (Fig. 2). We used two differentcell types to study the phosphorylation status of keyresidues and the capacity to ... binding and mutation to tryptophan most probably causes instability of theSH2 domain. Thus, these patients had undetectablelevels of ITK protein despite normal levels of mRNA.Consistent with...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... supply to hedge againstperiods of food shortage. Today, humans have pushedstorage too far, to the point of widespread obesity.Although obesity is preferable to starvation, this statefrequently ... regulatory step of glycolysis catalyzed byphosphofructokinase, which is used by glucose, butnot fructose. This rapidly activates AMPK rather thaninhibiting AMPK as glucose does. Therefore, fructoseand ... uponendocrine signals, although endocrine factors canimpinge on its activity. Thus, the activity of ACC isan indicator of energy surplus and is thought to beone of the mechanisms by which energy homeostasis...

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... inducesapoptosis in a Bax-dependent manner.Inhibitor of apoptosis protein familyInduction of MOMP following apoptotic stimuliresults in the release of cytochrome c and subsequentactivation of caspase-9 ... characterized by the permeabili-zation of the outer mitochondrial membrane and therelease of several pro-apoptotic factors into thecytoplasm. For mitochondrial outer membrane per-meabilization ... translo-cation from the cytoplasm to the mitochondria andpromotes survival [45]. Anti-apoptotic stimuli lead to the activation of Akt and to Ser184 phosphorylation of Bax [46]. This phosphorylation...

Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt

... andresistance to apoptosis through downregulation of tBid, providing furtherdetails on how EGF receptor and proteasome inhibitors can contribute to theinduction of apoptosis and the treatment of cancer.Structural ... changesthat occur during apoptosis. The mitochondrial release of cytochrome c and second mitochondria-derivedactivator of caspase (Smac ⁄ DIABLO) allows for theformation of the apoptosome, a complex that ... subfamily of the Bcl-2family involved in the initiation of apoptosis throughthe mitochondrial pathway. The key event in the mito-chondrial pathway is the release of proapoptotic fac-tors from...

Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc

... eachform:si¼½Si=Stot; s ¼½S=Stot; s1¼½Sa1=Stot; s2¼½Sa2=Stotð5ÞThe conservation of the total Src concentration(Eqn 4) leaves only three independent variables in thekinetic scheme of Fig. ... com-plex dynamics of Src responses can be understood interms of a simple basic model of the Src (de)activationcycle in the absence of any imposed external feedback. To explain how toggle switches ... S3C–F).This analysis of the parameter variation effects on theQSS curve is useful for experimental manipulations of the concentrations of both Src effectors and theircompetitive inhibitors (e.g. inactive...

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... appear to be due to Pgp activity. Because the over-expression of MRP 1–5 did not signiﬁcantly reduce the amount of TMRM taken up into the cells, the obstacle to uptake of rhodamines into the ... the total dye amount associatedwith the cells, including the dye adsorbed to the sur-face of the cells. To avoid complication of the uptake studies byactive pumping of the dyes into the mitochondria, ... observed in the presence of NBD-Cl doesnot appear to be due to the inhibition of Pgp. A halfmaximal effect of NBD-Cl was observed at concentra-tions of 3–5 lm, irrespective of the rhodamine concen-trations...

Tài liệu Báo cáo khoa học: A facile method for expression and puriﬁcation of the Alzheimer’s disease-associated amyloid b-peptide pdf

... system in which Ab was fused to ubiquitin. This protocol relies on the use of Ni-NTAaffinity chromatography for purification and subse-quent liberation of Ab by digestion using yeast ubiqu-itin hydrolase, ... solution. To minimize carbam-ylation of Ab, fresh solutions of ice-cold, deionized ACSgrade urea were used, and the duration of exposure to ureawas limited to less than 12 h.Purification of Ab(M1–40) ... aftertryptic digestion of the gel band (data not shown).The PCR protocol used to generate Ab(M1–40) andAb(M1–42) was designed to facilitate incorporation of familial mutants by exchange of only the middle...

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