Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... reduceslevels of mutant huntingtin and the risk of neuronaldeath. Nature 431, 805–810.97 Selkoe DJ (2004) Cell biology of protein misfolding:the examples of Alzheimer’s and Parkinson’s diseases.Nat Cell ... Trautinger F (1996) Modification of growth and tumorigenicity in epidermal cell lines by DNA-mediated gene transfer of Mr27,000 heat shock protein(hsp27). Cell Growth Different 7, 1167–1174.144 ... (1999)Dementia, gliosis and expression of the small heatY. Sun and T. H. MacRae Small heat shock proteins and diseaseFEBS Journal 272 (2005) 2613–2627 ª 2005 FEBS 2625shock proteins Hsp27 and [alpha]B-crystallin...
- 15
- 573
- 0
Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... reactions of trans-sulfura-tion through the production of homocysteine, biologi-cal methylations of DNA, lipids and proteins, and polyamine biosynthesis through the production of methionine and S-AdoMet ... result of this approach indicated the orienta-tion of 5-methyltetrahydrofolate in the MetS activesite. Figure 5 shows the superimposed structures of DHPS and 5-methyltetrahydrofolate. The model of ... TA (1991) Inhibition of vitamin B12-dependentmethionine biosynthesis by chloroform and carbontetrachloride. Biochem Pharmacol 42, R25–R28.16 Smith JR & Smith JG (1990) Effects of methylmercuryin...
- 13
- 424
- 0
Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... notshown). Inhibition of pneumococcal murein hydrolases by bicyclic amines As shown above, tropic esters of bicyclic amines wereselected and characterized by biophysical methods asstrong ligands ... analysis of ligand binding to C-LytA. (A) Con-formational changes induced by ligands on C-LytA monitored by near-UV CD with no ligand added (—) and upon addition of ligands:s, d, 2.5 and 20 mM ... FEBS Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines Beatriz Maestro1, Ana Gonza´lez2, Pedro Garcı´a2 and Jesu´s M. Sanz11 Instituto de Biologı´a...
- 13
- 465
- 0
Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx
... [51,52].The O of Ser90 and the S of Cys266 of pea FNR are closeto N5 and O4 of the isoalloxazine, which are involved inhydride transfer. The hydroxy group of Ser90 could accept ahydrogen bond and thus ... forappropriate binding of the metal ion, which remainsaccessible from the exterior (Fig. 7B). Distances betweenthe N5 and O4 of the flavin, O of Ser90, S of Cys266, O of Glu306 and O of Tyr308 indicate ... that inhibition is produced by th e interaction of the metal witha unique site present in t he reductase domain of the enzyme[13]. This domain binds one equivalent of FMN and one of FAD and, ...
- 12
- 585
- 0
Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... inactivation of G APDH being metal-ion independent, whereas inhibition of GR and LDH by H2O2occurs most rapidly in the presence of metal ions.It is proposed that the inhibition of GAPDH and GR by these1O2-generated ... its1Dgstate;1O2)isgenerated by a number of enzymatic and chemical reactions, by UV exposure, and by visible light in the presence of anumber of exogenous or endogenous cellular sensitisers.1O2generation ... protects cells against photo-oxidativedamage and cell death [62,63]. Whether the p rotectionoffered by thiols is o wing to direct scavenging of 1O2,removal of peroxides (H2O2 and/ or protein),...
- 10
- 462
- 0
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... BTK–SYK and ITK–SYK fusion proteins lead to differential phosphorylation levels of the fusion proteins themselves, as well as the downstream adapter proteins SLP76 and BLNK, in 293T and COS7 cells. ... ª 2011 FEBSMINIREVIEWTEC family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, ... sus-ceptible cells at multiple levels [62]. In resting humanCD4+T cells, the expression of ITK is extremely low and often undetectable in immunoblot analysis. Theactivation of CD4+cells, however,...
- 10
- 926
- 0
Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... all the cell linestested and the efflux of rhodamines in MRP1 over-expressing cells wasabolished by NBD-Cl, it appears that rhodamines are excluded from thesecells by MRP1. On the other hand, ... SD of four independent experiments.Fig. 4. The effect of MK571 and NBD-Cl on TMRM distribution in K562 and 2008 cell lines. K562 cells and 2008 cells were incubated in theabsence or presence of ... enhanced uptake of rhodaminedyes inhibited the efflux of these dyes from the cells.The efflux of rhodamine 123 and TMRM was inhib-ited by NBD-Cl and MK571 and, to a lesser extent, by ATP depletion...
- 12
- 651
- 0
Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... the three concentrationstested, inhibition of MTT by Ab(1–40) and Ab(M1–40) was essentially identical; similarly, the degrees of inhibition caused by Ab(1–42) and Ab(M1–42) wereindistinguishable ... E22K, E22Q and D23N), and the availability of a rapid and simpleexpression and purification protocol will facilitatelarge-scale investigations of the molecular determinants of aggregation and fibrillation. ... suppliedwith the enzyme, and contained Aba, Abb and Abcat40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP,dGTP and dTTP. The product...
- 16
- 691
- 0
Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... proteomics.Characterization of chloroplast proteins of Arabidopsisthaliana by top-down mass spectrometry. Mol Cell Proteomics 2, 1253–1260.21 Park JH, Burns K, Kinsland C & Begley TP (2004)Characterization of ... nozzle-skimmer dissociation spectra of 1 : 1,2 : 1 and 3 : 1 mixtures of 144 and 116 kDa proteins showed the corresponding molecular ions and, foreach, 11–17 different mass values of 1–10 kDa thatrepresented ... a molecular mass of 16 309.7 Da, butthis matched none of the DNA-predicted proteins. MS ⁄ MS of these ions gave the C-terminal sequence of Fig. 5. These and all other peaks of that spectrum...
- 13
- 572
- 0
Tài liệu Báo cáo khoa học: Aldehydes release zinc from proteins. A pathway from oxidative stress⁄lipid peroxidation to cellular functions of zinc pptx
... studyaddresses the reactivity of aldehydes with cysteine lig-ands of zinc in proteins. Moreover, it demonstratesthat aldehydes release zinc from isolated proteins and in cultured cells and that the released ... proposed mechanism of activationinvolves a reaction of electrophiles with the cysteineligands of Keap1, followed by zinc release [28]. Thereactions of aldehydes with MT and ADH and con-comitant ... metabolism and that zinc release and ensu-ing binding of zinc to other proteins is one aspect of the molecular actions of aldehydes that are generatedduring lipid peroxidation and metabolism of ethanol.Zinc...
- 11
- 473
- 0
Từ khóa: tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngbáo cáo khoa học số loài quý hiếm tại vườn quốc gia ba bểtai lieu bao cao thuc tap khoa co khitai lieu bao cao thuc tap tai khoa duoc benh vienNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015