... ª 2006 The Authors Journal compilation ª 2006 FEBS
Induction of uPA gene expression by the blockage of
E-cadherin via Src- and Shc-dependent Erk signaling
Sandra Kleiner, Amir Faisal* and Yoshikuni ... clear that the
expression of E-cadherin and the expression of MMPs
are inversely correlated [11,12] and that E-cadherin-
dependent cell–c...
... to the sequence of the hsp70 promoter between )206 and
)187 bp, and that mutations of this sequence abrogated the activation of
the hsp70 promoter by Hsp105b. In addition, overexpression of Hsp105b
stimulated ... Hsp105b
stimulated the phosphorylation of STAT3 at Tyr705 and its translocation
to the nucleus. Downregulation of STAT3 expression resulted in reduc...
... Model of the 3D structure of the
neutral protease from Bacillus stearothermo-
philus, including the position of the disulfide
bridge in mutant G8C ⁄ N60C. The model
was created on the basis of the ... fluorescence and CD spectra of the unfolded and
the degraded protein are nearly identical [15], the progress
curves in the presence of GndHCl reflect the dec...
... develop a broader perspective of the questions
within an analysis of the hypothesis in the con-
text of a characterization of the "how" of the
entire behavior.
By adapting HOPE for processing ... process time interval, there are
six types of serial-order process that can occur
and affect the state of the process. The most
important aspect of...
... rest of the
input data if the workflow is robust (i.e. makes
use of retry and parallelisation) and the error is
confined to a WS (i.e. it does not affect the rest of
the workflow).
An instance of ... and one of my-
Experiment have been deployed to be the Reg-
istry and the portal to share workflows and other
experiment-related data. Both have been adapted
by mo...
... reference, the
position of the sugar and of the metal in the crystallo-
graphic template 1YOE. The two ligands were modelled in
each binding site of SsCU-NH, and then the structure of
the resulting ... pro-
trudes towards the exterior of the tetramer near loop
275–288 of the opposite monomer. Therefore, the
binding and adaptation of this portion of...
... without the need for PI-3¢ kinase activity as
judged from the absence of an effect of arsenite on
PI-3¢ kinase activation and the lack of inhibition by either
wortmannin or LY 294002. Furthermore, ... uptake. Another early target of insulin
action, the activation of ERK- 1, -2 was also not activated
appreciably in response to arsenite-treatment either
(Fig. 3D).
The e...
... THP-1
monocytes. In addition, the effects of KLF4 on the
expression of SR-BI and the primary mechanism were
also investigated.
Results
HDL induces the expression of KLF4 and SR-BI in
PBMC and phorbol 12-myristate ... demonstrated the increasing
expression of KLF4 in PBMC and THP-1 cells, and
identified that induction of KLF4 by HDL
3
promoted
the expr...
... of this type exhibit the predicted
amount of binding only if the heterodimer is tethered
by the wild-type partner. By contrast, we found that, if
the heterodimer is tethered to the resin by the ... employing soluble
forms of the receptor [25,26,34], indicates that the
ectodomain of the receptor is capable of dimer forma-
tion in the absence of ligand.
Affi...
... significantly
increases the cost of the purification, and the require-
ment for HPLC increases the length and complexity of
the purification procedure. Moreover, as with the
studies by Lee et al. [21] and Subramanian ... E22K, E22Q and
D23N), and the availability of a rapid and simple
expression and purification protocol will facilitate
large-scale investigat...