... synthesisSqualeneCholesterolHMG-CoA reductaseSREBP-2NADPHPyruvateAcetyl-CoACitrateacetyl-CoAOxaloacetateOxaloacetateACLACCHMG-CoAHMG-CoA synthaseCitrateMalonyl-CoAPalmitateMalateMitochondriaFASACCSCDFatty ... dehydrogenase; PK,pyruvate kinase; ME, malic enzyme; ACL,acetyl-CoA lyase; ACC, acetyl-CoA carboxyl-ase; FAS, fatty acid synthase; SCD, stea-royl-CoA desaturase; GPAT, glycerolphosphate acyltransferase; ... Shimano H, Nakakuki M, Matsuzaka T,Nakagawa Y, Yamamoto T, Sato R, Takahashi A, Sone H, Yahagi N et al. (2005) Lipid synthetic tran-scription factor SREBP- 1a activates p21WAF1 ⁄ CIP1, a universal...