Tài liệu Báo cáo khoa học: Influence of modulated structural dynamics on the kinetics of a-chymotrypsin catalysis Insights through chemical glycosylation, molecular dynamics and domain motion analysis pptx
... 2006 The Authors Journal compilation ª 2006 FEBS 5319
Influence of modulated structural dynamics on the
kinetics of a-chymotrypsin catalysis
Insights through chemical glycosylation, molecular dynamics ... revealed structural insights into the relation between the
protein’s surface glycosylation, the resulting structural dynamic changes,
and...
... determination of flux control coefficients by
PFK, PK and LDH. The role of the las operon is dis-
cussed on the basis of the distribution of flux control
for PFK, PK and LDH.
Results
PFK has no control ... expression of the las operon two- to three-
fold the glycolytic flux will be dramatically affected.
Indeed, regulation of expression of the las operon has
Cont...
... long-range
1
H–
13
C correlation was
detected between the carbonyl carbon of the serine and
the d-CH
2
of the hOrn, which constitutes the DKP.
Therefore, putting all these long-range connections
together, ... characterization of these compounds is
growing and may result in the synthesis of specific
inhibitors based on the structure of the pathogen
siderophore [1...
... compute the frequency of all the
candidates identified in all snippets, and output the
one with the highest frequency.
4 Experiments and Evaluation
We extracted the Wikipedia titles of English and ...
translations in another language. By retrieving and
identifying such translation counterparts on the
Web, we can cope with the OOV problem.
Consider the tec...
... to
designate the phenomenon when the expression of a
gene on one chromosome depends on the pairing
with its homologous region [14]) The degree of com-
plementation in A7 depends on the size of the pro-
moter ... (indica-
ted by the thickness of the curved arrows) of the cis and trans
interactions in favor of the latter. An increase in the trans inter-...
... facility by allowing structural and “construc-
tion” searches.
2
3.1 IGT detection
The canonical form of IGT, as presented in Section 2.1,
consists of three parts and each part is on a single line.
However, ... 2009).
Running the new IGT detection on the original three
thousand ODIN documents, the number of IGT in-
stances increases from 41,581 to 189,244. We then ran...
... PGD
2
is
involved in the activation of adipogenesis and regula-
tion of insulin sensitivity in vivo. Further characteriza-
tion of the role of PGD
2
in adipocyte differentiation
and function is an important ... procedures
Generation of H-PGDS TG mice
The coding region of human H-PGDS was cloned into the
downstream sites of the chicken b-actin promoter and the
C...
... each of the
themes. The point of the SVD analysis is to discover
these themes based on co-variance between the word
frequencies. If words occur together, they are se-
mantically related and the ... A = U SV
tr
.
The S-matrix defines the themes of the reading
context. The U-matrix relates the reading context
vocabulary to the discovered themes. Finally, the
V...
... also the reason why the determination
of the spatial structure of the N-terminal domain con-
taining the Cd(II)
3
-CysS
9
cluster was thus precluded.
For a more detailed discussion of the dynamics ... to air resulted in the slow formation of a
disulfide linkage by cysteine oxidation of the a -domain
and a concominant release of one Zn ion, but the spec-
tro...
...
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