Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf

... properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes Jolita Ciapaite1,5, Stephan J. L. Bakker 2 , Michaela ... to acti-vation of AMPK cannot lead to production of ATPbecause of lack of mitochondrial ADP. As AMPK sti-mulates cellular fatty acid uptake [29 ] and the availab-ility of circulating fatty acids ... concentration was calculated as (for derivation seesupplementary data, Appendix S1): Palmitoyl-CoA and control of mitochondrial function J. Ciapaite et al. 529 8 FEBS Journal 27 3 (20 06) 528 8–53 02 ª 20 06...

Tài liệu Báo cáo khoa học: "Unsupervised Segmentation of Chinese Text by Use of Branching Entropy" pdf

... Proceedings of the COLING/ACL 20 06 Main Conference Poster Sessions, pages 428 –435,Sydney, July 20 06.c 20 06 Association for Computational Linguistics 428 0.5 1 1.5 2 2. 5 3 3.5 4 4.5 5 1 2 ... 8entropyoffset 429 4304314 32 0 0.1 0 .2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 0.55 0.6 0.65 0.7 0.75 0.8 0.85 0.9 0.95 1recallprecisionBincreaseBordinaryBmax433 0 0.1 0 .2 0.3 ... 1recallprecisionBincreaseBordinaryBmax433 0 0.1 0 .2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 10 100 1000 10000 100000 1e+06size(KB)recallprecision434...

Tài liệu Báo cáo khoa học: Metabolic gene switching in the murine female heart parallels enhanced mitochondrial respiratory function in response to oxidative stress pdf

... and medium-chain acyl-CoA dehydro-genase (MCAD) (both PPARa target genes) wasTable 1. Baseline characterization of male and female obese mice.Values are expressed for 18 20 -week-old male and ... 22 528 22 533.11 Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setc-hell KD, Schaefer E, Kajstura J, Anversa P & SussmanMA (20 01) Myocardial Akt activation and gender:increased nuclear ... electrodechamber.To test the ability of mitochondria to withstand oxidativestress, 3 mm ADP was added after state 4 respiration, and the chamber was closed and sealed for a 20 min period. As a result, oxygen...

Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx

... BilkentUniversity, Ankara, Turkey, 2 General Surgery, Ankara NumuneResearch and Teaching Hospital, Ankara, Turkey,3Department of Pathology, Ankara Numune Research and Teaching Hospital,Ankara, Turkey. E-mail: ... levels on basal levels of lymphocyte DNA damage and oxidative status, lymphocyte DNAdamage, plasma protein oxidation (PO), malondialdehyde (MDA) and total antioxidative capacity (TAC) and aluminium ... accurate quantiﬁcation of telomerase activity by TRAP – silver stain assay.PP- 425 High expression of the rad 52 gene and thecapability of tumour cells for differentiationS. A. Alexandrova and...

Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc

... (forward); 3¢-GAAAAACATCACTTC AGCATTTCGTTAATTAAC-5¢ (reverse); Asp40Asn: 5¢-GGTGTTAATTAACGAAAATAAC GAAGTGATGTTTTTCAAC-3¢ (forward); 3¢-GTTGAAAAACATCACTTCGTTATTTTCGTTAATTAACA-5¢ (reverse). Mutation ... mutants are comparable to that of the wild -type enzyme. B ased on the data, we propose that Met95Table 2. Cyanide binding rates, r edox potentials and auto-oxidationrates of the Asp40Ala and Asp40Asn ... Critical roles of Asp40 at the haem proximal side of haem-regulatedphosphodiesterase fromEscherichia coliin redox potential,auto-oxidation and catalytic control Miki Watanabe, Hirofumi Kurokawa,...

Tài liệu Báo cáo khoa học: Metabolic ﬂux proﬁling of Escherichia coli mutants in central carbon metabolism using GC-MS docx

... MDVMetabolitePEP U PEP(1)3)PEP (2) 3)PEP(1 )2) 1 PEP(1 )2) Pyruvate U Pyruvate(1)3)Pyruvate (2) 3)1 Pyruvate(1)3)Pyruvate (2) 3)OAA U OAA(1)4)OAA (2) 4)OAA(1 )2) 1 OAA(1)4)OAA (2) 4)OAA(1 )2) OGA ... was determined by comparing the MDV a of amino acids with identical carbonskeletons, and the standard deviation of these redundantdata was used for calculation of the covariance matrix Cm of ... ZnSO4Æ7H 2 O, 0. 12 g CuCl 2 Æ2H 2 O,0. 12 g MnSO4ÆH 2 O, 0.18 g CoCl 2 Æ6H 2 O, and 22 .25 gNa 2 EDTAÆ2H 2 O. Filter-sterilized glucose was added to a ﬁnal concentration of 3 g per litre. For 13C-labelingexperiments,...

Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc

... pathway.(B) Reaction catalyzed by GO on glyphosate,an alternative to the AMPA pathway ascatalyzed by GOX.Mechanisms of glyphosate resistance L. Pollegioni et al. 27 58 FEBS Journal 27 8 (20 11) 27 53 27 66 ... 5-enolpruvyl-3-phosphoshikimate synthase. US Patent 6 ,22 5,114.38 Kahrizi D, Salmanian AH, Afshari A, Moieni A &Mousavi A (20 07) Simultaneous substitution of Gly96 toAla and Ala183 to Thr in 5-enolpyruvylshikimate-3-phos-phate ... et al. 27 62 FEBS Journal 27 8 (20 11) 27 53 27 66 ª 20 11 The Authors Journal compilation ª 20 11 FEBScatalytic base, and the 17-fold drop in kcat for theY118F mutant implicates Tyr118 as a catalytic...

Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt

... induced theappearance of an  68-kDa band in wild -type, Y18F,Y29F, Y197F and Y310F tau, this band was notapparent on western blots of lysates of Y394F tau(Fig. 2A) . The absence of this larger species ... theappearance of an  68-kDa tau species in wild -type and all of the mutant forms of tau except for YallF and Y394F tau (Fig. 3). In contrast to the results obtainedwith Fyn-SH2, wild -type tau and all of ... Densitometric analysis of GST–Fyn-SH2-bound tau, as a proportion of total tau in each celllysate, revealed that pervanadate increased Fyn-SH2–tau binding by approximately six-fold as comparedwith controls...

Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... fungal laccase fromThielavia arenaria – common structural features of asco-laccasesJuha P. Kallio1, Chiara Gasparetti 2 , Martina Andberg 2 , Harry Boer 2 , Anu Koivula 2 , Kristiina Kruus 2 ,Juha ... 628 5–6300.Crystal structure of a Thielavia arenaria laccase J. P. Kallio et al. 22 94 FEBS Journal 27 8 (20 11) 22 83 22 95 ª 20 11 The Authors Journal compilation ª 20 11 FEBS41 Zuma´rraga M, Camarero S, ... ± 2 8.3 ± 0.4 2. 0 ± 0.1 21 ± 1 2. 6 ± 0 .2 Crystal structure of a Thielavia arenaria laccase J. P. Kallio et al. 22 84 FEBS Journal 27 8 (20 11) 22 83 22 95 ª 20 11 The Authors Journal compilation ª 20 11...

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... atoms) and rjis the standard deviation of Bfactors. The normalized B factors have a zero mean and unitvariance. All atoms that satisfy Bz‡ 4 are treated as outliers and discarded. After ... 35.7 A ˚ 2 for side-chainatoms and 33.8 A ˚ 2 overall ( 324 4 atoms). For the pep-tide, B factors are slightly higher than those for importin -a: 36.9 A ˚ 2 for main-chain atoms, 40 .2 A ˚ 2 for side-chain ... importin -a nuclear import pathway, provided that CLIC4 can undergo a conforma-tional rearrangement that exposes the NLS in an extended conformation.DatabaseStructural data are available in...

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