... up-regulation of survivin expression [52]. The levels of cIAP-2 aredown-regulated by gefitinib or erlotinib in intestinalepithelial cells [53]. Furthermore, the expression of cIAP-1 and of X-linked ... family genes and the phos-phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members.However, each type of cancer has its own way of disrupting the ... signals for re-organization of the cytoskeleton, the formation of lamellipodia, mem-brane ruffling and changes in cell morphology.Accordingly, dysregulation of the EGFR contributesto the progression,...