... NADH
generation, due to amino acid biosynthesis. Much of
the generation of NADH during amino acid biosyn-
thesis takes place in the mitochondria. Because of the
block in the respiratory chain caused by the addition
of ... Fermentative lifestyle in yeasts
FEBS Journal 274 (2007) 976–989 ª 2007 The Authors Journal compilation ª 2007 FEBS 989
Fermentative lifestyle...
... triphosphate
to the 5¢-hydroxyl group of thymidine, forming dTMP. Human TK1 is
cytosolic and its activity is absent in resting cells, appears in late G
1
,
increases in S phase coinciding with the increase ... origin [14], the feedback inhibitor dTTP was
bound in the substrate pocket, similar to the binding
of dTTP to the D. melanogaster multi-substrate
deoxyribonucl...
... Mutations in
domains remote from the chemical chaperone binding
active-site domain may continue to be subject to mis-
folding, despite binding-induced stabilization of the
active-site domain, especially ... could bind to and stabilize these
folded mutant enzymes in the ER, enabling their traf-
ficking on to the lysosome (Fig. 3). These so-called
‘pharmacologic chaperones’ a...
... of the metal-binding reaction within each
of the domains. Thus, the goal is to elucidate the meta-
llation mechanisms of the individual domains, in the
hope, initially, of simplifying the interpretation ... coordination of the first
two metal ions to the a domain in independent tetra-
thiolate sites, the choice for the third incoming metal
ion would be to form a...
... is important to distinguish whether the m utations
disrupt the ice–binding interaction by c hanging the surface
properties of t he protein, or by altering the structure of the
protein.
1
H-NMR ... solve the interaction at the atomic level and
understand t he role of the threonine side chains in ice
binding. The contradiction between the higher activity
demonstrated by...
... However, in all C-domains of catalase–
peroxidases, there is a conserved arginine (Arg622 in
HalomarCPc) in t he corresponding position, indicating that
these domains lost their ability to co-ordinate ... the origin of the kingdom
Plantae among the phyla of the ancestral kingdom Protozo a
[45]. Hence, it is reasonable to suppose a common origin of
extant APXs in the anci...
... out to localize the ligand
binding sites in the leukocyte b
2
integrins. The a chains of
the CD11/CD18 integrins contain an inserted approxi-
mately 200-amino-acid intervening domain (I domain),
which ... tested in cellular
binding assays to find out possible differences in binding of
ICAM-4 and the other two ICAMs for the I domains.
Many of these mAbs displayed similar i...
... is to determine if the meaning
of one text (the entailed hypothesis denoted by
)
can be inferred from the meaning of the other text
(the entailing text or
).
In this paper, we propose a model to ... ensured the relevance of the lexical chains
by limiting the path length to three relations and
the set of WordNet relations used to create the
chains by discarding th...
... instance, the contrast in
(1) is based on the knowledge that kicking the ball
into the wrong goal implies scoring a goal for the
opposing team. In a HOU approach, the contrast
in this example ... lead to a cor-
rect accentuation pattern if contrastive information
is not taken into account, as shown in example (1). t
(1) a Ill the 16th minute, the Ajax player Kl...
... regulated by GTP binding and hydrolysis [4–7].
Toc34
GDP
interacts with the second G-protein in the
Toc complex, Toc159, and simultaneously transfers the
preprotein to Toc159. Toc159 action facilitates ... 1A,
lanes 4–6). The import of QORH into the inner enve-
lope of chloroplasts was shown to depend on targeting
information present in the C-terminus of the pre-
protei...