Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
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The localization of FGFR3 mutations causing
thanatophoric dysplasia type I differentially affects
phosphorylation, processing and ubiquitylation
of the receptor
Jacky Bonaventure
1,2
, Linda Gibbs
2
, ... 3 (FGFR3) mutations
have been ascribed to skeletal dysplasias of variable severity including the
lethal neonatal thanatophoric dysplasia...
... recognition could not be blocked by
pre-incubation with PRiMA antigen. These results
clearly indicate the specificity of the PRiMA antibody
in recognizing the cytoplasmic domain of PRiMA I.
According ... regulation of PRiMA is down-regulated during
myogenic differentiation and under the influence of
innervation [9]. In line with the transcriptional expres-
sion of PRiMA,...
... Asn334, is
conserved in all subunit types (Hc1 and Hc2) with the
exception of PmaHc1. An insertion of nine amino
acids in PamHc2 starting at amino acid 435 is unique
to subunit types 2. On the amino ... the
hexamerins of the dicondylian insects (Fig. 2). Hemo-
cyanins and hexamerins share many characteristics in
Fig. 3. Occurrence of both hemocyanin subunit types in Hexapo...
... specifically increase the
activity of aB-crystallin against DTT-induced precipi-
tation of insulin at intermediate and high concentra-
tions, and it also increased the activity of aB-crystallin
in preventing ... against the DTT-induced aggregation and precipi-
tation of insulin.
A
C
B
Fig. 2. aB-crystallin protects against the
DTT-induced aggregation of insulin, and t...
... processes of its folding and unfolding is a prerequisite for under-
standing the epigenetic regulation in cell differentiation. Although the
shape of the fibre and its dimensions and mass per unit length ... product of MNase
digestion of all the fractions, including S, is mononu-
cleosome size DNA and the ten nucleotide periodicity
is preserved in the DNase I dige...
... reduction in the binding affinity was
observed in the case of binding of the M.HhaI with
the X
+
CG ⁄ CGM duplex containing the (+)-cis-B[a]P-
N
2
-dG adduct on the 5¢-side of the target dC residue.
The ... contacts
with the catalytic loop of the enzyme from the DNA
minor-groove side. The contacts of the amino-acid
A
B
CD
Fig. 3. Equilibrium competitive bind...
... RNases’
EIE
max
values and their positive net charges, but also
with their ability to destabilize a membrane.
We then considered the possibility of a correlation
between the cytotoxic action of the investigated dimeric
RNases ... prototype, has interested and intrigued
investigators. Their ribonucleolytic activity is essential for their cytotoxic
action, and their target RNA i...
... degradation and repair in
ageing and oxidative stress
B. Friguet
Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement,
Universite
´
Denis Diderot – Paris 7, Paris, France.
E-mail: bfriguet@paris7.jussieu.fr
Cellular ... decreased elimination of
oxidized protein. Since the proteasome is in charge of protein turn-
over and removal of oxidized protein, its fate during...
... density of RTA R213D in the vicinity of residue 213. The backbone and sidechains of the R213D substitution are shown as stereo
images in thick ball and stick and the position of the Arg213 side-chain ... substitution are shown as stereo
images in thick ball and stick and the position of the Asn122 side-chain of the wild -type enzyme is overlayed and sh...
... [3], and Chlamys islandica [4,5].
These authors noticed the striking similarity between the
bivalve lysozyme and another protein, the so-called desta-
bilase identified in the medicinal leech Hirudo ... database of the National Center for
Biotechnology Information (NCBI) shows significant
sequence similarities with the destabilase of the medicinal
leech H. medicinalis [7],...