Tài liệu Báo cáo khoa học: Attenuation of cardiac mitochondr

Tài liệu Báo cáo khoa học: Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice ppt

... 1 after deducting basal and background values. Sepsis resulted in a signiﬁcant increase in the transcription of the mRNA encoding iNOS in heart of iNOS + ⁄ + mice. The expression of iNOS mRNA was ... was lower in iNOS – ⁄ – than in iNOS + ⁄ + mice (Fig. 3A). The mitochondrial level of GSH decreased and that of GSSG increased in hearts from iNOS + ⁄ + mice after C...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... occur in the brain include selective loss of dopaminergic neurons in substantia nigra pars compacta and appearance of Lewy bodies consisting of aggregated protein, mainly a-synuclein, in Keywords amyloid; ... results obtained when a-synuclein was incubated in the absence of MPTP. When a-synuclein was incubated alone in the presence of dopamine, it led to inhibition of ﬁb...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx

... inhibitors, binding revers- ibly into the active site of the enzyme. Cystatins, including human cystatin C, are general inhibitors of cysteine proteases. For cathepsin B, their K i value is in nanomolar ... nm, depicting a strong interaction between 2A2 mAb and cathepsin B. Determination of the 2A2 mAb binding site on cathepsin B The binding site of 2A2 mAb on cathepsin B was determ...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Phosphorylation of hormone-sensitive lipase by protein kinase A in vitro promotes an increase in its hydrophobic surface area ppt

... creating high levels of background fluorescence, we investigated the possibility of using lower amounts of ATP for the phosphorylation of HSL. Using radiolabelled ATP, we showed that, by using ... a first attempt to investigate whether the increase in hydrophobic surface area is reflected by increased binding of phosphorylated HSL to lipid surfaces, we investigated the interactio...

Ngày tải lên : 18/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Characterization of 1H NMR detectable mobile lipids in cells from human adenocarcinomas doc

... 1343 where the relevant increase of m 2 produces the relevant intensity changes of ML ⁄ TG signals. In principle, such an increase can be due to both a decrease in c 1 and an increase in p 1 after growth ... dimension. A sine function was applied in both dimensions of the time domain before Fourier transformation. Integration of 1D and 2D signals was performed using 1D winnmr...

Ngày tải lên : 18/02/2014, 13:20

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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... of uPA are causally involved in tumor progression, the understanding of these underly- ing intracellular events is of importance. In the present study, we explored the signaling pathway linking ... signaling, we made use of speciﬁc inhibitors of various kin- ases potentially involved in this signaling. Figure 4C A B C Fig. 4. Effect of CytD and several kinase inhibitors on...

Ngày tải lên : 19/02/2014, 05:20

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Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt

... formation of carbonyl residues in proteins. The enhanced oxidation of proteins observed in httEx1-polyQ-expressing cells was not found to correlate with an increased intracellular level of iron. Interestingly, ... sub- stitution of the unique cysteine residue of Hsp27 by an alanine residue, and is unable to protect against cell death induced by different agents, including...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Selection of stably folded proteins by phage-display with proteolysis docx

... N-terminal domains (N1, N2) of the minor coat protein (g3p) are responsible for binding and infection in E. coli.Thus, incorporation of a library of target proteins between the N-terminal domain ... Protein design by binary patterning of polar and non- polar amino acids. Science 262, 1680–1685. 8. Michnick, S.W. (2001) Exploring protein interactions by interaction-induced fold...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Stimulation of poly(A) synthesis by Escherichia coli poly(A)polymerase I is correlated with Hfq binding to poly(A) tails ppt

... which, in this case, has an inhibitory effect on binding of poly(A) by PNPase. In contrast, an interaction between Hfq and PNPase would be expected to inhibit both initiation and elongation of ... was proposed to be bound by Hfq at an internal site framed by two stable hairpins [13]. This suggested that Hfq binding is independent of the location of the AU rich region in...

Ngày tải lên : 19/02/2014, 16:20

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Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... and apply phonological consistency in GPCs, including the roles of PCs in PSCs in Chinese, plays an instrumental role in learners’ competence in reading Chinese. Phono- logical consistency is ... remember the writing of Jhuyin symbols after the winter break. Hence, after the evaluation, we strengthened the feedback by adding Jhuyin information. In Fig- ure 2, the Jhuyi...

Ngày tải lên : 19/02/2014, 19:20

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