Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
... phosphorylated ERK, p38 and JNK (p-ERK,p -p38 and p -JNK) and total ERK, p38 and JNK (tERK, tp38 and tJNK). (B) The ratio of phosphorylated to total ERK (p44 ⁄ 42), p38 and JNK at each time point. The data ... JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves Aiguo Shen1,*, Junling Yang2,*, Yangyang Gu3, Dan Zhou4, Linlin Sun2, Yongwei Qin2,Jianping Chen2, Ping ... important role of SAPK ⁄ JNK in mediating LPS-induced ICAM-1 expression in SCs. JNK phosphorylates c-Jun and ATF-2 and increasestheir ability to activate transcription, leading to c-juninduction...
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Tài liệu Báo cáo khoa học: "Logistic Online Learning Methods and Their Application to Incremental Dependency Parsing" doc
... correct linkwith an incorrect label, and 1 for an incorrect link.Since the history-based feature set used in theparsing algorithm makes it impossible to use inde-pendence to factorize the scoring ... hasspurred a growing interest of related research in themachine learning community, which in turn has led to improved results in a wide range of applications in NLP, including sequence labeling (Lafferty ... at the origin seems to pose no problem in practice.Costs are incorporated into the model by as-sociating them to the prior variances. We triedtwo variants of variance scaling. In the first...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... leading to autophosphoryla-tion of tyrosine residues on the cytoplasmic domain of thereceptor, thereby creating docking sites for adaptor pro-teins, such as Shc and G rb2. The latter protein ... indu ce expression of genes involved in cell cycle progression include Elk1, c-fos,c-Jun and c-myc [9,15]. The duration of ERK activation (transient or sustained) determines the repertoire of ... of iEGFR causes it to recycle back to the cell su rface. In addition it cau ses a decreased EGF bin ding affinity and tyrosinekinase activity of the r eceptor. Also shown are the stimulators and inhibitors(depictedinred)usedinthisstudy.EGFwasusedtoactivatethe...
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Tài liệu Báo cáo khoa học: Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis pptx
... inactivation of matrix proteins and various protease inhibitors, including antithrombin, C1inhibitor, heparin cofactor II, and a2-antiplasmin [10].Previous reports have described the interactions of TFPI ... the interactions between TFPI and serine proteinases derived from the secretory granules of in ammatory cells. To investigate the functional role of TFPI in inflam-mation, we examined the interactions ... smeared bands (bands 1 and 2) with molecular masses of 20–30 kDa observed onSDS ⁄ PAGE. Subsequently, the level of the approxi-mately 15-kDa band increased, and TFPI (43 kDa) aswell as bands 1 and...
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Tài liệu Báo cáo khoa học: Globin gene family evolution and functional diversification in annelids ppt
... evolutionaryelaboration of the HBL-Hb structure simultaneouslyinvolved the possibility for globins and linkers (proteinsinvolved in the structure of HBL-Hb) to interact and to bind to dimers or other ... 2007)doi:10.1111/j.1742-4658.2007.05799.xGlobins are the most common type of oxygen-binding protein in annelids. In this paper, we show that circulating intracellular globin (Alvinella pom-pejana and Glycera dibranchiata), noncirculating ... alignment of annelid DHP,extracellular and intracellular globins (circula-ting and noncirculating) amino-acidsequences. Intracellular globin sequencesare shaded. Positions of intron 1 (B12.2) and 2...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc
... detailed e xamination of the stepsinvolved in subunit d issociation and reassociation willcontribute to a better understanding of the dimerizationprocess per se and the role of interprotomeric contacts ... preparation of apo-CcStP and thecharacterization thereof in respect to structural properties and kinetic stability. The process of reconstitution with PLPhas been analyzed using CcStP and four ... in dimer formation and a ppearance of thermostabilization byphosphate has been examined. The role of the cofactor5¢-phosphate group in the induction of stability and stabil-ization of the CcStP...
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Tài liệu Báo cáo khoa học: Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebrafish (Danio rerio) doc
... functional importance of invariant aminoacids of the corresponding alpha-helical C-terminalglobular domain of human PrPCcan be demonstratedwith Pro102, Ala117, and Gly131 variants of humanPrPC. ... corresponding to gb|BM071383| and including the putative initiatormethionine was ordered from the Resource for theGerman Genome Project (RZPD), Berlin, Germany,double strands were sequenced, and ... com-pared to human PrPCsequences, i.e. 47 residuesinstead of 15 residues, including strand S2, betweenhelices H1 and H2, and 84 residues instead of 10 resi-dues between helices H2 and H3 (Fig....
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Tài liệu Báo cáo khoa học: FGF-2, IL-1b and TGF-b regulate fibroblast expression of S100A8 doc
... the S100 family of Ca2+-binding proteins and are now accepted as markers of in ammation. They areexpressed by keratinocytes and in ammatory cells in human ⁄ murine wounds and by appropriately ... isimportant in cell proliferation, differentiation, embryo-genesis and synthesis of in ammatory cytokines [43,52] and is essential for S100A8 induction in macrophages[27]. Inhibitors of the MEK and ... macrophages, endothelial cells, epithelial cells and keratinocytes in vitro. In this study, regulation and expression of S100A8 and S100A9 were examined in fibroblasts. Endotoxin (LPS), interferon c(IFNc),...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... chain intoN-terminal and C-terminal centers during refolding[21]. Since then, many scientists have been interested in demonstrating this concept by using N-terminal and C-terminal fragments of ... located in the C-terminal loop of SNase plays an important role in protein stability and conforma-tional integrity. During protein unfolding ⁄ refolding,the addition of 2.5 protons (both E75 and ... 2005 FEBSinvestigated. Two point-mutated proteins, with a singlebase substitution of alanine for tryptophan (W140A) and alanine for lysine (K133A), and two truncatedfragment proteins, with...
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Tài liệu Báo cáo khoa học: "Word representations: A simple and general method for semi-supervised learning" doc
... and vice-versa. We apply clus-tering and distributed representations to NER and chunking, which allows us to compare oursemi-supervised models to those of Ando and Zhang (2005) and Suzuki and ... Collobert and Weston (2008) embeddings, and HLBL(Mnih & Hinton, 2009) embeddings of words on both NER and chunking.We use near state -of- the-art supervisedbaselines, and find that each of the ... embedding is transformedinto a probability by exponentiating and thennormalizing. Mnih and Hinton (2009) speed upmodel evaluation during training and testing byusing a hierarchy to exponentially...
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