Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modiﬁcations ppt

... 2008)doi:10.1111/j.1742-4658.2008.06347.xStrategies for the chemical construction of synthetic proteins with preciselypositioned post-translational modifications or their mimics offer a powerfulmethod for dissecting the complexity of functional ... consequence of the lack of direct genetic control of their biosynthesis, natural PTMs vary in site and level of incorporation, leading to mixtures of modified pro-teins that may differ in function. ... ARTICLE Chemical approaches to mapping the function of post-translational modifications David P. Gamblin, Sander I. van Kasteren, Justin M. Chalker and Benjamin G. DavisChemistry Research Laboratory,...

Tài liệu Báo cáo khoa học: "Harnessing NLP Techniques in the Processes of Multilingual Content Management" pptx

... Future Work The abundance of knowledge allows us to widen the application of NLP tools, developed in a research environment. The tailor made voting system maximizes the use of the different ... platform. The platform enriches the content of these websites with revealing details and reduces the manual work of classification editors by automatically categorising content. The platform ... phase. The language processing tools are integrated in a language processing chain (LPC), so that the output of a given NLP tool is used as an input for the next tool in the chain. The baseline...

Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf

... denaturant). The problem isthat there is another limitation to library approaches: onemust be able to identify the functional proteins at the end of the experiment.Identiﬁcation of selectantsThere ... the absence of polar sidechains (oil-droplet behavior).Further libraries have been created to explore these issues,and we will also expand the scope of these studies to largerportions of the ... each of the 1065variantswouldweighinat1039tonnes; approximately the mass of the Milky Way galaxy). We currently lack the theoreticalframework to quantitatively predict the effects of even...

Tài liệu Báo cáo khoa học: Computational approaches to understand a-conotoxin interactions at neuronal nicotinic receptors doc

... [4,5]).Most of the work has been performed on the musclesubtype, thanks to the large amount of the receptorobtained from the electric organ of the Torpedo marmorataray and availability of selective ... increasing use of computational tools in the ﬁeld of nicotinic receptors has led to the publication of severalmodels of ligand–receptor interactions. These models are allbased on the crystal structure ... (–), the N-terminus of the b6(–)andb1 (–) strands and the C-terminus of the b2 (–)strand. In addition to these observations, several lines of experimental evidence reinforce these cavities as the...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... of the CD95 from inside the hepatocyte to the plasma mem-brane [39], which depends on a ROS-mediated tyrosinephosphorylation of the epidermal growth factor(EGF)-receptor, the association of ... trafﬁcking of the CD95 to the plasma membrane surface, and deathinducing signaling complex formation, leading to the execution of apoptosis in this case [38]. Although inef-fective to induce apoptosis ... rat hepa-toma cells to pro-apoptotic signaling by the protea-some inhibitor MG-132 [40].These and other studies on hyperosmotically shrun-ken cells support the view that the apoptotic volumedecrease,...

Tài liệu Báo cáo khoa học: An intermediate step in the evolution of ATPases – a hybrid F0–V0 rotor in a bacterial Na+ F1F0 ATP synthase pdf

... apair of coupled motors, a chemically driven motor (F1)and a membrane-embedded, ion gradient-driven motor(F0) [3]. The membrane-embedded motor comprises astator and a rotor. The stator is ... that the c ringscontain both types of c subunits. The stoichiometry for c2⁄ c3: c1was9 : 1. Furthermore, this stoichiometry was independent of the carbonsource of the growth medium. These ... representation of Fig. 2A. Bycomparison with the 3D structure of the I. tartaricusc ring [24], the black rings represent the view from the cytoplasm (open rings in AFM) and the red ones the view from the...

Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx

... has to approach the ste-roidal substrate for both abstraction of a hydrogenatom and insertion of the hydroxyl group. Thus,C17 must be able to come close to the heme iron,presumably due to the ... purifying them and determining the substrates from which they arose by the action of P450scc, as well as the products that they gave rise to. This revealed both the major and minor pathways for the ... correlations in the COSY spectrum to four protons, and analysis of HSQC indicates that these protons belong to two meth-ylene groups (Fig. 6C). The complete spin systemrevealed by the TOCSY spectrum...

Tài liệu Báo cáo khoa học: From heart to mind The urotensin II system and its evolving neurophysiological role ppt

... conﬁned to certain motor nuclei of the centralnervous system (CNS). From the very beginning, theseﬁndings pointed to a possible neuromodulatory rolefor UII. The aim of this review is to provide ... Phylogeneticanalysis of the receptor’s primary sequence shows stri-king similarities to the somatostatin receptor family,most notably in the transmembrane domains. The pharmacological relatedness of somatostatin ... projection areas of the LDT PPT complex leading to the hypothesis that the binding sites might represent presynaptic neuro-nal terminals. Because cholinergic neurons of the LDT PPT are functionally...

Tài liệu Báo cáo khoa học: "An Experiment in Evaluating the Quality of Translations" pdf

... original. For the purposes of this experiment, the question of the fidelity of a translation was converted into the complementary question of whether the original could be found to con- tain ... was to be judged in terms of the “informativeness” of the original relative to the translation. In this way, the translation is being evaluated—not the original—since the judg- ments of the ... Russian they might have to divine the meaning of the translations. The rankings of the translations by the average rat- ings on the informativeness scale are almost precisely complementary to the...

Tài liệu Báo cáo khoa học: "An API for Measuring the Relatedness of Words in Wikipedia" docx

... applications,e.g. the MediaWiki software5, integrated within aLinux, Apache, MySQL and PHP (LAMP) softwarebundle. The architecture of the API consists of the following modules:1. RDBMS: at the lowest ... ency-clopedia entries to the MediaWiki software (whichin turn queries the database) and efﬁciently parsing the text responses into structured objects.5 Using the API The API provides factory classes ... access the encyclopedia pageobjects and compute the relatedness scores. The information ﬂow of the API is summarized by the sequence diagram in Figure 2. The higher in-put/output layer the user...

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