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Tài liệu Children''''''''s Health and the Environment Children''''''''s Health and the Environment doc

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... COS7 and 293Tcells and did not vary like BTK–SYK; therefore, the differences in the PH–TH domains remain the decisivefactor for this variation. The B-cell adapter protein BLNK (SLP-65) and itsT-cell ... posi-tioned in the connecting loops. Approximately one-third of all mutations in the BTK gene are missense and some of these reduce the stability of the protein.This is exemplified by mutations in the ... also identify individualswith mild disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humanshas...
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Tài liệu Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment - Subgroup Report on the Lowermoor Water Pollution Incident pdf

Tài liệu Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment - Subgroup Report on the Lowermoor Water Pollution Incident pdf

... for Environmental Health (MOEH) (DHSS Circular HRC (74)13). 5.22 At the Cornwall and Isles of Scilly Health Authority, the main health professionals involved in handling the consequences to health ... August 1988 and circulated by the Health Authority to local doctors and residents during the last week in August (seeAppendix 14 for a copy of the letter). At the same time, the Health Authority ... practice at the time of the incident. Half of these had received water from the Lowermoor reservoir and half from the De Lankreservoir. The practice saw no difference in the health of the two populations...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf

Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf

... 5¢-CCTGCCGAGCTCCTATTACACAACGCCACCAACCATCAG-3¢. The PCR solution was prepared in the buffer suppliedwith the enzyme, and contained Aba, Abb and Abcat40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 ... as with the studies by Lee et al. [21] and Subramanian and Shree[42], there was no rigorous assessment of the purity of the product or the correctness of the sequence. In con-trast, the purification ... chromatography and subsequent throm-bin cleavage [41]. The use of thrombin significantlyincreases the cost of the purification, and the require-ment for HPLC increases the length and complexity ofthe...
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Tài liệu Báo cáo khoa học: Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity ppt

Tài liệu Báo cáo khoa học: Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity ppt

... as children and patients with cysticfibrosis, burn wounds or leukemia [18]. The virulencetoxin ExoS from P. aeruginosa is first secreted and then translocated from the bacteria into the eukaryoticcell ... GST-ExoS(D427A),GST-ExoS(L428A) and GST-ExoS(LD426–427AA)(Table 1). All GST-ExoS derivatives were expressed and purified, and were then employed in protein pull-down experiments (Fig. 1). HeLa cells were harvested and the ... at positions 424 and 427 of the ExoS binding site for 14-3-3. These substitutions didnot alter the ExoS)14-3-3 interaction under the condi-tions tested (Fig. 1, lanes 7, 13 and 16).Although...
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Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P3 docx

Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P3 docx

... Once you assert the statement's elements into the datasource in this way, the datasource contains the triple. The truth value parameter in the last slot indicates that the given node is ... allDataSources is an nsISimpleEnumerator returned by the GetDataSources method on the composite datasource. datasource1 is removed from the composite, and then the remaining datasources are cycled through. ... through XPCOM. The examples in this section use JavaScript and XPConnect to access the components for simplicity, but you can also use these interfaces with C++, as they are often in the actual...
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Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P4 pptx

Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P4 pptx

... in the datasource The RDF/XML data that was in the string is a part of the datasource and ready for use (just like any other RDF data in a datasource). The uri acts as a base reference for the ... event handling. The interfaces are totally separate, but behind the scenes, they work together with the incoming data. Example 10-10 shows how a series of events is created in an object and then ... example, the Init and Refresh methods control the datasource on the server. In addition to these methods, you can call the Flush method to flush the data that's been changed and reload,...
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Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P5 pdf

Tài liệu Creating Applications with Mozilla-Chapter 10. RDF, RDF Tools, and the Content Model-P5 pdf

... such as the browser) by this package. This section contains only one RDF:li the modern theme. The next section gives more information on the theme, such as the author, the theme name, and a ... in the sequence. Next, it ensures that you actually want to add the item to the RDF file and flushes it out if not. It then recalls the onload function to update the template display. These ... can see, the manifest is divided up into sections. After the preamble, where the XML processing instruction and the namespace declarations are made, an RDF sequence lists all the themes defined...
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Tài liệu Indoor air pollution in developing countries: a major environmental and public health challenge doc

Tài liệu Indoor air pollution in developing countries: a major environmental and public health challenge doc

... forenvironmental tobacco smoke and ambient pollu-tion. With these outcomes, the major weakness in the evidence relates to the quantification of the expo-sure-response relationship. For other health ... well-conducted rando-mized controlled studies on the health impact ofreducing exposure would markedly strengthen the evidence, and should be feasible at the householdlevel. For conditions where the evidence ... of the World Health Organization, 2000, 78 (9)Special Theme – Environment and Health 53. Malik SK. Exposure to domestic cooking fuels and chronicbronchitis.Indian Journal of Chest Diseases and...
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Tài liệu A junk‐free childhood: Responsible standards for marketing foods and beverages to children doc

Tài liệu A junk‐free childhood: Responsible standards for marketing foods and beverages to children doc

... YesFurthergapsincompany‐ledself‐regulationThissectionprovidessomeexamplesofadditionalconcernsraisedduringthisinvestigation. The examplespicturedaretakenfromwebsitesactive and availableduring the periodJanuary‐June2011.Company‐ownedwebsitesWhilemostcompaniesacknowledge the needtocontroladvertisingtochildrenusingpaid‐foradvertisingonthird‐partysites,companiesdonotusuallyincludetheirownweb‐sites,whichtheyseeaseditorialratherthanadvertising.Althoughsomegovernment‐approvedcodes(e.g. the UKCAPCode)includecompany‐ownedsites,mostindustry‐wideadvertisingregulationsinEuropeancountriesdonot, and industry‐ledpledgesgenerallydonotorareambiguousaboutwhattheyconsider‘advertising’ontheirownwebsites.Manycompaniesusetheirownsitestoattractchildrenwithgames,puzzles,clubs and downloadablegifts,orofferbrandedproductswhichchildrenmaypestertheirparentstobuy.ExamplesbelowshowNesquikchildren’sgamesonacompany‐ownedsite and anexampleofM&Mspromotions(someareasof the siteaskif the viewer‘sageisabove12years).10SocialnetworkingsitesThereisalsoa‘grey’areaconcerning the usebycompaniesofthird‐partysocialnetworkingsitessuchasFacebooktopromotechild‐attractiveactivitieswithfood‐relatedbranding.Anexampleof the useofFacebookisshownbelow:11GeneralisedbrandingCompaniesdonotusuallyincludeintheirself‐regulationanycontrolson the brandingofnon‐foodproductswithfood‐relatedbrandidentities.Althoughcarryingnospecificmarketingmessage, the associativeeffectcanbeapowerfulmarketingtool. The examplebelowshowsaproductlikelytoappealtochildrenbrandedwithanimagestronglyassociatedwithsweetenedbreakfastcereal(Kellogg’sFrosties) and licensedbyownerforuseon the product.12Schools and otherchildren’ssettingsCompaniesmayallowthemselvestomarketinschools and otherplaceswherechildrengather.Thiscantake the formofbrandedgoods and equipmentor the activepromotionofsamples and brandedgiftsinschoolsettings.IndirectuseofschoolssettingsmaybefoundwhenTVadvertisementsuseschoolsaslocationsforfilmingtheiradvertising. The examplebelowshowsaplayareaforchildrensponsoredbyachocolatecompanyownedbyNestléinGenevaairport(which the companyhassinceacknowledgediscountertoNestlépolicies) and the useofclassroomsettingsforTVadvertisinglocations(notinEurope).13Characterlicensing and brandequitycharactersAlthoughsomecompanieshaveagreedtoreduce the useoflicensedcharacters(e.g.filmtie‐inssuchasShrek and ToyStory)otherscontinuetousesuchmarketingdevices.Examplesbelowshowlicensedcharactersfromfilms(Rio,Thor,KungFuPanda)usedtopromoteproductshighinsugarsorfats.NotethatKungFuPandaisbeingusedbyMcDonald’s,acompanythathasnotjoined the EUpledgescheme.14Inaddition,mostcompaniesstillpermitthemselvestousecharacterswhichtheyown and havedevelopedwiththeirbrands(knownasbrand‐equitycharacters),suchasQuiky the bunny(Nesquik) and Tony the Tiger(Frosties).OthersincludeUnileverWalls‘Max the lion’(seepicturebelow).15Productdesign and packagingSelf‐regulationgenerallydoesnotincludepackagingorproductdesign and thesecanbepowerfulmarketingtoolstoattractpurchases. The examplebelowshowsaproductshaped,flavoured and texturedtoappealtochildreninaboxwithatie‐ingamelaunchedbyKellogg’sonFacebook and featuring the KraveKrusader(whomustovercomechallenges and obstaclestoreachchocolate).26ShopdisplaysRetaildisplaysarerarelyincludedincompany‐ledself‐regulation.Aisle‐enddisplays and check‐outdisplaysarepremiumsites and canbeamajorinfluenceonspontaneouspurchases and, especiallyin the caseofcheck‐outdisplays, the purchaseofanitemforceduponaparentbychildrentaking the productintheirhandswhilewaitinginline.Child‐to‐childmarketingPeerrecommendationisastrongmotivatoramongchildren and adolescents.Marketersareusinganumberofmethodsforencouragingchild‐to‐childmarketing,includingpaymentstoyoungpeopletomakerecommendations and encouragementofchildrentomaketheirown26Seehttp://www.marketingweek.co.uk/sectors/food and drink/kellogg%E2%80%99s‐moves‐into‐gaming/3026796.article16promotionalmaterialsfordistribution,e.g.onsocialmedianetworks.Self‐regulationgenerallydoesnotcoverchild‐to‐childmarketing.Examplesbelowshowbrand‐owned,child‐attractivewebsitesaskingchildrentosendemailmessagestotheirfriendsabout the website.NotethatHaribohasnotjoined the EUpledgescheme.NewtechnologyMethodsformarketingtochildrenarerapidlyevolving, and manyaredesignedtoby‐passparentsorenhancechild‐to‐childmarketing.In2007KFC’sadvertisingagencyengineeredaTVcommercialcontaininghigh‐pitchednoiseswhichonlyyoungpeoplearelikelytohear–Ajunk‐freechildhood:Responsiblestandardsformarketingfoods and beveragestochildrenAbriefingpaperfrom The StanMarkProjectof the InternationalAssociationfor the StudyofObesityPreparedbyTimLobstein,TriinParn and AngeAikenheadStanMark ... YesFurthergapsincompany‐ledself‐regulationThissectionprovidessomeexamplesofadditionalconcernsraisedduringthisinvestigation. The examplespicturedaretakenfromwebsitesactive and availableduring the periodJanuary‐June2011.Company‐ownedwebsitesWhilemostcompaniesacknowledge the needtocontroladvertisingtochildrenusingpaid‐foradvertisingonthird‐partysites,companiesdonotusuallyincludetheirownweb‐sites,whichtheyseeaseditorialratherthanadvertising.Althoughsomegovernment‐approvedcodes(e.g. the UKCAPCode)includecompany‐ownedsites,mostindustry‐wideadvertisingregulationsinEuropeancountriesdonot, and industry‐ledpledgesgenerallydonotorareambiguousaboutwhattheyconsider‘advertising’ontheirownwebsites.Manycompaniesusetheirownsitestoattractchildrenwithgames,puzzles,clubs and downloadablegifts,orofferbrandedproductswhichchildrenmaypestertheirparentstobuy.ExamplesbelowshowNesquikchildren’sgamesonacompany‐ownedsite and anexampleofM&Mspromotions(someareasof the siteaskif the viewer‘sageisabove12years).10SocialnetworkingsitesThereisalsoa‘grey’areaconcerning the usebycompaniesofthird‐partysocialnetworkingsitessuchasFacebooktopromotechild‐attractiveactivitieswithfood‐relatedbranding.Anexampleof the useofFacebookisshownbelow:11GeneralisedbrandingCompaniesdonotusuallyincludeintheirself‐regulationanycontrolson the brandingofnon‐foodproductswithfood‐relatedbrandidentities.Althoughcarryingnospecificmarketingmessage, the associativeeffectcanbeapowerfulmarketingtool. The examplebelowshowsaproductlikelytoappealtochildrenbrandedwithanimagestronglyassociatedwithsweetenedbreakfastcereal(Kellogg’sFrosties) and licensedbyownerforuseon the product.12Schools and otherchildren’ssettingsCompaniesmayallowthemselvestomarketinschools and otherplaceswherechildrengather.Thiscantake the formofbrandedgoods and equipmentor the activepromotionofsamples and brandedgiftsinschoolsettings.IndirectuseofschoolssettingsmaybefoundwhenTVadvertisementsuseschoolsaslocationsforfilmingtheiradvertising. The examplebelowshowsaplayareaforchildrensponsoredbyachocolatecompanyownedbyNestléinGenevaairport(which the companyhassinceacknowledgediscountertoNestlépolicies) and the useofclassroomsettingsforTVadvertisinglocations(notinEurope).13Characterlicensing and brandequitycharactersAlthoughsomecompanieshaveagreedtoreduce the useoflicensedcharacters(e.g.filmtie‐inssuchasShrek and ToyStory)otherscontinuetousesuchmarketingdevices.Examplesbelowshowlicensedcharactersfromfilms(Rio,Thor,KungFuPanda)usedtopromoteproductshighinsugarsorfats.NotethatKungFuPandaisbeingusedbyMcDonald’s,acompanythathasnotjoined the EUpledgescheme.14Inaddition,mostcompaniesstillpermitthemselvestousecharacterswhichtheyown and havedevelopedwiththeirbrands(knownasbrand‐equitycharacters),suchasQuiky the bunny(Nesquik) and Tony the Tiger(Frosties).OthersincludeUnileverWalls‘Max the lion’(seepicturebelow).15Productdesign and packagingSelf‐regulationgenerallydoesnotincludepackagingorproductdesign and thesecanbepowerfulmarketingtoolstoattractpurchases. The examplebelowshowsaproductshaped,flavoured and texturedtoappealtochildreninaboxwithatie‐ingamelaunchedbyKellogg’sonFacebook and featuring the KraveKrusader(whomustovercomechallenges and obstaclestoreachchocolate).26ShopdisplaysRetaildisplaysarerarelyincludedincompany‐ledself‐regulation.Aisle‐enddisplays and check‐outdisplaysarepremiumsites and canbeamajorinfluenceonspontaneouspurchases and, especiallyin the caseofcheck‐outdisplays, the purchaseofanitemforceduponaparentbychildrentaking the productintheirhandswhilewaitinginline.Child‐to‐childmarketingPeerrecommendationisastrongmotivatoramongchildren and adolescents.Marketersareusinganumberofmethodsforencouragingchild‐to‐childmarketing,includingpaymentstoyoungpeopletomakerecommendations and encouragementofchildrentomaketheirown26Seehttp://www.marketingweek.co.uk/sectors/food and drink/kellogg%E2%80%99s‐moves‐into‐gaming/3026796.article16promotionalmaterialsfordistribution,e.g.onsocialmedianetworks.Self‐regulationgenerallydoesnotcoverchild‐to‐childmarketing.Examplesbelowshowbrand‐owned,child‐attractivewebsitesaskingchildrentosendemailmessagestotheirfriendsabout the website.NotethatHaribohasnotjoined the EUpledgescheme.NewtechnologyMethodsformarketingtochildrenarerapidlyevolving, and manyaredesignedtoby‐passparentsorenhancechild‐to‐childmarketing.In2007KFC’sadvertisingagencyengineeredaTVcommercialcontaininghigh‐pitchednoiseswhichonlyyoungpeoplearelikelytohear–Ajunk‐freechildhood:Responsiblestandardsformarketingfoods and beveragestochildrenAbriefingpaperfrom The StanMarkProjectof the InternationalAssociationfor the StudyofObesityPreparedbyTimLobstein,TriinParn and AngeAikenheadStanMark ...  The marketingoffoods and non‐alcoholicbeverageswithahighcontentoffat,sugarorsaltreacheschildrenthroughout the world.Effortsmustbemadetoensurethatchildreneverywhereareprotectedagainst the impactofsuchmarketing and given the opportunitytogrow and developinanenablingfood environment —onethatfosters and encourageshealthydietarychoices and promotes the maintenanceofhealthyweight.DrAlaAlwan,AssistantDirectorGeneral,World Health Organization17 and followedthisupwithawebsiteofferingfreemealvoucherstothosewhocanidentify the pointin the advertisementwhen the noiseoccurred.27Morerecently,MicrosoftannouncedtechnologytoallowX‐Boxplayerstousevoicecontrolsduringgamingwhichwouldforwardadvertisingmessagestotheirfriend’sphoneswhenevermarketingpromotionswerepresentin the game.2827EBlasshttp://www.engadget.com/2007/04/11/kfc‐ad‐agency‐strikes‐again‐with‐mosquito‐tone‐commercial/28TVega,NewYorkTimes20June2011.Seehttp://www.nytimes.com/2011/06/21/business/media/21xbox.html?_r=2&ref=media18ProposedstandardsAsnotedearlier, the objectiveofuniversalstandardsistoinstituteruleswhichachievemaximumprotectionwhileremainingpractical and economicalinapplication.Althoughitcouldbeproposedthatchildrenshouldnotbeexposedtoanymarketing, the presentdocumenttakesa‘risk‐based’approachtoreducingexposureto the marketingoffood and beverageproductswhoseregularconsumptionisliabletoincrease the riskofnon‐communicablediseases.Furthermore,itisimportanttoidentifyexamplesofhighstandardsforcross‐bordermarketingwhichhavebeenproposedasaresultofconsensus‐buildingbyreputableagencies,thusindicatingthatsuchstandardsarefeasible,practical and economical.Inthissectionweproposestandardsbasedonaresponsibleapproachtomarketingon the understandingthatchildrenshouldnotbesubjectedtoinducementstoconsumeproductswhich,ifconsumedroutinely,arelikelytobedetrimentaltotheir health. Whereavailableweshowexamplesof the useofsimilarstandardsinothersectors.Standard1:Specifying the foods and beveragesIssue: The promotionofsomefoods and beveragescanunderminechildren’sdietary health. Proposal:Riskreductionmeanspromotingonlythosefood and beverageproductswhichconformtonationaldietaryguidelines and internationalstandardssupporting the WHOGlobalStrategyonDiet,PhysicalActivity and Health 29.Ahighstandard:Food and beveragesshouldbecategorisedaccordingtoavalidatednutrientprofilingsystem.Examplesmayinclude the UKOfcommodelusedtoregulateadvertisingontelevision,30 the NordicKeyholefoodcategorisationmodel,31or the proposalsfrom the USInteragencyWorkingGroup32.Standard2:AgegroupsIssue:Somemarketingworksbelowconsciouscontrol.Evenwhenchildren and adolescentsareawareofmarketing,theymaybetrusting and uncriticalof the messages.Medialiteracydoesnotreducemarketingmessageimpact.Proposal:Riskreductionmeanspromotingonlytothosepersonswhohavereachedanagewhentheyarelegallyconsideredtobecompetentenoughtoprotecttheirownwelfare.29World Health Organization,2004Seehttp://www.who.int/entity/dietphysicalactivity/strategy/eb11344/strategy_english_web.pdf30UKOfficeofCommunications(Ofcom)2007.Seehttp://stakeholders.ofcom.org.uk/consultations/foodads_new/statement/ and seehttp://collections.europarchive.org/tna/20100927130941/http://food.gov.uk/healthiereating/advertisingtochildren/nutlab/nutprofmod31Seehttp://www.slv.se/en‐gb/Group1/Food and Nutrition/Keyhole‐symbol/32FederalTradesCommission(2011)InteragencyWorkingGroupSeeksInputonProposedVoluntaryPrinciplesforMarketingFoodtoChildren.Seehttp://www.ftc.gov/opa/2011/04/foodmarket.shtm19Permittedtargetagegroupsshouldbesignificantlyolderthanthisinor...
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Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... cells, keratinocytes, and epithelialcells. When released into the extracellular milieu, theyexert their antimicrobial activity directly by attacking the microbe membrane, and in the intracellular ... species, and within a species it is regulatedby the cellular lineage, the differentiation ⁄ activationstate of the cell, and the tissue type [16]. Some antimi-crobial peptides are synthesized in the ... nonepithelial cells, in the heart, liver, and placenta [4], and hBD4 mRNA hasbeen detected in the testis, epididymis, lung tumor tis-sue [25], and gastric epithelial cells [26]. hBD1 and hBD2...
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