Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP pro

Tài liệu Báo cáo khoa học: Mouse recombinant protein C variants with enhanced membrane afﬁnity and hyper-anticoagulant activity in mouse plasma pptx

... prothrombin already obtains over 70% of its potential binding and protein C mutants II and III each have approximately 50%, whereas wild-type protein C has obtained a mere 19% of its potential binding. ... membrane-binding domain [9,10]. This Ca 2+ binding requires the presence of Gla residues. The Gla domains within the protein C family comprise 44 amino acids and contain...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khóa học: A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA Potential role in mRNA stabilization pptx

... role in general insulin mRNA stability, as PTB has recently been implicated in insulin mRNA stabilization in normoxic conditions [62]. Interestingly, we observed that the insulin mRNA PTB binding ... tract binding (PTB) RNA binding proteins. Analysis of the CSD/PTB binding sites revealed a potential role in VEGF mRNA stability, in both noninduced and induced conditions...

Ngày tải lên : 19/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... conditions of ATP binding and hydrolysis. Here, we summarize the properties of the three protein classes, with the main focus being on RNA chaperones and annealer proteins. Speciﬁcally binding proteins A ... starting points for invasion. The concerted process of opening of the initial double strand and the annealing of the new duplex ﬁnally results in either the replacem...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx

... protein kinase; MAPKK, mitogen-activated protein kinase kinase; MBP, myelin basic protein; OXI1, oxidative signal-inducible 1; PDK1, 3-phosphoinositide-dependent kinase 1; PTI1, Pto-interacting ... mitogen-activated protein kinases (MAP- Ks), MPK3 and MPK6, in response to oxidative stress. In addition, the serine ⁄ threonine protein kinase Pto-interacting 1-2 (PTI1-2) has bee...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc

... the control of the circadian clock. The phosphorylation and degradation of Per proteins have been suggested to control timing of the mammalian clock [8]. Moreover, BMAL1 and Cry proteins are subject ... transcription, resulting in reduced CLOCK ⁄ BMAL1 levels and decreased CCG expression [7]. This mode of repression leads to the cycling of BMAL1 mRNA levels in an anti-...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: intersubunit interactions during virus assembly doc

... of the precise residues and interactions involved in the NTD–CTD interface [46]. Most of these involve side chains from helix 8 of the CTD which pack against the N-terminal end of helix 4 of the ... capsid protein (CA) of HIV-1 is composed of two domains, the N-terminal domain (NTD) and the C-terminal domain (CTD). During the assembly of the immature HIV-1 particle...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeﬁciency virus: designing inhibitors of capsid assembly ppt

... Trp184 and Met185; HSQC, heteronuclear single quantum coherence; MA, matrix protein of HIV-1; NC, nucleocapsid protein; NTD, N-terminal domain of CA, comprising residues 1–145 of the intact protein; ... able to interact with CA and ⁄ or its domains, hampering HIV-1 assembly and infection. Abbreviations CA, capsid protein of HIV-1 (p24); CAC1, a CTD-binding designed peptide...

Ngày tải lên : 18/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

... 91–118. 19 Hibi M, Lin A, Smeal T, Minden A & Karin M (1993) Identiﬁcation of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev ... cell line PC-9. To investigate the signaling route by which AG1478 induced apoptosis, we examined the activation of c-Jun N-terminal kinase (JNK) and mitogen-activated protein kina...

Ngày tải lên : 18/02/2014, 13:20

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Tài liệu Báo cáo khoa học: Bone morphogenetic protein signaling in stem cells ) one signal, many consequences pptx

... neuroepithelial cells into astrocytes, by binding and hyper activating the promoter of glial ﬁbrillary acidic protein (GFAP). In parallel, BMP signals lead to enhanced expression of ID proteins, which in turn bind ... is initiated, resulting in the blockage of any kind of differentiation (Fig. 1). Taking these data from the culture system, it is inter- esting to look at stud...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx

... gag and gag-pol precursor polyproteins into structural and f unctional proteins. The HIV protease has been shown to be essential in the production of mature and infectious virions [4,5], hence inhibition ... pharmacokinetics in rats, which led us to investigate the effect of ﬂuoro-substituted inhibitors on cell absorption. The substitution of ﬂuorine for hydrogen introduce...

Ngày tải lên : 19/02/2014, 16:20

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Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc