Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt

... MINIREVIEW Marine toxins and the cytoskeleton: a new view of palytoxin toxicity M. Carmen Louzao, Isabel R. Ares and Eva CagideDepartamento de Farmacologia, Facultad de Veterinaria, Universidad ... Mediterranean Sea. Two of the most remarkable properties of paly-toxin are the large and complex structure (with different analogs, such asostreocin-D or ovatoxin -a) and the extreme acute animal toxicity. ... to maintain the shape and organization of the cell and the scaffolding for the actions of catalyticmolecules such as motor proteins. Nowadays, the actincytoskeleton is widely recognized as an...

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin pptx

... MINIREVIEW Marine toxins and the cytoskeleton: pectenotoxins,unusual macrolides that disrupt actinBegon˜ a Espin˜ a 1 and Juan A. Rubiolo1,21 Departamento de Farmacologia, Facultad de Veterinaria, ... studying new chemotherapy agents and actin cytoskeleton dynamics with potentialclinical applications.AbbreviationsF-actin, ﬁlamentous actin; G-actin, globular actin; OA, okadaic acid; PTX, ... morphological changes, reduction of mitochondrialmembrane potential, increases in cytoplasmic cyto-chrome c and Smac ⁄ DIABLO, and caspase-3 and caspase-9 activation. The inhibition of PTX-inducedcell...

Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins pptx

... MINIREVIEW Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxinsCarmen Vale and Luis M. BotanaDepartamento de Farmacologı´ a, Facultad de Veterinaria, USC, Lugo, SpainIntroduction The ... proteins, such as tau. One of the hallmarks of AD and tauopathies is the appearance of highly phos-phorylated tau isoforms in paired helical ﬁlaments.This might lead to dissociation of tau and microtu-bules, ... com-pound, named okadaic acid (OA), was found to beone of the toxic components of DSP [1]. OA was ﬁrstisolated from the marine sponges Halichondria okadaii and Halichondria melanodocia, and it was subsequentlyshown...

Tài liệu Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells pptx

... ON357, 5¢-TGAAACATCACCAACTAAATCTCCAA-3¢; ON358, 5¢-GACGACTCCATTGTTATAGGAAAAGAGT-3¢; ON359, 5 ¢-GCCGCTGGAGAAACAGCAT-3¢; ON360, 5¢-GCCACCCATTCGTCACAATC-3¢; and ON361, 5¢-ATGCAGAAGGGGATCCGG-3¢.Direct ... in the supernatants were quanti-fied by the BC assay quantification kit (Uptima) using BSAas the standard. Equal amounts of protein were preparedfor separation by SDS ⁄ PAGE.ImmunoprecipitationHEK293 ... overexpression of Epac and mimicked by a cAMPanalogue stimulating both PKA and Epac, but not byan Epac-specific cAMP analogue [25]. The differences inH89 sensitivity and possible signalling pathwaysinvolved...

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... 173,2083–2090.12 Otake H, Masuyama H, Mashima Y, Shinomiya A, Myosho T, Nagahama Y, Matsuda M, Hamaguchi S &Sakaizumi M (2009) Heritable artiﬁcial sex chromo-somes in the medaka, Oryzias latipes. ... 297–306.21 Kobayashi T, Matsuda M, Kajiura-Kobayashi H,Suzuki A, Saito N, Nakamoto M, Shibata N &Nagahama Y (2004) Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development ... Suzuki A, Kobayashi T, Paul-Prasanth B, Lau EL, HamaguchiS, Sakaizumi M & Nagahama Y (2007) DMY geneinduces male development in genetically female (XX)medaka ﬁsh. Proc Natl Acad Sci USA 104,...

Tài liệu Báo cáo khoa học: cN-crystallin and the evolution of the bc-crystallin superfamily in vertebrates pdf

... use of animals complied with the ARVO Statementfor the Use of Animals in Ophthalmic and Vision Research and the Intramural Animal Care and Use program of the National Institutes of Health (NIH).G. ... clear that this family has under-gone considerable changes, particularly during mam-malian evolution. These changes illustrate the way inwhich gene families may expand, contract and adapt.They ... Wilmarth PA, Taube JR, Riviere MA, Duncan MK &David LL (2004) Proteomic and sequence analysis of chicken lens crystallins reveals alternate splicing and translational forms of beta B2 and...

Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx

... orrestaurant names, or the names of racehorses, and so on, and on. The 1996 movie The Usual Suspectstakes its name from a memorable scene in 1942’sCasablanca, as does the Woody Allen play and movie ... instances of the patterns“as ADJ and * as” and “as * and ADJ as” fromGoogle, noting the combinations that are found and their frequencies. These frequencies provide linkweights for the Hofstadter-style ... withsalient properties Adj A 1 and Adj A 2 respec-tively, such that Adj A 1 and Adj A 2 are mutu-ally reinforcing. The combination is indexedon Adj A 1+Adj A2 . Example: “as dark and sophisticated...

Tài liệu Báo cáo khoa học: "Identifying Agreement and Disagreement in Conversational Speech: Use of Bayesian Networks to Model Pragmatic Dependencies" docx

... backchannel-accept. We used the DA annota-tion that we also had available, and used the DA tagsequence of part A and B as a feature.7When we add the DA feature set, the accuracyreaches 91.34%, which ... limited set of paired DAs(e.g. offer-accept, question-answer, and apology-downplay) can be realized as adjacency pairs, thenknowing the DA category of the B part and of allpotential A parts should ... overlap?Durational features:duration of A if A and B do not overlap: time separating A and Bif they do overlap: duration of overlapseconds of overlap with any other speakerspeech rate in A Lexical features:number...

Tài liệu Báo cáo khoa học: "Universal Grammar and Lexis for Quick Ramp-Up of MT Systems" doc

... Data about each parameter includes the language, the name of the parameter, the list of entities to which this parameter applies (its domain) and the list of parameter values (its 2 We have ... knowledge about the source language is a set of statements about morphological, syntactic, and lexical properties (parameters) of a language, listed together with their values and realization ... have an associ- ated set of realization options in each language. For instance, the parameter of gender in Ukrainian is described as follows: language: Ukrainian parameter: gender domain:...

Tài liệu Báo cáo khoa học: "Keyword Extraction using Term-Domain Interdependence for Dictation of Radio News" ppt

... because of many noisy keywords. In our method, newspaper articles and units of radio news are classified into many domains. At each domain, a feature vector is calculated by an encyclopedia ... The domain which has the largest similarity between the unit of news and the feature vector of each domain is selected as domain of the unit. Finally, the system ex- tracts keywords in each ... which appeared at least 5 times in the newspaper articles of same domains and calculated 141 feature vectors. 5.3 Domain identification experiment The system selects suitable domain of each...

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