Tài liệu Báo cáo khoa học: S100–annexin complexes – biology of conditional association doc

... 376 5–3 775.N. Miwa et al. Biology of S100–annexin complexes FEBS Journal 275 (2008) 494 5–4 955 ª 2008 The Authors Journal compilation ª 2008 FEBS 4955REVIEW ARTICLE S100–annexin complexes – biology ... S100A10–annexin A2 complex (see above).Other S100–annexin complexes Although the number of reports is limited, other S10 0– annexin complexes have been reported: S100A4–annexinA2 [61], S100A6–annexin ... [66,70,71,74]S100A10 [3,2 2–4 6]S100A11 [47,51,52,5 7–5 9,63] [58] [62]S100A12 [89]S100B [82,83] Biology of S100–annexin complexes N. Miwa et al.4946 FEBS Journal 275 (2008) 494 5–4 955 ª 2008 The Authors...

Tài liệu Báo cáo khoa học: S100–annexin complexes – structural insights pptx

... 204 3– 2046. S100–annexin complexes – structural insights A. C. Rintala-Dempsey et al.4966 FEBS Journal 275 (2008) 495 6–4 966 ª 2008 The Authors Journal compilation ª 2008 FEBSREVIEW ARTICLE S100–annexin ... The large conformational change of helix III and the exposure of the hydrophobic resi-dues, ﬁrst shown for S100B [3 6–3 8], have become a S100–annexin complexes – structural insights A. C. Rintala-Dempsey ... halves of the protein. Anextended linker region (residues 10 6–1 18, shown in grey) joins theC-terminus of helix IV with the N-terminus of helix V.A. C. Rintala-Dempsey et al. S100–annexin complexes...

Tài liệu Báo cáo khoa học: "Online Large-Margin Training of Dependency Parsers" docx

... of parent node in dependency tree. c-word: word of childnode. p-pos: POS of parent node. c-pos: POS of child node. p-pos+1: POS to the right of parent in sentence.p-pos-1: POS to the left of ... parent of xj. T = {(xt, yt)}Tt=1denotes thetraining data.We follow the edge based factorization method of Eisner (1996) and deﬁne the score of a dependencytree as the sum of the score of ... Proceedings of the 43rd Annual Meeting of the ACL, pages 9 1–9 8,Ann Arbor, June 2005.c2005 Association for Computational LinguisticsOnline Large-Margin Training of Dependency ParsersRyan...

Tài liệu Báo cáo khoa học: "Counter-Training in Discovery of Semantic Patterns" doc

... duality between the space of documents and the space of patterns: good extrac-tion patterns select documents relevant to the chosenscenario; conversely, relevant documents typicallycontain ... primary aim of the learning is to train astrong recognizer for ; is embodied in the set of good patterns. However, as a result of training, the procedure also produces the set of doc- uments ... correlated with the documents thathave high relevance. Add to the growing set of seeds , and record its accuracy.4. Document Relevance: For each documentcovered by any of the accepted patterns...

Tài liệu Báo cáo khoa học: "Detecting Errors in Part-of-Speech Annotation" docx

... instance of this method based on identity of words in the variation contexts, so-called variationn-grams, successfully detects a variety of errors inthe WSJ corpus.The usefulness of the notion of ... table reports the level of variation in theWSJ across identical contexts of different sizes. Inthe next section we turn to the issue of detectingthose occurrences of a variation n-gram for ... good cut-off point for the WSJ.This becomes apparent when one takes a look atwhere the 59 ambiguous variation nuclei arise: 32 of them are variation nuclei of 6-grams, 10 are part of 7-grams,...

Tài liệu Báo cáo khoa học: "Resolution for Machine Translation of Telegraphic Messages" docx

... maximized when we rely on syntactic rules defined in terms of part -of- speech at the cost of a high degree of ambiguity. Thus, the goal of maximizing the parsing coverage while minimizing the ... results of the technique on the basis of two sets of unseen test data. In section 5 we discuss system engineering issues to accommodate the proposed technique, i.e., integration of part -of- speech ... the adaptation of the understanding system. Finally section 6 provides a summary of the paper. 2 Translation of Telegraphic Messages Telegraphic messages contain many instances of phrases with...

Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... internalizedPCSK9–LDLR complexes. Effect of association time on the dissociation of [125I]TC-PCSK9The dependence of dissociation of [125I]TC-PCSK9and [125I]TC-PCSK9-D374Y on the length of associa-tion ... determined bythe rate of association. It should be noted that quanti-tative analysis of the more rapid phase of association requires measurement of the binding on time scales of minutes, a time ... structure of PCSK9: a regulator of plasma LDL-cholesterol. Structure 15, 54 5–5 52.36 Anderson RG, Brown MS & Goldstein JL (1977) Role of the coated endocytic vesicle in the uptake of recep-tor-bound...

Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efﬁciency doc

... – – 0.444 ± 0.008 – – PhyP 5 PhyH-DI 120 0.523 ± 0.014 0.448 1.17APPA 5 – – 1.978 ± 0.022 – – APPA 5 PhyH-DI 120 2.310 ± 0.004 1.982 1.20PhyH 120 – – 3.260 ± 0.170 – – PhyH-DI ⁄ DII 120 – – ... yieldExpectedyieldPhyH-DI 120 – – 0.004 ± 0.003 – – PhyH-DII 120 – – 0.302 ± 0.013 – – PhyH-DII 120 PhyH-DI 120 0.500 ± 0.026 0.313 1.63168PhyA 5 – – 0.536 ± 0.007 – – 168PhyA 5 PhyH-DI 120 1.345 ... ⁄ DII 120 – – 0.569 ± 0.015 – – 2 · PhyH-DII 120 – – 0.599 ± 0.017 – – Catalysis of a dual-domain b-propeller phytase Z. Li et al.3036 FEBS Journal 278 (2011) 303 2–3 040 ª 2011 The Authors Journal...

Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... because theoff-rates are high (koff‡ 0.2 s)1) [25]. A further way of describing macromolecular complexes is by themolecular interface of the interacting molecules. Incommon stable complexes ... contrast,interfaces of transient complexes are often not denselypacked, and water can more easily gain access to theRNA–protein interface to increase the dissociationprocess. The promiscuity often reported ... with manybasic amino acids [48,50,5 2–5 6]. Both this feature andthe often reported dependence of the activity on theionic strength of the solution [50,5 7–5 9] hint at theinteraction between...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... with a sulfone [R–S(O2)–R¢] [20], sulfonate ester[R–S(O2)–O–R¢] [21,22], sulfonamide [R–S(O2)–NH–R¢] [23], sulfamate [R–O–S(O2)–NH–R¢] [24], sulfamide[R–NH–S(O2)–NH–R¢] [25,26], and ... which phosphoryl [R–O–P(O2))–O–R¢] groups are replacedwith N-acylsulfonamidyl [R–C(O)–N)–S(O2)–R¢] or sulfonimidyl [R–S(O2 )– N)–S(O2)–R¢] groups increase the number of nonbridging oxygens ... University of Bath, UK2 Department of Biochemistry, University of Wisconsin–Madison, USA3 Department of Chemistry, University of Wisconsin–Madison, USAIntroductionUpon catalyzing the cleavage of...

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