Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... MINIREVIEW SREBPs: physiology and pathophysiology of the SREBP family Hitoshi ShimanoDepartment of Internal Medicine (Endocrinoglogy and Metabolism), Graduate School of Comprehensive Human ... a direct target of SREBP [20]. The role of SREBP- 1a in the regulation of cell growth and the cell cycle might be biphasic and complex, and needs to be further investigated. SREBP is evolutionarily ... adipogenesis [44]. The roles of SREBP- 1c in adipogenesis are currently controversial. Physiology and pathophysiology of the SREBP family H. Shimano618 FEBS Journal 276 (2009) 616–621 ª 2008 The Author...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... expression of T-bet has beenseen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... end of the gene, where the zebrafish and human sequences appearto be quite diverse. Together with the well-conservedgene organization, there is a conservation of syntenybetween the human and ... CD4+CD25+Foxp3+Tregor whetherthey induce the production of these cytokines fromanother population of cells [20].To date, our knowledge about the different types of Th and Tregresponses relates...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... analysis of the topological modules of the Fig. 3(labelled A–G) shows that they include structural and ⁄or functional features. Table 3 summarizes the main structural and functional features of thesegroups. ... [50]. Group F contains90% of the members of the nuclear receptor hormonesuperfamily of the HTFN (they also are Zn finger pro-teins) [26]. In these groups, functionality and structuralhomogeneity ... functions, and topologi-cal features retain functionality and phylogeny. How-ever, the nature of the connections between thesefactors needs to be understood at the level of the pro-tein domain. The...
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Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... that the data weredescribed best by a two-binding site model. The IC50 (the concentration of the competing ligand that inhib-its 50% of the specific binding of [125I]TC-PCSK9) val-ues for the ... higher-affinity and lower-affinity binding sites are listed in Table 1. The high-affinity and the low-affinity sites accountedfor 25% and 75% of the total binding, respectively.These estimates of the relative ... PCSK9-S127R, only the upper and lower, respectively, halves of the ranges are shown, to avoidoverlap of the error bars. The results are expressed as percentage of control (c.p.m. in the absence of unlabeled...
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx
... performed and the P-values are displayed, as calculated using the Student’s t-test. The mean and standard deviations of absolute numbers of the observedcolonies are indicated. (C) Number of colonies ... [19]. The Rho family of small G proteins represents alarge group of the Ras superfamily of GTPases. Morethan 20 proteins of this class have been described todate, among which RhoA, Rac1 and ... were lysed and dilutions plated and cultured for 2 days at27 °C. The number of colonies for OTUB1 and the OTUB1 mutants were counted and presented relative to the number obtained for the control...
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt
... Y5 and y6) thatvary in their binding profiles and in their distributionin the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of ... stromal cells and osteoblasts [40,46–48],despite the absence of the other Y receptors (Y2, Y4,Y5 and y6) [40,46]. In addition to the presence of NPY-immunoreactive fibers and the presence of NPY receptors, ... effect and the decreased leptinlevels are absent in female mice, suggesting a genderspecificity of the bone response.Further assessment of the role of NPYin the control of bone homeostasis –the...
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Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx
... number of these modifications is low, the density of modifications is much the same as in the rest of the lin-ker histones. It is the shortness of the N-terminal tailsTable 1. Alignment of chicken, ... studies [14–16] suggest that the linkerhistone is close to the dyad axis of the core particle at the entry and exit of the DNA. Similarly, the geometry of one nucleosome in the fibre relative to a ... histonesHistorically, the location of the globular domain of the linker histone has been a matter of contention [13].Currently, although there is a good degree of agree-ment about the overall parameters of the...
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Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf
... organelle and membrane proteins are synthe-sized and folded with the assistance of molecular chap-erones and other folding factors in the endoplasmicreticulum (ER). In many cases, the process of ... GmPDIL-3a and GmPDIL-3b were detected at a density of 1.21 gÆmL)1in the presence of MgCl2. In the presence of EDTA,which releases ribosomes from the rough ER [24], the peaks of GmPDIL-3a and GmPDIL-3b ... isomerase (PDI) and other PDI family proteins are mem-bers of the thioredoxin superfamily and are thought to play important rolesin disulfide bond formation and isomerization in the endoplasmic...
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Tài liệu Báo cáo khoa học: Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni pdf
... localizationsignal and a DNA-binding domain in the MH1 domain and the L3 loop, and the C-terminal, receptor phos-phorylation motif in the MH2 domain (Fig. 1A). The amino acid composition in the L3 loop of R-Smadsprovides ... of cellular media-tors called receptor-regulated Smads (R-Smads). The R-Smads of the TGF b–activin pathway include Smad2 and Smad3. The R-Smads of the BMP pathwayinclude Smads 1, 5 and 8. The ... reporter); the duration of the development of blue color in the LacZ filter-lift assay (activation of LacZ reporter); and the b-gal units calculated from the liquid LacZ assay (activation of LacZ...
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf
... determination The reaction mixtures were as in the standard assay, exceptthat the components specified in the Results were added, and the concentrations of the substrate and enzyme varied asrequired for the ... independently evaluate the effects of ionicstrength and Mg2+on the activity and specificity of OGG1, we measured the apparent values of k2 and k3under conditions of low salt (KPionly) and no Mg2+,low ... [19,20]. The results of the fluorescence titration experiments aresummarized in Fig. 2. In the absence of MgCl2, the affinity of Fpg for the THF:C ligand was 1.6-fold higherthan for the THF:A ligand....
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