... minimal.Morphological evidence of the antiapoptoticeffect of HSSAs shown in Fig. 2A,B, the treatment of cells with 50 lm CCCP induced profound changes in the nuclearmorphology of hepatoma cells, with chromatin ... Bloom SE(2003) Reversal of Bcl-2-mediated resistance of theEW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of theHSS and mitochondrial permeability ... injury, and HSS protection is identical to that observed with cyclosporin A, an inhibi-tor of MPT. Therefore, we propose that the protective effect of HSS maybe associated with blockade of MPT.AbbreviationsALR,...