... PREDMUT
(PREDict MUTants) , was developed for prediction of the
severity of p53 mutants. The method was trained on a set
of known mutants and subsequently evaluated on another
set.
The method is based on parameters ... À
yðÞ
2
q
where x and y are values from the two parameters mea-
sured, and
x and y are the mean values for the respective
parameters....
... summarizes recent progress in the understanding of how
osmosensing and osmosignaling integrate into the overall context of growth
factor signaling and the execution of apoptotic programs.
Abbreviations
EGF, ... of the
CD95 from inside the hepatocyte to the plasma mem-
brane [39], which depends on a ROS-mediated tyrosine
phosphorylation of the epidermal growth fac...
... proceed with further biological testing of
these compounds and the investigation of whether this
pathway operates in the human body in vivo.
Experimental procedures
Preparation of enzymes
Cytochrome ... the adre-
nal gland may receive vitamin D from the bloodstream
for further metabolism [4].
In conclusion, the identification of new metabolites
of vitamin D3 made by...
... Professor Hayao Taguchi (Tokyo
University of Science) for the gift of the plasmid carry-
ing the LDH gene from T. caldophilus; Dr Miho
Aoshima and Ms Ayako Nishiyama for the preparation
of the ... complete
the cycle [6,7]. POR is one of the key enzymes of the
reductive TCA cycle, and catalyzes the anabolic reduc-
tive carboxylation of acetyl-CoA. Two [4Fe-4...
... the numbering of the amino-
acid sequences of immunoglobulins and the definition of
their CDR loops, as described from 1997 [13]. The number-
ing and definition of the L-CDR3 and H-CDR3 loops of
mAb4E11 ... segment, and the V
H
-D, D-J
H
, and
V
L
-J
L
junctions [17]. They are located at the center
of the antibody combining site [18,19] and provide
the...
... How-
ever, the matching of the part -of- speech tags of the
sentence sequences to the left and right of the in-
fix, against the part -of- speech tags of the seed fact,
only succeeds for the last three ... outer
boundaries of the fact are computed separately for
the beginning of the first (left) and end of the sec-
ond (right) phrases of the candida...
... character-
ization of the thermally induced aggregation of SK using a
variety of techniques. The results provide us with some of
the properties of these high molecular mass aggregates and
help to delimit the ... number of two-state transitions. In
these fittings the heat capacity change, DC
p
,forthe
unfolding of each domain was fixed by using the values
obtained...
... preconditions of this action depend strictly on the
mutual belief of the speaker and the hearer at the time of
the
utterance. The noun
phrase in a
sentence such
aa
(6) Use
the same wrench ...
action, the speaker and hearer mutually know of a plan that
will result in identification of the intended referent, and in
the case of the S[ action, the...
... inflammation [17], and
immune response [11,12]. The study of these events is
taxing, as the biosynthesis of glycoproteins is not tem-
plate driven. This results in the formation of so-called
‘glycoforms’ ... University of Oxford, UK
Introduction
Post-translational modifications (PTMs) of proteins
modulate protein activity and greatly expand the diver-
sity and complexity...
... handedness, and two
of the rings face in the opposite direction in the
membrane to the other two, forming the same pattern
as in the AFM surface representation of Fig. 2A. By
comparison with the ... By
comparison with the 3D structure of the I. tartaricus
c ring [24], the black rings represent the view from
the cytoplasm (open rings in AFM) and the red on...