Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... participates in picolinic
acid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzyme
stands at a branch point of the tryptophan to NAD pathway, and deter-
mines the final fate of the amino acid, ... The crystal structure of human
a
-amino-
b
-carboxymuconate-
e
-semialdehyde decarboxylase in complex with
1,3-dihydroxyacetonephosphate...
... pUSI2E (a
G
). DNA
segments encoding the b and c subunits of glycerol
dehydratase were amplified by PCR using pairs of primers
5¢-CATATGCAACAGACAACCCAAATTCAGCCC-3¢
and 5¢-AGATCTTATCACTCCCTTACTAAGTCGATG-3¢
for ... northern and southern least-squares planes is 5.5°,
indicating that the corrin ring of the glycerol dehydratase-
bound cobalamin is also almost planar, as compared...
... The Gag subunits are radially extended, with
the N-terminal domain, MA, associated with the inner
layer of the viral membrane, and the remaining
domains forming the innermost protein layers accor-
ding ... spectroscopy.
The N-terminal domain of CA (NTD) and the C-ter-
minal domain of CA (CTD) are small, globular and
mainly helical. NTD contains a- helices 1–7...
... that of wild-type, and those of the
assembly-competent mutants E18 7A and N18 3A: the
conformations of the two assembly-incompetent
mutants (Y16 9A and L21 1A) in the absence of CAI
are the same as the ... the
protein. This movement creates a large cavity where the
aromatic ring of CAP-1 inserts; the urea and dimethyla-
monium groups of CAP-1 also m...
... 1465–1470.
53. Aoki, M., Ogasawara, M., Matsubara, Y., Narisawa, K.,
Nakamura,S.,Itoyama,Y.&Abe,K.(1994)Familialamyo-
trophic lateral sclerosis (ALS) in Japan associated with H46R
mutation in Cu/Zn ... black and the residue
labels are underlined.
Fig. 3. Tube representation of the family of 30 structures of human reduced native SOD obtained with
DYANA
calculations a...
... Ciclosporin A inhibits PPWD1 activity against suc-AAPF-pNA. (C) Binding and
catalysis of isomerization for the standard substrate suc-AAPF-pNA. Black and red spectra of the Ala residues in the peptide ... response
events, including the participation of host CypA in
binding the capsid protein Gag of HIV-1 during infec-
tion in humans and packaging into HIV virio...
... an
activating element binding E2F1, -2 and -3. These acti-
vating E2Fs cooperate with NF-Y proteins binding to
CCAAT-boxes and with Myb proteins associating with
a distal Myb site in activating the ... homologs of Caenor-
habditis elegans synMuvB proteins and is composed of
p130, E2F4 ⁄ 5 and DP1 ⁄ 2 and a module containing the
MuvB proteins Lin-37, Lin-52, Lin-5...
... cells,
refolded and purified [31]. The ECD was biotinylated
and immobilized on streptavidin-coated BIAcore chips.
Ligand binding was first analysed using the mature
growth factor. The fast association rate and ... induction of alkaline phos-
phatase in C2C12 cells. AP activity was measured by determination of the change in extinction (DE) per minute and microgram protein...
... CBP21 and CHB1.
Degradation of a- and b-chitin
The degradation rates of a- and b-chitin were assayed
with LlChi1 8A in the presence or absence of
LlCBP3 3A. As both chitin variants, and especially
a- chitin, ... chains);
b-chitin (parallel packing of the chitin chains); and the
minor polymorph c-chitin (mixture of parallel and
antiparallel chain packing)...
... ligands, apart from
the identical PDZ binding motif (ATEV) found at the
C-terminus of Delta-1 and Delta-4. The cytoplasmic
tail of Jagged-1 (Fig. 1) contains a different C-terminal
PDZ interacting ... A role of the
cytoplasmic tail of membrane-spanning proteins in
protein–protein interactions has also been proved, e.g.
the case of the association between the...