Tài liệu Báo cáo khoa học: Disulﬁde bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt

... occurring disulfide bridge on liver BABP ligand-binding properties and backbone dynamics have been investigatedby NMR. Interestingly, the disulfide bridge does not modify the protein-binding stoichiometry, ... glycochenodeoxycholic acid; I-BABP, human ileal bile acid-binding protein; iLBP, intracellular lipid-binding protein; L-BABP, chicken liver bile acid-binding protein.FEBS Journal 276 (2009) 6011–6023 ... leadto distinct binding and functional properties [22,23]. In line with this, we have shown here that the presence ofa disulfide bridge, while maintaining the same bindingstoichiometry, induces...

Tài liệu Báo cáo khoa học: Identiﬁcation of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis docx

... Arg522 (NH1)coordinates the chloride ion in tACE]. Arg514 in ACE2 is displaced relative to Arg522 in ACE and issomewhat closer to the zinc-binding site. The CL2binding site is in close proximity ... contains the zinc-bind-ing site, which faces into the deep cleft formed by thetwo subdomains connected at the base of the cleft.The hinge-bending motion observed upon inhibitorbinding occurs ... The zinc protease domain is divided into two sub-domains, which are deﬁned by the movement of thesubdomains relative to each other upon inhibitor bind-ing. Subdomain I (N-terminal) contains...

Tài liệu Báo cáo khoa học: "Phrase-Based Translation Model for Question Retrieval in Community Question Answer Archives" ppt

... 2010.Learning phrase-based spelling error models fromclickthrough data. In Proceedings of ACL.K. Wang and Z. Ming and T-S. Chua. 2009. A syntactictree matching approach to ﬁnding similar questions in community-based ... theseexisting approaches are considered to be context in- dependent in that they do not take into account anycontextual information in modeling word translationprobabilities. For example in Table ... language modelingapproach to information retrieval. In Proceedings ofSIGIR.W. H. Press and S. A. Teukolsky and W. T. Vetterlingand B. P. Flannery. 1992. Numerical Recipes In C.Cambridge Univ....

Tài liệu Báo cáo khoa học: RMI1 deﬁciency in mice protects from diet and genetic-induced obesity pptx

... observable.Interestingly, the RMI1 mRNA level increased signiﬁ-cantly in the liver and intra-abdominal fat of the obesephenotype mice; however, that in the skeletal muscledid not increase, and that in ... theBloom’s syndrome gene helicase complex that maintains genome integrityand activates cell-cycle checkpoint machinery. Interestingly, diet-inducedexpression of E2F8 mRNA, which is an important ... high-fatdiet contains 32% safﬂower oil, 33.1% casein, 17.6%sucrose, 1.4% vitamin mixture, 9.8% mineral mixture, 5.6%cellulose powder and 0.5% dl-methionine. Casein, sucroseand the vitamin and mineral...

Tài liệu Báo cáo khoa học: Vấn đề thưởng thức văn học nghệ thuật của công chúng hiện nay docx

... bd phan cdng chiing va ngay ehinh bd phan cdng chiing ay cung khdng d'n dinh. Dii sao di niia thi edng ehiing ciing dang quyet dinh hay gdp phan quyet dinh sir thanh edng ... tam chia edng ehiing thanh hai loai edng chiing nghe thuat: edng chiing tinh hoa va cdng chiing phd' thdng. Cdng chiing tinh hoa la nhiing ngudi am hie'u nghe thuat, hp dugc ... dpng van nghe eiia minh, hp eiing phii nghien eiiu cdng chiing nhu viee nghien ciiu thi trubng cua nganh khoa hpc marketing trong kinh te. Vai trb ciia cdng chiing dan ed vai...

Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc

... Schiffmann SN (2002) ‘New’functions for ‘old’ proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parval-bumin, in cerebellar physiology. Studies with knockoutmice. ... implicated Ca2+signalingthrough calcineurin (CaN) [13] and calmodulin kinase[14] to play an important role. In addition, a recentstudy indicates an involvement of Ca2+signaling in thecontrol ... 2005)doi:10.1111/j.1742-4658.2005.05046.xParvalbumin (PV), a small cytosolic protein belonging to the family ofEF-hand calcium-binding proteins, is highly expressed in mammalianfast-twitch muscle ﬁbers. By acting as a ‘slow-onset’...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... K,Kuroiwa Y et al. (2008) RNA-binding protein TLS is amajor nuclear aggregate-interacting protein in hunting-tin exon 1 with expanded polyglutamine-expressingcells. J Biol Chem 283, 6489–6500.25 ... solid line), in the presence of100 lM neurotoxin (•, dotted line), in thepresence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and50 lM dopamine (h, dashed line).Modulation ... absence of Lewy bodies in MPTP-induced parkinsonism in humans. However,eosinophilic intraneuronal inclusions have been seen in the same region as Lewy bodies in squirrel monkeysinjected with MPTP...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... uracil moiety binding in the same fashion [38], which could trigger the initialbinding of both substrates. In UpG, the binding of theguanine moiety is deterred by exocyclic O6. Closeinspection ... S2). In bothstructures, the bound inhibitors span the nucleo-base-binding subsites. Surprisingly, however, theN-acylsulfonamidyl groups point away from the active site (Figs 4 and 5). In N-acylsulfonamide ... enzymes. 8. Inhibitor binding toribonucleases. J Mol Biol 45, 491–511.33 Ui N (1971) Isoelectric points and conformation of proteins. I. Effect of urea on the behavior of some proteins in isoelectric...

Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

... having sufﬁcient power are thereforeextremely important in minimizing the in uence ofconfounding factors arising from inherent problemsassociated with breeding APP transgenic mice andmaintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages areautomated learning cages where animals carryingtransponders are housed in groups and trained in learning corners. Each individual ... thepathogenic interaction between Ab and a-synucleinwas investigated by crossing PDGF–a-synucleinand APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with...

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... fundamentalSET domain in these HMTs is intriguing. In addition,many of the H3K4 HMTs share several domains ⁄ com-ponents, indicating a common mechanism of action.Concluding remarksStudies in several ... proteins in budding and ﬁssion yeastsshare a high degree of similarity in their SET domains.However, these two proteins exhibit 26% sequence iden-tity overall [69]. The N-termini of Set1 in ... compac-tion of DNA in a higher order chromatin structuremakes it inaccessible for proteins involved in differentDNA-transacting processes such as transcription, repli-cation, recombination and DNA...

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