Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... vari-ants of amyloid fibrils differing in the number of fila-ments and the helicity of their intertwining [22–24]. The structure of the mature fibrils has been deter-mined in a limited number of cases ... different conformations belong. However, ourunderstanding of the importance of different parts of the molecule and their flexibility in the process of amy-loid fibril formation often results more ... intwo ways: either the small oligomer rings gather oneabove the other (meaning the protofibril would be hol-low) or they open and rearrange to become a growingfilament, a number of which wind...

Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

... Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction Abdulmaged M. Traish1, Robert J. Feeley1 and Andre Guay21 Department of Biochemistry and Urology, ... Endothelial dysfunction and androgen deficiency have previously been linked to the pathophysiological mechanisms of erectile dysfunction. The underlying pathophysiological mechanisms of endothelial dysfunction ... on the potential pathophysiologicallinks including obesity- related androgen deficiency and obesity- induced endothelial dysfunction. Obesity promotes inflammatoryresponses and contributes toendothelial...

Tài liệu Báo cáo khoa học: Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase docx

... n, Number of [A] tested; k2⁄ k1, the value of the intercept in the Scrutton and Utter plot, where k2 and k1are the rate constants of the inhibition of either the bilitranslocase-ligand complex ... kA and k0are the inactivation rate constantseither in the presence or in the absence of variousconcentrations of a ligand A, k2 and k1are the rate constants of the inhibition of the bilitranslocase–bilirubin ... vacuolar membrane and the plasma membrane could not be resolved, because the vacuole takes a large part of the lumen of the cell and the tonoplast is almost in contact with the plasmamembrane....

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... as the ATP-unbound and Ca2+-boundE1Ca2+form. In the histogram (Fig. 2A) of the dis-tribution of the height of the projection of the embed-ded molecule above the ﬂat membrane surface, the average ... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy-ses of SERCA were performed with the data obtained in the pres-ence of (A) ... presence of both ATP and Ca2+were excluded from the following analyses.Visual characteristics of the Albers–Post scheme The number of peaks (i.e. the number of up–downconformational changes of...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... triggering the production of proinﬂammatory cytokines and liverinjury [13].Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform activities and gene ... groupsFor depletion of KCs in vivo, 7.5 mgÆkg)1 of GdCl3wasinjected via the tail vein at 48 and 24 h before the perfor-mance of CLP or sham operation, based on the ﬁndings of other investigators ... aorta. The left and median lobes of the liverwere isolated immediately, and stored at )75 °C untilassayed.Isolation of hepatic microsomal fraction The excised liver was minced and then homogenized...

Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx

... described below. Figure 1B shows the patternseen after the development of the blot. With increasein time of incubation, the intensity of the band for the monomeric protein decreased, whereas the ... a-synucleinwas because of MPTP alone and not because of its con-version to MPP+, RP-HPLC of the samples was car-ried out. The incubated samples (a-synuclein alone and in the presence of 100 and 200 ... presence of 100 lM MPTP and 50 lM dopamine (F), in the presence of 200 lM MPTP and 50 lM dopamine (G), in the presence of 100 lM MPP+ and 50 lM dopamine (H) and in the presence of 200 lM MPP+and...

Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx

... is of asufﬁcient size (cut-off of $ 1.5 kDa) to allow the pas-sage of solutes and water, which may also result inrupture of the outer membrane. The identity of the proteins comprising the ... efﬂux rates, and correlating this with the difference of DWm (termedDelta phi) before and after the addition of ADP(2 mm) to WT and CYPD KO mitochondria, and cal-culated on the basis of steady-state ... translocase (ANT). The molecular turnover num-bers and the number of active ANT molecules may vary from those of F0F1-ATP synthase molecules permitochondrion [20,21]. Furthermore, the steady-stateADP–ATP...

Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... other members of this kinase family (includingPar1a, Par1c and Par1d), and that these interactionscontribute to the H. pylori-induced elongation pheno-type of AGS cells. Taken together, these ... HP0522 and HP0535 may be novel T4SS effectors [4]. WhetherHP0522 and HP0535 are indeed translocated by the T4SS is only one of the questions that need to be answered in future studies to uncover the ... colonizes the surface area of the gastric mucosa in the human stomach and is one of the most adapted microbial pathogens.  50% of the world’s population carries this bacterium, causingchronic, often...

Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf

... increasing levels of obesity, implying thatdiet may be associated with the development of insulinresistance, type 2 diabetes, cardiovascular disease and other pathologies in the general population ... 5B). The ER is the site of synthesis of all secretory pro-teins and resident proteins of the membrane system, and any perturbation that compromises the protein-folding capacity of the organelle ... coadministered (Fig. 4C).Taken together, these results indicate that the location of the protective action of oleate was upstream of ERstress activation.Whether the protection offered by oleate was speciﬁcfor...

Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 ﬁ 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf

... during the glucan syn-thesis can be interpreted with respect to the kineticproperties of enzymes. In other words, the relationship between the enzyme kinetic properties and the process of insoluble ... at the C-terminal end of GTFs act as mediators of the shift between the processive and nonprocessive processes;GTF-I may otherwise randomly migrate on the dextranwithout dissociating during the ... addition, the kinetics of the acceptor reactions appeared to be similar between GS and GSGB.Kinetic simulation of GTF glucan synthesisTo explain the time course of saccharide productionduring the...

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