... known inhibitor of < /b> PI3 kinase activ-ity. In addition, the < /b> inhibition of < /b> mTOR activity wasachieved in the < /b> presence of < /b> 5 ngÆmL)1rapamycin, asrevealed by < /b> the < /b> absence of < /b> the < /b> phosphorylated form of< /b> p70S6K. ... activation by < /b> AKT elicits the < /b> phos-phorylation of < /b> two known regulators of < /b> protein syn-thesis, P70S6K and the < /b> eukaryotic initiation factor< /b> 4E-binding protein PHAS-1 (PHAS/4EBP1) [13, 14]< /b> ,thereby ... selective inhibitor of < /b> ganglioside biosynthesis,P4 [26], and characterized for their proliferation andA B CEDFig. 3. Neu2 expression < /b> is strictly depend-ent on insulin-like growth factor < /b> 1 (IGF-1)signaling....