Tài liệu Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 refined models suggest environment-dependent induction of alternative bent ⁄extended resting states doc

Tài liệu Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 refined models suggest environment-dependent induction of alternative bent ⁄extended resting states doc

Tài liệu Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 refined models suggest environment-dependent induction of alternative bent ⁄extended resting states doc

... FEBS Solution properties of full-length integrin a IIb b 3 refined models suggest environment-dependent induction of alternative bent ⁄ extended resting states Camillo Rosano 1 and Mattia Rocco 2 1 Nanobiotecnologie, ... authors. Refined a IIb b 3 models C. Rosano and M. Rocco 3202 FEBS Journal 277 (2010) 3190–3202 ª 2010 The Authors Journal compilation ª 2010...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... mecha- nism of transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformers of the solu- tion ... be considered as an evolutionary intermediate that may share properties of both protein families, or at least have acquired some of the properties of the highly evolved cyto...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Electrical properties of plasma membrane modulate subcellular distribution of K-Ras ppt

Tài liệu Báo cáo khoa học: Electrical properties of plasma membrane modulate subcellular distribution of K-Ras ppt

... of cytoplasmic composition of anionic li- pids in membrane binding of K-Ras was evaluated by studying the effect of ATP depletion, which inhibits inward movement of PS, with consequent loss of plasma ... subcellular distribution of K-Ras after dis- ruption of the electrical properties of the outer and inner leaflets of plasma membrane and ionic gradients through it. Remov...
Ngày tải lên : 19/02/2014, 00:20
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Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc

Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc

... Design and synthesis of a potent cyclic analogue of the myelin basic protein epitope MBP72-85: importance of the Ala81 carboxyl group and of a cyclic conformation for induction of experi- mental ... a-helicity in a stabilizing solution environment, and supports the use of DPC-d 38 or TFE-d 2 [30] as a structure-stabilizing condition for solution NMR studies of the full-le...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

... results suggest that dimerization of cystatin F is linked to disulfide bond formation, which is responsible for the loss of inhibitory activity of the pro- tein. We also noticed that monomerization of ... localization of cystatin F, its restricted and readily regulated expres- sion [18], selective and not too potent inhibition of cathepsins are all in favor of the active role...
Ngày tải lên : 19/02/2014, 17:20
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Tài liệu Báo cáo khoa học: Enzymatic properties of wild-type and active site mutants of chitinase A from Vibrio carchariae, as revealed by HPLC-MS pptx

Tài liệu Báo cáo khoa học: Enzymatic properties of wild-type and active site mutants of chitinase A from Vibrio carchariae, as revealed by HPLC-MS pptx

... thank Prof. Steve C. Fry, Institute of Cell and Molecular Biology, Univer- sity of Edinburgh, Edinburgh, UK, and Dr Albert Schulte, Ruhr University of Bochum, Germany, for critical reading of the ... quantities of protein util- izing the principle of protein-dye binding. Anal Biochem 72, 248–254. 33 Laemmli UK (1970) Cleavage of structural proteins dur- ing the assembly of the...
Ngày tải lên : 20/02/2014, 01:20
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Tài liệu Báo cáo khoa học: Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom docx

Tài liệu Báo cáo khoa học: Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom docx

... connects the a-helix to strand b 2 of AaHII. This can be Fig. 5. Solution structure of crotamine. Stereo view of the 26 NMR models superimposed over the backbone atoms of residues 2–39. 1974 G. Nicastro ... residue, located at the end of strand b 1 of Crt, presents its counterpart in Trp38 similarly located at the end of strand b 2 of AaHII. Interestingly, chemical modifica...
Ngày tải lên : 20/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner pptx

Tài liệu Báo cáo khoa học: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner pptx

... one of a few major Myb-interacting proteins. The moderate basal level of sumoylation was greatly enhanced by cotransfection of PIASy, an E3 ligase for SUMO-1. The functional consequence of abolishing ... formed with low efficiency. This suggests that K527-conjugation enhances the efficiency of sumoylation at the other site. A third line of independent evidence for sumoylation of c...
Ngày tải lên : 21/02/2014, 00:20
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt

... contacting the DNA backbone. The solution structure of the MBD of MBD1 shows high similarity to that of MeCP2 except for the C-terminus [18]. At the C-terminus of the MBD, MeCP2 exhibits a one-turn ... complexes were analyzed by comparison of 1 H- 15 N HSQC spectra of free MAR-BD with those of MAR-BD titrated with the 15- mer oligonucleotide duplex at molar ratios of 1 : 1.2...
Ngày tải lên : 21/02/2014, 00:20
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Tài liệu Báo cáo khoa học: Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc

Tài liệu Báo cáo khoa học: Solution NMR structure of five representative glycosylated polyene macrolide antibiotics with a sterol-dependent antifungal activity doc

... One cycle of random SA consisted of 1500 steps of 3 fs at 1000 K followed by 3000 cooling steps of 1 fs from 1000 K to 100 K. At the end, each structure was subjected to 1500 steps of conjugate ... analysis of the model ensemble indicates, a possible hydrogen bond between the hydrogen of OH9 (H O 9) and the oxygen of OH7 (O H 7) which can contribute to the stabilization of t...
Ngày tải lên : 21/02/2014, 03:20
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